Salvianolic acid B inhibits low‐density lipoprotein oxidation and neointimal hyperplasia in endothelium‐denuded hypercholesterolaemic rabbits

BACKGROUND: Atherosclerosis and restenosis are inflammatory responses involving free radicals and lipid peroxidation and may be prevented/cured by antioxidant‐mediated lipid peroxidation inhibition. Salvianolic acid (Sal B), a water‐soluble antioxidant obtained from a Chinese medicinal herb, is believed to have multiple preventive and therapeutic effects against human vascular diseases. In this study the in vitro and in vivo inhibitory effects of Sal B on oxidative stress were determined. RESULTS: In human aortic endothelial cells (HAECs), Sal B reduced oxidative stress, inhibited low‐density lipoprotein (LDL) oxidation and reduced oxidised LDL‐induced cytotoxicity. Sal B inhibited Cu²⁺‐induced LDL oxidation in vitro (with a potency 16.3 times that of probucol) and attenuated HAEC‐mediated LDL oxidation as well as reactive oxygen species (ROS) production. In cholesterol‐fed New Zealand White rabbits (with probucol as positive control), Sal B intake reduced Cu²⁺‐induced LDL oxidation, lipid deposition in the thoracic aorta, intimal thickness of the aortic arch and thoracic aorta and neointimal formation in the abdominal aorta. CONCLUSION: The data obtained in this study suggest that Sal B protects HAECs from oxidative injury‐mediated cell death via inhibition of ROS production. The antioxidant activity of Sal B may help explain its efficacy in the treatment of vascular diseases. Copyright © 2010 Society of Chemical Industry     

Sex Differences in the Triad of Acquired Sensorineural Hearing Loss

The triad of noise-generated, drug-induced, and age-related hearing loss is the major cause of acquired sensorineural hearing loss (ASNHL) in modern society. Although these three forms of hearing loss display similar underlying mechanisms, detailed studies have revealed the presence of sex differences in the auditory system both in human and animal models of ASNHL. However, the sexual dimorphism of hearing varies among noise-induced hearing loss (NIHL), ototoxicity, and age-related hearing loss (ARHL). Importantly, estrogen may play an essential role in modulating the pathophysiological mechanisms in the cochlea and several reports have shown that the effects of hormone replacement therapy on hearing loss are complex. This review will summarize the clinical features of sex differences in ASNHL, compare the animal investigations of cochlear sexual dimorphism in response to the three insults, and address how estrogen affects the auditory organ at molecular levels.     

Scanning Probe Lithography Patterning of Monolayer Semiconductors and Application in Quantifying Edge Recombination

Scanning probe lithography is used to directly pattern monolayer transition metal dichalcogenides (TMDs) without the use of a sacrificial resist. Using an atomic‐force microscope, a negatively biased tip is brought close to the TMD surface. By inducing a water bridge between the tip and the TMD surface, controllable oxidation is achieved at the sub‐100 nm resolution. The oxidized flake is then submerged into water for selective oxide removal which leads to controllable patterning. In addition, by changing the oxidation time, thickness tunable patterning of multilayer TMDs is demonstrated. This resist‐less process results in exposed edges, overcoming a barrier in traditional resist‐based lithography and dry etch where polymeric byproduct layers are often formed at the edges. By patterning monolayers into geometric patterns of different dimensions and measuring the effective carrier lifetime, the non‐radiative recombination velocity due to edge defects is extracted. Using this patterning technique, it is shown that selenide TMDs exhibit lower edge recombination velocity as compared to sulfide TMDs. The utility of scanning probe lithography towards understanding material‐dependent edge recombination losses without significantly normalizing edge behaviors due to heavy defect generation, while allowing for eventual exploration of edge passivation schemes is highlighted, which is of profound interest for nanoscale electronics and optoelectronics.     

Redshifting and broadening of quantum-well infrared photodetector'sresponse via impurity-free vacancy disordering

The partial intermixing of the well and barrier materials offers unique opportunities to shift locally the bandgap of quantum-well (QW) structures. We have demonstrated redshifting and broadening of the wavelength responses of bound-to-continuum GaAs and InP based quantum-well infrared photodetectors (QWIP's) after growth via impurity-free vacancy disordering (IFVD). A comprehensive set of experiments is conducted on QWIP's fabricated from both as-grown and multiple-quantum-well (MQW) structures. Compared to the as-grown detector, the peak spectral responses of the disordered detectors were shifted to longer wavelengths. The peak absolute response of the disordered GaAs based QWIP is lower by almost a factor of four. However, the responsivity characteristics of the disordered InP based QWIP show no major degradation. In general, with the spectral broadening taken into account, the overall performance of the disordered QWIP's has not dropped significantly. Thus, the postgrowth control of the QW composition profiles by impurity-free vacancy disordering offers unique opportunities to fine tune various aspects of a photodetector's response. Theoretical calculations of the absorption coefficient spectrum are in excellent agreement with the experimental data     

Low‐Voltage Operational,Low‐Power Consuming,and High Sensitive Tactile Switch Based on 2D Layered InSe Tribotronics

Electronics based on layered indium selenide (InSe) channels exhibit promising carrier mobility and switching characteristics. Here, an InSe tribotronic transistor (denoted as w/In InSe T‐FET) obtained through the vertical combination of an In‐doped InSe transistor and triboelectric nanogenerator is demonstrated. The w/In InSe T‐FET can be operated by adjusting the distance between two triboelectrification layers, which generates a negative electrostatic potential that serves as a gate voltage to tune the charge carrier transport behavior of the InSe channel. Benefiting from the surface charging doping of the In layer, the w/In InSe T‐FET exhibits high reliability and sensitivity with a large on/off current modulation of 10⁶ under a low drain–source voltage of 0.1 V and external frictional force. To demonstrate its function as a power‐saving tactile sensor, the w/In InSe T‐FET is used to sense “INSE” in Morse code and power on a light‐emitting diode. This work reveals the promise of 2D material–based tribotronics for use in nanosensors with low power consumption as well as in intelligent systems.     

Reversible and Precisely Controllable p/n‐Type Doping of MoTe2 Transistors through Electrothermal Doping

Precisely controllable and reversible p/n‐type electronic doping of molybdenum ditelluride (MoTe₂) transistors is achieved by electrothermal doping (E‐doping) processes. E‐doping includes electrothermal annealing induced by an electric field in a vacuum chamber, which results in electron (n‐type) doping and exposure to air, which induces hole (p‐type) doping. The doping arises from the interaction between oxygen molecules or water vapor and defects of tellurium at the MoTe₂ surface, and allows the accurate manipulation of p/n‐type electrical doping of MoTe₂ transistors. Because no dopant or special gas is used in the E‐doping processes of MoTe₂, E‐doping is a simple and efficient method. Moreover, through exact manipulation of p/n‐type doping of MoTe₂ transistors, quasi‐complementary metal oxide semiconductor adaptive logic circuits, such as an inverter, not or gate, and not and gate, are successfully fabricated. The simple method, E‐doping, adopted in obtaining p/n‐type doping of MoTe₂ transistors undoubtedly has provided an approach to create the electronic devices with desired performance.     

A Nanostructuring Method to Decouple Electrical and Thermal Transport through the Formation of Electrically Triggered Conductive Nanofilaments

Transforming thermal energy into electric energy and vice versa needs the decoupling of electrical transport from thermal transport. An innovative strategy is proposed by forming/disrupting electrically triggered conductive nanofilaments within semiconducting thin films to switch thermoelectric properties between two states without further material modification and manufacturing processes. It can also controllably adjust the degree of decoupling, providing a potential resolution and performance adjustability for heat/coldness control or power consumption reduction on demand.     

Photoactive Electro-Controlled Visual Perception Memory for Emulating Synaptic Metaplasticity and Hebbian Learning

In bionic technology, it has become an innovative process imitating the functionality and structuralism of human biological systems to exploit advanced artificial intelligent machines. Bionics plays a significant role in environmental protection, especially for its low energy loss. By fusing the concept of receptor-like sensing component and synapse-like memory, the photoactive electro-controlled optical sensory memory (PE-SM) is proposed and realized in a single device, which endows a simple methodology of reducing power consumption by photoactive electro-control. The PE-SM is the system built with the stacked atomically thick materials, in which rhenium diselenide serves as a robust photosensor, hexagonal boron nitride serves as a tunneling dielectric, and graphene serves as a charge-storage layer. With the features of the PE-SM, it performs synaptic metaplasticities under optical spikes. In addition, a simulated spiking neural network composed of 24 × 24 PE-SMs is further presented in an unsupervised machine learning environment, performing image recognition via the Hebbian rule. The PE-SM not only improves the neuromorphic computing efficiency but also simplifies the circuit-size structure. Eventually, the concept of photoactive electro-control can extend to other photosensitive 2D materials and provide a new approach of constructing either visual perception memory or photonic synaptic devices.     

Amino-formaldehyde resins. Analysis by application of a mannich type reaction

The formation of Mannich bases from secondary aliphatic amines and primary alkoxymethyl compounds of urea and melamine in basic media have been studied. The rate of formation of the Mannich base is equal to the rate of decomposition of the alkoxymethyl compound. This is explained by a reaction of the amine with the Schiff base, the intermediate formed during the alkoxymethyl decomposition. In a mixture of primary alkoxymethyl and hydroxymethyl compounds of urea and melamine, the amine reacts almost selectively with the alkoxymethyl compound. An analytical method for the determination of primary dimethylene ether groups of primary alkoxymethyl groups in mixture with hydroxymethyl groups is developed.