Support Vector Machine Applications in Terahertz Pulsed Signals Feature Sets

In the past decade, terahertz radiation (T-rays) have been extensively applied within the fields of industrial and biomedical imaging, owing to their noninvasive property. Support vector machine (SVM) learning algorithms are sufficiently powerful to detect patterns hidden inside noisy biomedical measurements. This paper introduces a frequency orientation component method to extract T-ray feature sets for the application of two- and multiclass classification using SVMs. Effective discriminations of ribonucleic acid (RNA) samples and various powdered substances are demonstrated. The development of this method has become important in T-ray chemical sensing and image processing, which results in enhanced detectability useful for many applications, such as quality control, security detection and clinic diagnosis.     

Tailoring the interfaces between nematic liquid crystal emulsions and aqueous phases via layer-by-layer assembly

We report the assembly of polyelectrolyte multilayer (PEM) films at the interfaces of thermotropic liquid crystal (LC) droplets dispersed in an aqueous phase. Exposure of PEM-coated droplets to surfactant slowed the bipolar-to-radial ordering transition of the LCs by 2 orders of magnitude relative to naked droplets. This shows that PEMs can be used to influence the interactions of analytes with the LC cores of the droplets, allowing tuning of the LC emulsion sensing properties.     

Apertureless near-field/far-field CW two-photon microscope for biological and material imaging and spectroscopic applications

We present the development of a versatile spectroscopic imaging tool to allow for imaging with single-molecule sensitivity and high spatial resolution. The microscope allows for near-field and subdiffraction-limited far-field imaging by integrating a shear-force microscope on top of a custom inverted microscope design. The instrument has the ability to image in ambient conditions with optical resolutions on the order of tens of nanometers in the near field. A single low-cost computer controls the microscope with a field programmable gate array data acquisition card. High spatial resolution imaging is achieved with an inexpensive CW multiphoton excitation source, using an apertureless probe and simplified optical pathways. The high-resolution, combined with high collection efficiency and single-molecule sensitive optical capabilities of the microscope, are demonstrated with a low-cost CW laser source as well as a mode-locked laser source.     

The kinetics of conductivity type conversion in HgCdTe by ion beam milling

It is well established that dry etching of HgCdTe by Ar ion-beam milling (IBM) converts vacancy-doped p-type HgCdTe to n-type. Less well established is the understanding of the observed rate of conversion. This paper shows that the observed variations of the depth of conversion with milling time can be accounted for in terms of two rate processes operating in tandem. The first process is the diffusion of Hg interstitials from the surface to the conversion boundary followed by the second, or conversion, process that is the capture of the Hg interstitials by cation vacancies. Assuming steady-state conditions exist a quadratic equation is derived for the conversion depth and its milling-time dependence for two cases: when the initial p-type layer is electrically intrinsic at the milling temperature and when it is extrinsic. Good agreement is found with the available experimental Ar-ion-milling data. Good agreement is also found for type conversion due to etching with a radio-frequency Ar plasma. The effect of capture of Hg interstitials by traps, in addition to capture by cation vacancies, is also considered.     

Slip-enhanced electrokinetic energy conversion in nanofluidic channels

We investigate theoretically the influence of hydrodynamic slip at the surface of a nanofluidic channel on the efficiency with which electrokinetic phenomena can be used to convert hydrostatic energy to electrical power. Slip is introduced by applying the Navier boundary condition to the pressure-driven and the electro-osmotic components of the fluid velocity. A strong enhancement in the efficiency is predicted for increasing slip length due to the resulting decrease in the fluidic impedance and increase in the streaming conductance. These effects are moderated by a decrease in the electrical impedance, which promotes dissipation. The maximum efficiency approaches 100% as the slip length diverges, and a potentially practical 40% efficiency is expected for a moderate 30?nm slip length in a 10?nm high channel. Recently reported slip lengths for carbon nanotube filters suggest that efficiencies above 70% and high power densities might be achieved in a graphitic system.     

Engineering the morphology of a self-assembling protein fibre

Biological assemblies provide inspiration for the development of new materials for a variety of applications. Our ability to realize this potential, however, is hampered by difficulties in producing and engineering natural biomaterials, and in designing them de novo. We previously described a self-assembling system comprising two short complementary segments of straight synthetic polypeptides (termed standards in this report). Their interaction results in the formation of long fibres--about 50 nm in diameter--that extend straight and without branching for tens to hundreds of micrometres. Our aim is to influence and, ultimately, to control fibre morphology. Here, we show that the standard peptides can be supplemented with special peptides to effect morphological changes in the fibres. Specifically, we created half-sized subunits of the standard peptides, which were combined to make nonlinear peptides. When mixed with the standard peptides, these nonlinear peptides produced kinked, waved and branched fibres. We related the numbers of these features to the special/standard ratios empirically. Furthermore, the extent and frequency of kinking was altered by changing the standard-fibre background: more kinking was observed in a background of thinner, less-stable fibres. The ability to perform such transformations holds promise for bottom-up assembly and engineering responsive biomimetic materials for applications in surface and tissue engineering.     

Design of miniaturized RF SAW duplexer package

This paper provides a comprehensive methodology for accurate analysis and design of miniaturized radio frequency (RF) surface acoustic wave (SAW) duplexer package. Full-wave analysis based on the three dimensional (3-D) finite element method (FEM) is applied to get the package model. The die model is obtained by combining the parasitics and acoustics models. The modeling of bonding wire is also discussed. The models of package, die, and bonding wires are assembled together to get the total response. Based on this methodology, several novel ideas are proposed to significantly improve the isolation. Simulation and measurement results are compared, and excellent agreement is found. The technique developed in this paper reduces the design cycle time greatly and can be applied to various RF SAW device packages.     

Anthropocene streams and base-level controls from historic dams in the unglaciated mid-Atlantic region, USA

Recently, widespread valley-bottom damming for water power was identified as a primary control on valley sedimentation in the mid-Atlantic US during the late seventeenth to early twentieth century. The timing of damming coincided with that of accelerated upland erosion during post-European settlement land-use change. In this paper, we examine the impact of local drops in base level on incision into historic reservoir sediment as thousands of ageing dams breach. Analysis of lidar and field data indicates that historic milldam building led to local base-level rises of 2-5 m (typical milldam height) and reduced valley slopes by half. Subsequent base-level fall with dam breaching led to an approximate doubling in slope, a significant base-level forcing. Case studies in forested, rural as well as agricultural and urban areas demonstrate that a breached dam can lead to stream incision, bank erosion and increased loads of suspended sediment, even with no change in land use. After dam breaching, key predictors of stream bank erosion include number of years since dam breach, proximity to a dam and dam height. One implication of this work is that conceptual models linking channel condition and sediment yield exclusively with modern upland land use are incomplete for valleys impacted by milldams. With no equivalent in the Holocene or late Pleistocene sedimentary record, modern incised stream-channel forms in the mid-Atlantic region represent a transient response to both base-level forcing and major changes in land use beginning centuries ago. Similar channel forms might also exist in other locales where historic milling was prevalent.     

Examining improved experimental designs for wind tunnel testing using Monte Carlo sampling methods

Wind tunnels are used in the design and testing of a wide variety of systems and products. Wind tunnel test campaigns involve a large number of experimental data points, can take a long time to accomplish, and can consume tremendous resources. Design of Experiments is a systematic, statistically based approach to experimental design and analysis that has the potential to improve the efficiency and effectiveness of wind tunnel testing. In Defense Acquisition, wind tunnel testing of aircraft systems may require years of effort to fully characterize the system of interest. We employ data from a fairly large legacy wind tunnel test campaign and compare that data's corresponding response surface to the response surfaces derived from data generated using smaller, statistically motivated experimental design strategies. The comparison is accomplished using a Monte Carlo sampling methodology coupled with a statistical comparison of the system's estimated response surfaces. Initial results suggest a tremendous opportunity to reduce wind tunnel test efforts without losing test information. Published in 2010 by John Wiley & Sons, Ltd.     

Label-free electrochemical monitoring of concentration enrichment during bipolar electrode focusing

We show that a label-free electrochemical method can be used to monitor the position of an enriched analyte band during bipolar electrode focusing in a microfluidic device. The method relies on formation of a depleted buffer cation region, which is responsible for concentration enrichment of the charged analyte. However, this depletion region also leads to an increase in the local electric field in the solution near a bipolar electrode (BPE), and this in turn results in enhanced faradaic reactions (oxidation and reduction of water) at the BPE. Therefore, it is possible to detect the presence of the concentrated analyte band by measuring the current passing through the BPE used for concentration enrichment, or the concentrated band can be detected at a secondary BPE dedicated to that purpose. Both experiments and simulations are presented that fully elucidate the underlying phenomenon responsible for these observations.