全文获取类型
收费全文 | 1700篇 |
免费 | 164篇 |
国内免费 | 5篇 |
专业分类
电工技术 | 18篇 |
综合类 | 2篇 |
化学工业 | 507篇 |
金属工艺 | 17篇 |
机械仪表 | 42篇 |
建筑科学 | 63篇 |
矿业工程 | 2篇 |
能源动力 | 72篇 |
轻工业 | 318篇 |
水利工程 | 22篇 |
石油天然气 | 11篇 |
无线电 | 102篇 |
一般工业技术 | 231篇 |
冶金工业 | 89篇 |
原子能技术 | 4篇 |
自动化技术 | 369篇 |
出版年
2024年 | 10篇 |
2023年 | 27篇 |
2022年 | 84篇 |
2021年 | 112篇 |
2020年 | 63篇 |
2019年 | 79篇 |
2018年 | 94篇 |
2017年 | 96篇 |
2016年 | 117篇 |
2015年 | 73篇 |
2014年 | 101篇 |
2013年 | 152篇 |
2012年 | 123篇 |
2011年 | 148篇 |
2010年 | 76篇 |
2009年 | 74篇 |
2008年 | 83篇 |
2007年 | 67篇 |
2006年 | 57篇 |
2005年 | 35篇 |
2004年 | 31篇 |
2003年 | 24篇 |
2002年 | 30篇 |
2001年 | 12篇 |
2000年 | 7篇 |
1999年 | 12篇 |
1998年 | 17篇 |
1997年 | 15篇 |
1996年 | 15篇 |
1995年 | 4篇 |
1994年 | 2篇 |
1993年 | 6篇 |
1991年 | 1篇 |
1990年 | 3篇 |
1989年 | 3篇 |
1988年 | 3篇 |
1987年 | 3篇 |
1985年 | 4篇 |
1981年 | 3篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
排序方式: 共有1869条查询结果,搜索用时 11 毫秒
61.
Diego Bailetti Federica Sentinelli Sabrina Prudente Flavia Agata Cimini Ilaria Barchetta Maria Totaro Alessia Di Costanzo Arcangelo Barbonetti Frida Leonetti Maria Gisella Cavallo Marco Giorgio Baroni 《International journal of molecular sciences》2022,23(3)
Type 2 diabetes is characterized by impairment in insulin secretion, with an established genetic contribution. We aimed to evaluate common and low-frequency (1–5%) variants in nine genes strongly associated with insulin secretion by targeted sequencing in subjects selected from the extremes of insulin release measured by the disposition index. Collapsing data by gene and/or function, the association between disposition index and nonsense variants were significant, also after adjustment for confounding factors (OR = 0.25, 95% CI = 0.11–0.59, p = 0.001). Evaluating variants individually, three novel variants in ARAP1, IGF2BP2 and GCK, out of eight reaching significance singularly, remained associated after adjustment. Constructing a genetic risk model combining the effects of the three variants, only carriers of the ARAP1 and IGF2BP2 variants were significantly associated with a reduced probability to be in the lower, worst, extreme of insulin secretion (OR = 0.223, 95% CI = 0.105–0.473, p < 0.001). Observing a high number of normal glucose tolerance between carriers, a regression posthoc analysis was performed. Carriers of genetic risk model variants had higher probability to be normoglycemic, also after adjustment (OR = 2.411, 95% CI = 1.136–5.116, p = 0.022). Thus, in our southern European cohort, nonsense variants in all nine candidate genes showed association with better insulin secretion adjusted for insulin resistance, and we established the role of ARAP1 and IGF2BP2 in modulating insulin secretion. 相似文献
62.
Andrea Bianconi Gelsomina Aruta Francesca Rizzo Luca Francesco Salvati Pietro Zeppa Diego Garbossa Fabio Cofano 《International journal of molecular sciences》2022,23(8)
Despite the multidisciplinary management in the treatment of glioblastomas, the average survival of GBM patients is still 15 months. In recent years, molecular biomarkers have gained more and more importance both in the diagnosis and therapy of glial tumors. At the same time, it has become clear that non neoplastic cells, which constitute about 30% of glioma mass, dramatically influence tumor growth, spread, and recurrence. This is the main reason why, in recent years, scientific research has been focused on understanding the function and the composition of tumor microenvironment and its role in gliomagenesis and recurrence. The aim of this review is to summarize the most recent discovery about resident microglia, tumor-associated macrophages, lymphocytes, and the role of extracellular vesicles and their bijective interaction with glioma cells. Moreover, we reported the most recent updates about new therapeutic strategies targeting immune system receptors and soluble factors. Understanding how glioma cells interact with non-neoplastic cells in tumor microenvironment is an essential step to comprehend mechanisms at the base of disease progression and to find new therapeutic strategies for GBM patients. However, no significant results have yet been obtained in studies targeting single molecules/pathways; considering the complex microenvironment, it is likely that only by using multiple therapeutic agents acting on multiple molecular targets can significant results be achieved. 相似文献
63.
Yeudy F. Vargas Alzate Lluis G. Pujades Beneit Alex H. Barbat Jorge E. Hurtado Gomez Sergio A. Diaz Alvarado Diego A. Hidalgo Leiva 《Structure and Infrastructure Engineering》2018,14(6):817-829
Most of buildings and structures are usually projected according to two main axes. However, the geographical position of these buildings varies randomly. Such random distributions of the azimuthal positions of structures, in most of the cities, generally, are not accounted for when assessing their seismic risk; certainly, the direction of the seismic loads is another highly random variable. Moreover, an additional important source of uncertainty is related to the structural response, mainly due to the random character of the mechanical properties. There is a consensus that uncertainties must be considered for adequately assessing the seismic risk of structures, but these directionality effects have not been deeply explored so far. In this article, the influence of the high uncertainty involved in these input variables on the expected seismic damage is analysed. Thus, an actual earthquake, which affected the southern part of Spain, is studied. Notably, damages on a group of affected buildings, located close to the epicentre, are analysed and discussed in detail. The results show that the influence of the random azimuthal position of structures is an important source of uncertainty and that it should be taken into account when estimating the expected seismic risk in urban areas. 相似文献
64.
65.
The Journal of Supercomputing - 相似文献
66.
de Diego Isaac Martín Román Ignacio San Montero Javier Cano Conde Cristina Cabello Enrique 《Multimedia Tools and Applications》2019,78(13):17437-17459
Multimedia Tools and Applications - This paper presents a novel distributed intelligent video surveillance architecture based on Wireless Multimedia Sensor Networks (WMSNs). This architecture is... 相似文献
67.
Mangili Patrick V. Junqueira Pedro G. Santos Lizandro S. Prata Diego M. 《Clean Technologies and Environmental Policy》2019,21(5):1073-1090
Clean Technologies and Environmental Policy - Maleic anhydride may be obtained from different technological routes, being the selective oxidation of benzene and oxidation of butane the only ones... 相似文献
68.
69.
Chemical composition and antioxidant properties of Laurus nobilis L. and Myrtus communis L. essential oils from Morocco and evaluation of their antimicrobial activity acting alone or in combined processes for food preservation 总被引:1,自引:0,他引:1 下载免费PDF全文
70.
Daniel Fernández-Quiroz Jorge Loya-Duarte Erika Silva-Campa Waldo Argüelles-Monal Andre-í Sarabia-Sainz Armando Lucero-Acuña Teresa del Castillo-Castro Julio San Román Jaime Lizardi-Mendoza Alexel J. Burgara-Estrella Beatriz Castaneda Diego Soto-Puebla Martín Pedroza-Montero 《应用聚合物科学杂志》2019,136(32):47831
This work describes the preparation of thermosensitive chitosan-graft-poly(N-vinylcaprolactam) nanoparticles by ionic gelation and their potential use as a controlled drug delivery system, using doxorubicin as a model drug. A systematic study of the effect of the main processing parameters on both the size and thermoresponsive behavior of nanoparticles was investigated. The size of the particles is strongly dependent on the length of the poly(N-vinylcaprolactam) grafted chains and the concentration of the copolymer and crosslinking agent solutions. The molecular structure of the copolymer plays an essential role in the phase transition temperature of the particles, which decreases with the length of PVCL grafted chain. The system displayed proper drug-association parameters, and the drug-loaded nanoparticles exhibited dose-dependent cytotoxicity. A significant increase in the doxorubicin delivery rate was observed above the phase transition temperature (40 °C). These features indicate that these nanoparticles are suitable for the development of a new thermally controlled anti-cancer drug delivery system. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136, 47831. 相似文献