Interleukin-6-type cytokines in vivo: regulated bioavailability

Investigators have traditionally thought of the class of inflammation- and injury-associated cytokines in large part as "free" entities in the peripheral circulation. In the case of interleukin-6 (IL-6), the cytokine can be found in blood in complexes of molecular mass 400-500, 150-200, and 25-35 kDa in association with binding proteins that can include soluble IL-6 receptor (sIL-6R), anti-IL-6, and anti-sIL-6R IgG, and others. Sustained high levels of different particular IL-6 complexes are observed in the human circulation in cancer patients subjected to particular active anticancer immunotherapy regimens. In the "chaperoned" state, circulating IL-6 complexes display differential immunoreactivity in different ELISAs and possess differential biological activity as assayed ex vivo. The discovery of "chaperoned" circulating IL-6 in humans points to a new level of modulation of cytokine function, that of regulated bioavailability of IL-6 in vivo.     

Harnessing graphics processors for the fast computation of acoustic likelihoods in speech recognition

In large vocabulary continuous speech recognition (LVCSR) the acoustic model computations often account for the largest processing overhead. Our weighted finite state transducer (WFST) based decoding engine can utilize a commodity graphics processing unit (GPU) to perform the acoustic computations to move this burden off the main processor. In this paper we describe our new GPU scheme that can achieve a very substantial improvement in recognition speed whilst incurring no reduction in recognition accuracy. We evaluate the GPU technique on a large vocabulary spontaneous speech recognition task using a set of acoustic models with varying complexity and the results consistently show by using the GPU it is possible to reduce the recognition time with largest improvements occurring in systems with large numbers of Gaussians. For the systems which achieve the best accuracy we obtained between 2.5 and 3 times speed-ups. The faster decoding times translate to reductions in space, power and hardware costs by only requiring standard hardware that is already widely installed.     

Plans, Actions and Dialogues Using Linear Logic

We describe how Intuitionistic Linear Logic can be used to provide a unified logical account for agents to find and execute plans. This account supports the modelling of agent interaction, including dialogue; allows agents to be robust to unexpected events and failures; and supports significant reuse of agent specifications. The framework has been implemented and several case studies have been considered. Further applications include human–computer interfaces as well as agent interaction in the semantic web.     

Characterizing the Nash equilibria of a three-player Bayesian quantum game

Quantum games with incomplete information can be studied within a Bayesian framework. We consider a version of prisoner’s dilemma (PD) in this framework with three players and characterize the Nash equilibria. A variation of the standard PD game is set up with two types of the second prisoner and the first prisoner plays with them with probability p and \(1-p\), respectively. The Bayesian nature of the game manifests in the uncertainty that the first prisoner faces about his opponent’s type which is encoded either in a classical probability or in the amplitudes of a wave function. Here, we consider scenarios with asymmetric payoffs between the first and second prisoner for different values of the probability, p, and the entanglement. Our results indicate a class of Nash equilibria (NE) with rich structures, characterized by a phase relationship on the strategies of the players. The rich structure can be exploited by the referee to set up rules of the game to push the players toward a specific class of NE. These results provide a deeper insight into the quantum advantages of Bayesian games over their classical counterpart.     

Contextual factors affecting task distribution in two participatory ergonomic interventions: a qualitative study

This article provides an analysis of the evolution of the division of labour in participatory ergonomics (PE) programmes in two worksites. The analysis is based on interviews and field observations in the worksites. In both settings there was meaningful participation by both worker and management members of ergonomic change teams (ECTs) in the hazard assessment and solution identification stages, but as the teams moved to the implementation stage, worker representatives were marginalised and the participatory nature of the programmes was severely curtailed. The removal of workers from the process was the outcome of the interplay among the type of activities pursued in the implementation stage, the skills and knowledge required to carry out those activities, and workers' limited influence in the organisational hierarchies. Findings highlight the salience of the social context in which participatory programmes are located and the importance of examining participatory programmes as they evolve over time. STATEMENT OF RELEVANCE: This article contributes to a growing literature on the process and implementation of PE programmes. The article's focus on social and organisational factors that affect the division of labour and attention to the evolution of involvement over time extend current understandings of participation in ergonomics programmes.     

Comments on “Adaptive variable structure set-point control ofunderactuated robots” [and reply]

This note points out several technical errors in the above mentioned paper by Su et al. (ibid. vol.44 (1999)). It is shown that the choice of Lyapunov function is inadequate for the system stability analysis, and the asymptotic tracking of the underactuated robot joints is not achievable under certain conditions. In reply, Su addresses, from the comments, some important issues that were not duly emphasised in the paper     

Robust tracking control of an array of nanoparticles moving on a substrate

Control of nanosystems with frictional dynamics using feedback control methods is important to a wide range of applications of nanotribology. This paper studies the tracking control problem of an array of nanoparticles moving on a substrate with friction between the substrate and the particles. The focus of this study is on control design and stability analysis. The major challenges in this problem include nonlinearities and uncertainties in the frictional dynamics and limited availability of measurable states in nanosystems. The particle–substrate interaction is considered to be unknown, and the unknown effect of unmodeled particle dynamics on the dynamics of the center of mass of the array is also considered. A nonlinear identifier is first developed to identify these unmodeled dynamics. A feedback controller is then developed based on the identifier to control the center of mass of the particles to track a desired trajectory. Boundedness of the closed-loop states and semiglobal asymptotic stability of the tracking error are proven using Lyapunov theory for the case of linear inter-particle interactions. An example with more general Morse-type inter-particle interactions is included to provide some level of confidence that the results are general but not assuredness that they are. Numerical simulation results are provided to demonstrate the performance of the developed identification and control law.     

Sublethal concentrations of mercury in river otters: monitoring environmental contamination

Hair, muscle, and liver mercury concentrations were determined in river otter (Lutra canadensis) carcasses collected from the lower coastal plain and piedmont of Georgia. Mean muscle and hair mercury concentrations were greater (P < 0.001) in otters from the lower coastal plain (4.42 and 24.25 mg/kg wet wt, respectively) compared to otters from the piedmont (1.48 and 15.24 mg/kg, respectively). Liver tissue from lower coastal plain otters averaged 7.53 mg/kg mercury. Mean fetus brain and muscle mercury concentrations were 1.03 and 1.58 mg/kg wet wt, respectively, and fetal muscle mercury concentrations were correlated (r = 0.92) with maternal muscle mercury concentrations. Comparison of mercury concentrations found in Georgia otters to those associated with adverse effects in otter and mink (Mustela vison), indicate sublethal contamination with concentrations in some individuals approaching that observed in experimentally dosed individuals that developed clinical signs of mercurialism. Mercury concentrations in fish from the lower coastal plain approached or exceeded concentrations demonstrated to be toxic to experimentally dosed otters.