Intelligent planning and the design of a new risk-based,intelligent flight plan

A safe flight starts with effective performance of the pre-flight flight planning and briefing task. However, several problems related to the execution of this task can be identified. Potentially, the introduction of an improved flight plan provides an opportunity to improve the quality and availability of information provided to Flight Crew, thereby enhancing the quality of crew briefings. The proposed risk-based, intelligent flight plan is designed from the perspective of the current operational concept (e.g. fixed routes and ATC managerial role for separation), and associated airline Flight Planning and Dispatch functions. In this case, the focus is sharing information across specific airline stakeholders (e.g. Flight Operations Management and Safety functions) and Maintenance, to support a safe and efficient flight operation. Overall, the introduction of this new flight plan will result in the definition of new operational and organisational processes, along with a new way of performing the pre-flight, planning and briefing task. It is anticipated that this will impact positively on the operational and safety outcome of the flight.     

Approximation for scheduling on uniform nonsimultaneous parallel machines

We consider the problem of scheduling on uniform machines which may not start processing at the same time with the purpose of minimizing the maximum completion time. We propose using a variant of the MULTIFIT algorithm, LMULTIFIT, which generates schedules which end within 1.382 times the optimal maximum completion time for the general problem, and within \(\sqrt{6}/2\) times the optimal maximum completion time for problem instances with two machines. Both developments represent improvements over previous results. We prove that LMULTIFIT worst-case bounds for scheduling on simultaneous uniform machines are also LMULTIFIT worst-case approximation bounds for scheduling on nonsimultaneous uniform machines and show that worst-case approximation bounds of MULTIFIT variants for simultaneous uniform machines from previous literature also apply to LMULTIFIT. We also comment on how a PTAS for scheduling on a constant number of uniform machines with fixed jobs can be used to obtain a PTAS for scheduling on a constant number of uniform nonsimultaneous parallel machines.     

SEBS elastomers for fabrication of microfluidic devices with reduced drug absorption by injection molding and extrusion

The majority of microfluidic devices used for cell culture, including Organ-on-a-Chips (Organ Chips), are fabricated using polydimethylsiloxane (PDMS) polymer because it is flexible, optically clear, and easy to mold. However, PDMS possesses significant challenges for high volume manufacturing and its tendency to absorb small hydrophobic compounds limits its usefulness as a material in devices used for drug evaluation studies. Here, we demonstrate that a subset of optically clear, elastomeric, styrenic block copolymers based on styrene-ethylene-butylene-styrene exhibit reduced absorption of small hydrophobic molecules and drug compounds compared to PDMS and that they can be fabricated into microfluidic devices with fine features and the flexibility required for Organ Chips using mass production techniques of injection molding and extrusion.     

Effective visualization of complex vascular structures using a non-parametric vessel detection method

The effective visualization of vascular structures is critical for diagnosis, surgical planning as well as treatment evaluation. In recent work, we have developed an algorithm for vessel detection that examines the intensity profile around each voxel in an angiographic image and determines the likelihood that any given voxel belongs to a vessel; we term this the "vesselness coefficient" of the voxel. Our results show that our algorithm works particularly well for visualizing branch points in vessels. Compared to standard Hessian based techniques, which are fine-tuned to identify long cylindrical structures, our technique identifies branches and connections with other vessels. Using our computed vesselness coefficient, we explore a set of techniques for visualizing vasculature. Visualizing vessels is particularly challenging because not only is their position in space important for clinicians but it is also important to be able to resolve their spatial relationship. We applied visualization techniques that provide shape cues as well as depth cues to allow the viewer to differentiate between vessels that are closer from those that are farther. We use our computed vesselness coefficient to effectively visualize vasculature in both clinical neurovascular x-ray computed tomography based angiography images, as well as images from three different animal studies. We conducted a formal user evaluation of our visualization techniques with the help of radiologists, surgeons, and other expert users. Results indicate that experts preferred distance color blending and tone shading for conveying depth over standard visualization techniques.     

Triton X-100 pretreatment of LR-white thin sections improves immunofluorescence specificity and intensity

The staining of intracellular antigenic sites in postembedded samples is a challenging problem. Deterioration of antigenicity and limited antibody accessibility to the antigen are commonly encountered on account of processing steps. In this study preservation of the antigen was achieved by fixing the tissues with mild fixatives, performing partial dehydration, and embedding in a low crosslinked hydrophilic acrylic resin, LR-White. Permeabilization of cell membranes with Triton X-100 is well documented but can affect some antigen conformations. We tested the effect of Triton X-100 on the ED1 antigen present in the lysosomal membrane of the macrophage in cell culture. The ED1 antigen in the lysosome was resistant to extraction by Triton X-100. Interestingly pretreating the LR-White sections of macrophage pellets with Triton X-100 improved the staining intensity of ED1. The most intense and clear specific fluorescent staining was observed when sections were pretreated with 0.2% Triton X-100 for 2 min. Longer exposure of sections to 0.2% Triton or 2 min exposure to 2% Triton lead to reduced ED1 labeling. SEM observations indicated that the detergent extracted a component from the cells and not the resin and was determined to be lipid. This novel technique could be applied in many research areas where postembedding fluorescent immunolabeling with higher labeling intensity is desired.     

Negotiating participation: understanding the "how" in an ergonomic change team

In participatory ergonomic (PE) interventions, "how" effective participation by workplace parties can be achieved remains unclear. We conducted a case study of the dynamics of an ergonomic change team (ECT) process in a medium-sized (175 employees) automotive foam manufacturing plant. We present analyses of observer field notes and post-intervention interviews from which key elements on the dynamics of the "how" emerged: (1) impacts of facilitators' involvement and interests; (2) tensions in delimiting the scope of ECT activities; issues around (3) managing meetings and (4) realizing labour and management participation; and (5) workplace ECT members' difficulties in juggling other job commitments and facing production pressures. We highlight the ongoing negotiated nature of responses to these challenges by labour, management and ergonomic facilitator members of the ECT. We argue for greater examination of the social dynamics of PE processes to identify additional ways of fostering participation in ergonomic project implementation.     

Towards the implementation of text and discourse theory in computer-assisted textual analysis

Humanities computing (HC) has failed to integrate into its practices many of the key theoretical elements of contemporary text and discourse theory. This has in turn contributed to the marginalization of HC in research and teaching. Outdated theoretical models must be abandoned in order to develop a critical discourse based on the insights of HC. HC projects remain far too attached to micro-analyses and have not developed the theoretical and methodological tools necessary to undertake systemic macro-analyses on the level of discourse. Given that texts are a mixture of determinate and dynamic systems, recent developments in chaos theory may be of help in modelling the interrelationship of these elements at discourse level.Donald Bruce is Associate Professor of Romance Languages at the University of Alberta. His research interests include literary theory, XIXth century French literature, science and literature, and translation. He recently edited an issue ofRecherches Sémiotiques/Semiotic Inquiry on Literature and Ideology and is presently working on a project entitled,The Socio-semiotic Nexus: Jules Vallès and the Discourse of the Commune.     

A Framework and Lightweight Protocol for Multimedia Network Management

The increasing complexities of modern networks coupled with the popularity of multimedia applications have placed higher demands on network managers. This paper reviews the main requirements and challenges for effective management of multimedia networks, presents a case study of a thin-client-based multimedia system called CSL (Computer-supported Learning System) and proposes a framework for managing such networks. CSL delivers browser-based assessments and other learning materials to thousands of students at the University of Auckland. This type of demand requires more flexible schemes for the management of the network. In the framework proposed, most of the link management information will be kept in a MIB in the network and a very simple MIB will be maintained in the thin client. The MIB in the network is accessible to the network management application, and a lightweight protocol is proposed for updating of the network MIB using an agent at the thin client.     

Identification of the female-produced sex pheromone of the scarab beetle,Hoplia equina

Hoplia equina LeConte (Coleoptera: Scarabaeidae: Melolonthinae) is a beetle pest of cranberry beds in Massachusetts. Larvae feed on the roots of the cranberry plant, reducing yield as well as vine density. The female sex pheromone was identified as 2-tetradecanone. There were eight compounds found in the airborne volatiles collected from females that elicited antennal responses from males. Of the eight compounds tested (nonanal, decanal, dodecanal, 2-dodecanone, 2-tridecanone, 2-tetradecanone, 2-pentadecanone, and 2-hexadecanone), 2-tetradecanone was the only one that attracted male beetles in the field. Combining any of the other seven antennally active compounds with 2-tetradecanone did not increase male capture.