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81.
Differing cytotoxicity and bioavailability of selenite,methylselenocysteine, selenomethionine,selenosugar 1 and trimethylselenonium ion and their underlying metabolic transformations in human cells 下载免费PDF全文
82.
Sven Sängerlaub Doris Gibis Eva Kirchhoff Melanie Tittjung Markus Schmid Kajetan Müller 《Packaging Technology and Science》2013,26(1):17-30
To protect sensitive food products from oxidative deterioration, multilayer barrier film systems and also modified atmosphere packaging are widely applied. However, the preservation of food quality in such packaging systems may be compromised by the presence of defects in the sealing layer of the films, especially when these are below a critical size, typically the detection limit of standard leak testers of 10 µm. The addition of an oxygen scavenger (OS) layer in barrier film structures could therefore provide extended protection against O2 penetration through such defects. In this study, O2 absorption of different multilayer film structures including an iron‐based OS were investigated under defined gas atmospheres. Measurement cells were thereby covered with plastic films of defined O2 permeability to simulate conditions in a food package during storage with pinhole defect sizes of 10 and 17 µm. The results indicated that the OS film structures applied could only compensate for a defect size of 10 µm in the sealing layer. Analysis of the O2 absorption of different multilayer film structures at 85% and 100% relative humidity showed that higher humidity accelerates the activation of the scavenger. After full activation, the scavenger kinetics are the same for 85% and 100% relative humidity. Long‐term storage experiments using the most effective film structure from the preliminary experiments were carried out to compare O2 absorption of a snack food product in packages with and without an OS. The analyzed linear gradient of the reaction of the OS film and food product, respectively, indicated first‐order reaction kinetics with corresponding reaction constants calculated to be K (food product) 0.021 mg (O2) mbar (O2)?1 day?1 and K (OS film) 0.066 mg (O2) mbar (O2)?1 day?1. The reaction velocity of the OS was thus three times faster than that of the food. The applicability of OS multilayer film systems to compensate a critical pinhole defect size of 10 µm for sensitive food products could therefore be confirmed. The measurement of quality parameters for the status of lipid oxidation processes would help to verify this result. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
83.
Doris Lloyd Grosh 《技术计量学》2013,55(3):599-612
When sampling is carried out independently for the K strata of a finite stratified dichotomous population (defectives vs. standard items), and the number Zi of defectives per stratum sample is observed, the corresponding probability function for X = (Xi , …, xK ) is the product of hypergeometric functions which depend on the sample sizes ni , the stratum sizes Ni , and the number of defectives Mi in the stratum (i = 1, …, K). It is assumed that prior information is available about the Mi 's which can be expressed, by suitable choice of the parameters ai and bi , as the product of independent hyperbinomial functions. In each stratum the cost per observation is a known constant. Using squared error loss function, the prior Bayes risk is found for the linear function of interest, and the optimum allocation of sample sizes is found, the one for which the prior Bayes risk is minimum when the total sampling budget is fixed. 相似文献
84.
The histone deacetylases (HDACs) are able to regulate gene expression, and inhibitors of the HDACs (HDACIs) hold promise in the treatment of cancer as well as a variety of neurodegenerative diseases. To investigate the potential for isoform selectivity in the inhibition of HDACs, we prepared a small series of 2,4'-diaminobiphenyl ligands functionalized at the para-amino group with an appendage containing either a hydroxamate or a mercaptoacetamide group and coupled to an amino acid residue at the ortho-amino group. A smaller series of substituted phenylthiazoles was also explored. Some of these newly synthesized ligands show low-nanomolar potency in HDAC inhibition assays and display micromolar to low-nanomolar IC(50) values in tests against five pancreatic cancer cell lines. The isoform selectivity of these ligands for class I HDACs (HDAC1-3 and 8) and class IIb HDACs (HDAC6 and 10) together with QSAR studies of their correlation with lipophilicity are presented. Of particular interest is the selectivity of the mercaptoacetamides for HDAC6. 相似文献
85.
Polyphenolic grape seed extract (0.1 w/v%) was encapsulated in liposomes (1% soy lecithin) by high pressure homogenization at 22?500 psi. Liposomes containing grape extract had mean particle diameters of <100 nm compared to control liposomes that contained no extract and that had mean particle diameters of <40 nm. Liposomes with grape seed extract were long-term oxidatively stable, e.g. significantly less hexanal (<15 μmol L(-1)) was formed during storage for 150 days compared to liposomes without extract (>717 μmol L(-1)). Over 80% of the polyphenolic compounds in grape seed extract were incorporated into the liposomal membrane rather than into their interior and compounds remained integrated even if the system pH was changed. Coated liposomes were prepared by alternately adding a cationic polymer (chitosan) and an anionic polymer (citrus pectin). Up to 4 coats could be deposited onto the liposomes without incurring aggregation, i.e. dispersions were physically stable during storage for up to 150 days. Deposition of multiple biopolymer coats onto liposomes decreased the amount of polyphenols that reacted with the Folin-Ciocalteu reagent, suggesting that the polyphenols were no longer exposed to the aqueous phase. Our results hence indicate that polymer-coated liposomes are highly capable carrier systems for polyphenols that may have reduced interactions with ingredients in complex media such as foods. 相似文献
86.
The effect of plant sterols and different low doses of omega‐3 fatty acids from fish oil on lipoprotein subclasses 下载免费PDF全文
87.
Carbon nanotubes (CNTs) covalently modified with low molecular weight polyethylenimine (PEI) are able to bind and deliver siRNA to cells with higher efficacy than a reference lipidic carrier. The performances of the nanohybrid are rationalized by the combination of the cell penetration and endosomal escape properties of CNTs and PEI, respectively. 相似文献
88.
Heterocyclic amines (HAs) are formed as Maillard reaction products in the crust of meat products during heating processes. Two typical pizza toppings—salami and cooked ham—were analyzed for the presence of HAs after baking frozen pizzas at top and bottom temperatures of 250 and 230 °C, respectively. After baking pizza slices for 12 min, MeIQx (2‐amino‐3,4,8‐trimethylimidazo[4,5‐f]quinoxaline; 0.2 ng/g), 4,8‐DiMeIQx (2‐amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline; 0.5 ng/g), PhIP (2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine; 0.2 ng/g), norharman (4.5 ng/g), and harman (2.5 ng/g) were found in the ham toppings, whereas only the comutagenic norharman (107.4 ng/g) and harman (11.4 ng/g) were found in the salami toppings. The content of MeIQx and 4,8‐DiMeIQx in ham increased from 0.3 to 1.8 ng/g and 0.8 to 1.6 ng/g, respectively, when the recommended baking time was increased from 15 min (manufacturer's specification) to 18 min at 230 °C. MeIQx was formed in salami when the heating time was extended to 18 min. Moreover, higher concentrations of PhIP in salami or ham slices were found when baking temperatures were 250 °C rather than 230 °C (baking time of 12 min). However, sensory tests showed that panelists preferred longer‐baked pizzas due to an increased crispiness. Thus, results show that a substantial formation of HAs may occur in pizza toppings such as ham and salami, with ham being particularly susceptible when compared to salami. Formation of HAs increases with increasing baking time and temperature. The occurrence of the cupping of ham or salami slices during baking may also increase the formation of HAs. 相似文献
89.
90.
Kristina Klinkhammer Julia Bockelmann Chariklia Simitzis Gary A. Brook Dirk Grafahrend Jürgen Groll Martin Möller Jörg Mey Doris Klee 《Journal of materials science. Materials in medicine》2010,21(9):2637-2651
Microfibers produced with electrospinning have recently been used in tissue engineering. In the development of artificial
implants for nerve regeneration they are of particular interest as guidance structures for cell migration and axonal growth.
Using electrospinning we produced parallel-orientated biocompatible fibers in the submicron range consisting of poly(ε-caprolactone)
(PCL) and star shaped NCO-poly(ethylene glycol)-stat-poly(propylene glycol) (sPEG). Addition of the bioactive peptide sequence glycine-arginine-glycine-aspartate-serine (GRGDS)
or the extracellular matrix protein fibronectin to the electrospinning solution resulted in functionalized fibers. Surface
characteristics and biological properties of functionalized and non-functionalised fibers were investigated. Polymer solutions
and electrospinning process parameters were varied to obtain high quality orientated fibers. A polymer mixture containing
high molecular weight PCL, PCL-diol, and sPEG permitted a chemical reaction between hydroxyl groups of the diol and isocyanante
groups of the sPEG. Surface analysis demonstrated that sPEG at the fiber surface minimized protein adhesion. In vitro experiments
using dorsal root ganglia explants showed that the cell repellent property of pure PCL/sPEG fibers was overcome by functionalization
either with GRGDS peptide or fibronectin. In this way cell migration and axonal outgrowth along fibers were significantly
increased. Thus, functionalized electrospun PCL/sPEG fibers, while preventing non-specific protein adsorption, are a suitable
substrate for biological and medical applications. 相似文献