Towards an end-to-end airborne remote-sensing system for post-hazard assessment of damage to hyper-critical infrastructure: research progress and needs

The objective of this article is to synthesize research findings and requirements pertaining to development of time-sensitive remote-sensing systems (TSRSS) that support decision-making pertaining to post-hazard assessment of damage to what we define as hyper-critical infrastructure (HCI), based on an aerial imaging approach known as repeat station imaging (RSI). The following TSRSS components are addressed and related findings are reported: (1) understanding information requirements of emergency managers pertaining to damage of HCI; (2) flight planning and data capture requirements for supporting bi-temporal RSI pairs; (3) automatic image registration and shadow classification and normalization routines applied to RSI pairs; (4) damage detection and delineation approach that exploits simple temporal differences in image brightness to automatically, reliably, and robustly delineates new cracks associated with damage; and (5) rapid data and information transfer to emergency managers. The highest priority follow-on research topics are: (1) integrating small unmanned aerial systems (sUAS) with the RSI approach, while enabling multiple view perspectives other than vertical (i.e. nadir pointing) and (2) developing and testing of machine learning routines for automatic identification of damage features from RSI pairs, particularly those captured from integrated sUAS–RSI.     

The potential of subtype-selective neuronal nicotinic acetylcholine receptor agonists as therapeutic agents

Neuronal nicotinic acetylcholine receptors (NAChRs) are pentameric ligand-gated ion channel receptors which exist as different functional subunit combinations which apparently subserve different physiological functions as indicated by molecular biological and pharmacological techniques. It is possible to design and synthesize novel compounds that have greater selective affinities and efficacies than nicotine for different NAChRs, which should translate into different behavioral profiles and therapeutic potentials. Examples of NAChR agonists studied are nicotine, SIB-1508Y, SIB-1553A and epibatidine. These compounds have different degrees of selectivity for human recombinant NAChRs, different neurotransmitter release profiles in vitro and in vivo and differential behavioral profiles. Preclinical studies suggest that SIB-1508Y is a candidate for the treatment of the motor and cognitive deficits of Parkinson's disease, whereas SIB-1553A appears to have potential as a candidate for the treatment of Alzheimer's disease. Epibatidine has a strong analgesic profile, however the ratio between pharmacological activity and undesirable effects is so low that it is difficult to envisage the use of this compound therapeutically. Nicotine has a broad profile of pharmacological activity, for instance demonstrating activity in models for cognition and analgesia. As for epibatidine, the adverse effects of nicotine severely limits its therapeutic use in humans. The discovery of subtype-selective NAChR agonists such as SIB-1508Y and SIB-1553A provides a new class of neuropsychopharmacological agents with better therapeutic ratios than nonspecific agents such as nicotine.     

THE UPGRADING OF SOLVENT REFINED COALS AND LIGNITES: DETERMINATION OF AN EFFECTIVE HETEROGENOUS CATALYST CARRIER

The hydrodenitrogenation, hydrodesulfurization and hydrocracking of solvent refined coals and lignites was accomplished with catalysts comprising high surface area, large pore diameter bases impregnated with MoO₃,CoOand WO₃. The most effective catalysts were those which performed well in hydrodenitrogenating nitrocellulose. This indicates that most of the pore diameter is consistently large enough to accommodate molecules of the size of liquified coal and lignite.     

A new family of synthetic diterpenes that regulates cytokine synthesis by inhibiting IkappaBalpha phosphorylation

The synthesis and the biological evaluation of a new family diterpenes are presented. The synthetic studies were inspired by the structural framework of acanthoic acid (1) and yielded a family of compounds that were evaluated as anti-inflammatory agents. Among them, compounds 2, 10, 12, and 16 exhibited a very low nonspecific cytotoxicity and inhibited the synthesis of TNF-alpha with greater than 65 % efficacy at low micromolar concentrations. Cytokine-specificity studies revealed that these compounds also inhibited the synthesis of the proinflammatory cytokines IL-1beta and IL-6, while inhibition of IL-1ra and IL-8 synthesis was marginal and only occurred at high concentrations. Further studies, through EMSA and Western blot analyses, indicated that these compounds decreased the extent of phosphorylation of IkappaBalpha; this suggests that they exert their anti-inflammatory profile by inhibiting NF-kappaB-mediated cytokine synthesis. These findings imply that these diterpenes represent promising leads for the development of novel anti-inflammatory agents.     

Novel water sorption behavior of emulsion blends

As waterborne emulsions continue to replace their solvent‐based counterparts in various applications, the water resistance of cast films is attracting significant interest. The characterization of the water sorption kinetics and structure–property relationships related to water sorption is, therefore, an important area for investigation. In this study, the water sorption kinetics of emulsion blends were compared with those of their blend components. The investigated blends were at equal weight (dry basis) fractions for each emulsion. The initial water sorption rate for immiscible emulsion blends was found to be significantly higher than composite values of the constituents. This behavior was due to percolation networks in the blends because thermodynamic constraints prevented diffusion across the interface bordering dissimilar particles, leaving a interface enriched with water‐sensitive species. The peak water sorption for the immiscible emulsion blends was lower than the composite values because of the ability of the water‐sensitive species to rapidly diffuse out of the samples due to the percolation network. This behavior existed for room‐temperature‐cast samples and persisted as the time and temperature exposure was increased. Atomic force microscopy results clearly showed the potential for percolation networks in the blends. Higher glass‐transition emulsion polymers [e.g., poly(vinyl acetate)] exhibited similar behavior, and this indicated poor film formation like that for the immiscible emulsion blends. These results indicated that the degree of film formation was critical with respect to the water sorption characteristics of emulsion films. Immiscible emulsion blends were compared with miscible emulsion blends for which all constituents exhibited excellent film formation (unblended). The immiscible blends exhibited a significant difference in water sorption compared with the miscible blends because of the existence of percolation networks. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 90: 933–939, 2003     

Direct Measurement of Energy Barriers on Rough and Heterogeneous Solid Surfaces

The “three-liquid” contact angle approach to the surface free energy components of solids was applied to poly (vinyl fluoride), rough and flattened, with and without flame treatment. Lifshitz-van der Waals (LW), γ ^LW _SL , and acid-base (AB), γ ^LW _SL , components were determined and used to calculate ?δG _SL (W ^adhesion _SL ) for the formation of interfaces of five liquids with polymer. The automated goniometer allowed the determination of the energy barriers, ?δ G? _SL as the advancing liquid moved from pinned configuration to a metastable one. The acid-base component of the barriers was much greater than the LW, and the magnitude of the barriers was only slightly reduced by flattening.     

Group sequential testing in dental clinical trials with longitudinal data on multiple outcome variables

In this article, methods are proposed for design and analysis of clinical trials that gather longitudinal data on multiple outcome variables. A valid test of the null hypothesis of no treatment group differences can be obtained for any choice of a working alternative hypothesis and a working covariance matrix for the outcome variables. Increased power can be achieved by accurate modeling of the true treatment effect and covariance structure. Implementation of the procedure is simple using existing software for generalized estimating equations. The procedure is an extension of the 'derived variable' technique (univariate analysis applied to a linear combination of the outcome variables) and also of O'Brien's generalized least squares test. The procedure is extended to allow sequential testing using an arbitrary division of the total type I error rate among repeated hypothesis tests. The methods are illustrated by the design of a study on the safety of dental amalgam fillings, which served as the motivation for the research.     

Synthesis of Fluorinated Hyperbranched Polymers and Their Use as Additives in Cationic Photopolymerization

Summary: A fluorine containing hyperbranched polymer was synthesized by modifying an aromatic‐aliphatic hyperbranched polyester with a semifluorinated alcohol via a Mitsunobu reaction and was subsequently used as an additive in cationic photopolymerization of an epoxy resin. The remaining OH groups of the fluorinated hyperbranched polymer interact with the polymeric carbocation through a chain‐transfer mechanism inducing an increase in the final epoxy conversion. The fluorinated HBP induces modification of bulk and surface properties, with an increase in T_g and surface hydrophobicity already reached at very low concentration. The HBFP additive can, therefore, protect the coatings from aggressive solvents, increases hardness, and allows the preparation of a low energy surface coating.

Synthesis of fluorinated hyperbranched polyester.