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From the aspect of the development of a country, the energy sector represents a domain of strategic interest. Generation and use of energy resources most often belongs to the public sector, and are most often under the influence of the government in most countries. This paper analyzes the risks that are characteristic to the business of the public enterprise, Electric Power Industry of Serbia (EPS). EPS has started its restructuring and is adjusting to changes and challenges imposed by the launched reforms in the energy sector. However, due to certain limitations, it is still not possible to implement its complete restructuring and modernization. The paper aims to point at the risks a potential strategic partner faces. The risks have been identified as commercial, financial and political, classification immanent for project finance, and their evaluation was done using Failure Mode and Effects Analysis (FMEA). Risk analysis was performed based on current conditions for two potential scenarios that predict different types of changes in the analyzed period. The results of the analysis show that the potential strategic partner should pay special attention to price risks, estimation, investments, project activity neglect, quasi-risks and debt collection. 相似文献
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Dragana Stanic Jelena Radosavljevic Natalija Polovic Milka Jadranin Milica Popovic Olga Vuckovic Lidija Burazer Ratko Jankov Tanja Cirkovic Velickovic 《International Dairy Journal》2009,19(12):746-752
The use of enzymes may improve the functional properties of various food ingredients. The aim of this study was to examine the effects of proteolytic contaminants in phenol oxidases on β-lactoglobulin (BLG). In the presence of Trametes versicolor laccase and Agaricus bisporus tyrosinase, both variants of BLG (A and B) underwent removal of a peptide from the N-terminus. The truncated forms were more susceptible to digestion by pepsin. The truncation of BLG resulted from contaminating proteases and not due to the action of phenol oxidases. The removal of N-terminal peptides proceeded quickly, while the rest of the globular protein remained resistant to proteolysis for up to 3 h. In the case of the application of enzymes in food bioprocessing, it may be important to carefully monitor the effects of contaminating proteases in enzyme preparations used. 相似文献
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Lavond David G.; Kanzawa Sanae A.; Ivkovich Dragana; Clark Robert E. 《Canadian Metallurgical Quarterly》1994,108(2):284
Unilateral lesion of the cerebellum in rabbits completely and permanently abolishes previous learning and prevents new learning ipsilateral to the lesion. However, when training continues on the contralateral side, there is substantial savings in that it takes few trials to learn. This observation may imply that the memory survives the lesion. Rabbits were classically conditioned for an eyelid response and then the ipsilateral interpositus nucleus of the cerebellum was lesioned. Then the rabbits were trained on the contralateral side. There is no savings on the contralateral side without first trying to train on the lesioned side. It is concluded that the survival of a memory after the lesion probably does not account for the rapid transfer, but rather that the act of trying to train on the lesioned side in previous studies first induces a new memory on the contralateral side. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Six experiments are reported on perceiving the sizes of gaps by probing with a hand-held rod. A collective parameter, λ, is invariant over the time-varying dynamics of probing: λ?=?sin(α?)[1?–?(2a/b)?+?(a/p)]?=?sin(α?) δ, where α is the angular excursion of the rod-plus-limb segment and a, b, and p are distances, respectively, of the center of mass, point of contact, and the center of percussion from the axis of rotation. If perceived size is specific to λ, then it should (1) be a single-valued function of λ regardless of the muscles executing, and deformed by, the probing; (2) equal, underestimate, and overestimate actual size according to 2b/δ?=?1,2b/δ??1, respectively; and (3) change with actual size at a rate equal to (1/2b?–?a/b–2?+?a/2bp), the partial derivative of λ with respect to size. The experimentally confirmed predictions are discussed in relation to hypotheses about the specificity of perception to information, and the tensorial nature of dynamic touch. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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ana aranovi Zita ere Joki Aleksandar Biljana Pajin Ljubica Doki Julianna Gyura Boo Dalmacija Dragana oronja Simovi 《Starch - St?rke》2011,63(2):64-74
Wastewater obtained in the production process of wheat starch and vital wheat gluten was treated by microfiltration through a ceramic tubular membrane with 200 nm pore sizes. The consumption of process water would thus be reduced, the starch would be recovered to a greater extent and the wastewater problem would consequently be solved. Reduction of the occurrence of polarization layer on the membrane and the constant wastewater permeate flux through the membrane was maintained by inserting of the mixer Kenics inside the membrane tube. The maximum value of the permeate flux (24 L m−2 h−1) without the use of a static mixer was achieved at 3 × 10−5 Pa and at a flow rate of 150 L/h, for wastewater samples initially allowed to settle for 4 h prior microfiltration. Under the very same conditions of the working parameters, the use of a static mixer enables a flux that is up to two or three times more intensive compared to the values obtained without using a mixer. Microfiltration reduces the wastewater dry matter from 11 000 to 4000 mg/L, lessens the chemical oxygen demand by 74%, i.e. from 21 000 to 5100 mgO2/L and significantly decreases the values of the suspended matter, namely from 9000 to 300 mg/L. 相似文献
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Digestibility and allergenicity of β-lactoglobulin following laccase-mediated cross-linking in the presence of sour cherry phenolics 总被引:1,自引:0,他引:1
Ziyad Tantoush Dragana Stanic Marija Stojadinovic Jana Ognjenovic Luka Mihajlovic Marina Atanaskovic-Markovic Tanja Cirkovic Velickovic 《Food chemistry》2011
β-Lactoglobulin (BLG) is an important nutrient of dairy products, but it represents a serious health risk in patients allergic to milk. Sour cherry (Prunus cerasus L.) extract (SCE) is frequently added as a natural food colour in composite foods, such as fruit yogurt, ice creams, frappés and milkshakes. The aim of this study was to investigate the potential of laccase to cross-link BLG in the presence of an SCE and to characterise the obtained products for their bioactivity. 相似文献
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Matej Vizovisek Dragana Ristanovic Stefano Menghini Michael G. Christiansen Simone Schuerle 《International journal of molecular sciences》2021,22(5)
In recent decades, dysregulation of proteases and atypical proteolysis have become increasingly recognized as important hallmarks of cancer, driving community-wide efforts to explore the proteolytic landscape of oncologic disease. With more than 100 proteases currently associated with different aspects of cancer development and progression, there is a clear impetus to harness their potential in the context of oncology. Advances in the protease field have yielded technologies enabling sensitive protease detection in various settings, paving the way towards diagnostic profiling of disease-related protease activity patterns. Methods including activity-based probes and substrates, antibodies, and various nanosystems that generate reporter signals, i.e., for PET or MRI, after interaction with the target protease have shown potential for clinical translation. Nevertheless, these technologies are costly, not easily multiplexed, and require advanced imaging technologies. While the current clinical applications of protease-responsive technologies in oncologic settings are still limited, emerging technologies and protease sensors are poised to enable comprehensive exploration of the tumor proteolytic landscape as a diagnostic and therapeutic frontier. This review aims to give an overview of the most relevant classes of proteases as indicators for tumor diagnosis, current approaches to detect and monitor their activity in vivo, and associated therapeutic applications. 相似文献