Environmental factors promoting the effective use of a computer-assisted clinical case for second-year osteopathic medical students

We report a 38-year-old female of Puerto Rican descent with Hermansky-Pudlak syndrome and decreased levels of von Willebrand factor. Histologic and ultrastructural findings of non-sunexposed skin showed melanocytes with short dendritic processes and decreased numbers of melanosomes. Ultrastructural examination of platelets revealed greatly reduced numbers of delta granules. Recognition of this syndrome is important because skin neoplasms, ceroid deposition and hemorrhagic manifestations can be causes of morbidity and of potential death in patients affected with this syndrome.     

Isoelectric focusing of alkaline phosphatase isoenzymes in polyacrylamide gels. Use of Triton X-100 and improved staining technic

The examination of alkaline phosphatase isoenzymes by means of isoelectric focusing in polyacrylamide gel rods using the apparatus and focusing method of Righetti and Drysdale is discussed. A simultaneous coupling procedure using alpha-naphthyl phosphate and fast blue salt R in 2-amino-2-methyl-1,3-propanediol buffer, pH 9.68, containing MgCl2 and ZnSO4 proved sensitive for developing the enzyme bands. Also discussed are the effects seen with the incorporation of Triton X100 into the gel and sample mixtures. Enzyme, which remained at the top of the gel without using this detergent, entered the gel easily with the addition of Triton X-100 into the application solution. Incorporation of Triton into the gel matrix resulted in some enzyme band patterns that showed distinct differences from gels containing no Triton.     

Effect of isoessential fatty acid lipids from animal and plant sources on cholesterol levels in mature male rats

Isopolyunsaturated lipids isolated from plant and animal sources were included in the diets of mature male rats. Liver and blood serum cholesterol lowering effects were noted only in the lipid from the vegetable source. The authors suggest that the cholesterol lowering effect of vegetable oils is associated with the generally betaunsaturated triglycerides found therein. Journal Article No. 3758, Michigan Agricultural Experiment Station, East Lansing, Mich.     

Giant condyloma or Buschke-Loewenstein tumor

The Buschke-Loewenstein tumor has a malignant clinical character but is histologically similar to the ordinary condyloma. The tumor grows deeply without invading the tissues, but compresses them and causes an intense inflammatory reaction. The diagnosis is clinical. Treatment with podophyllin and radiotherapy are not effective but bleomycin may be effective. Surgery is the accepted treatment and the extent of resection depends on the extent of the tumor.     

Factors in sales success.

For the job of combination agent, an objective measure of job performance was correlated with each of 17 other variables in a sample of 346 agents, on whom were also obtained scores on a test of life insurance knowledge and data on life insurance ownership. "The data presented are consistent with the conclusion that the salesman's belief in his product (as measured by his own buying behavior) and his motivation are more important in determining how well he does his job than is product knowledge. Length of service shows no significant relation to job performance." (PsycINFO Database Record (c) 2010 APA, all rights reserved)