Telocytes’ Role in Modulating Gut Motility Function and Development: Medical Hypotheses and Literature Review

This review article explores the telocytes’ roles in inflammatory bowel diseases (IBD), presenting the mechanisms and hypotheses related to epithelial regeneration, progressive fibrosis, and dysmotility as a consequence of TCs’ reduced or absent number. Based on the presented mechanisms and hypotheses, we aim to provide a functional model to illustrate TCs’ possible roles in the normal and pathological functioning of the digestive tract. TCs are influenced by the compression of nearby blood vessels and the degree of fibrosis of the surrounding tissues and mediate these processes in response. The changes in intestinal tube vascularization induced by the movement of the food bowl, and the consequent pH changes that show an anisotropy in the thickness of the intestinal tube wall, have led to the identification of a pattern of intestinal tube development based on telocytes’ ability to communicate and modulate surrounding cell functions. In the construction of the theoretical model, given the predictable occurrence of colic in the infant, the two-layer arrangement of the nerve plexuses associated with the intestinal tube was considered to be incompletely adapted to the motility required with a diversified diet. There is resulting evidence of possible therapeutic targets for diseases associated with changes in local nerve tissue development.     

On a simplified system for steam production in nuclear power plants with pressurized water reactors

The paper develops the idea of a new system of steam production (Simplified System for Steam Production, SSSP) in nuclear power plants (NPPs) with PWR reactors, which is simplified as compared to the system used in the classical NPP of this type where steam is produced by steam generators (SGs). With the SSSP, expanders are used instead of SGs. The particularities of a NPP with a SSSP are analyzed in comparison to the classical NPP equipped with PWR and BWR reactors, which are used almost exclusively at present to produce electric energy at the industrial level.     

Improved Speech Synthesis Using Fuzzy Methods

The paper presents theoretical support for and describes the use of a fuzzy paradigm in implementing a TTS system for the Romanian language, employing a rule-based formant synthesizer. In the framework of classic TTS systems, we propose a new approach in order to improve formant trace computation, aiming at increasing synthetic speech perceptual quality. A fuzzy system is proposed for solving the problem of the phonemes that are prone to multi-definitions in rule-based speech synthesis. In the introductory section, we briefly present the background of the problem and our previous results in speech synthesis. In the second section, we deal with the problem of the context-dependent phonemes at the letter-to-sound module level of our TTS system. Then, we discuss the case of the phoneme /l/ and the solution adopted to define it for different contexts. A fuzzy system is associated with each parameter (denoted F1 and F2) to implement the results of the complete analysis of the phoneme /l/ behavior. The knowledge used in implementing the fuzzy module is acquired by natural speech analysis. In the third section, we exemplify the computation of the synthesis parameters F1 and F2 of the phoneme /l/ in the context of the two syllable sequences. The parameter values are contrasted with those obtained from the spectrogram analysis of the natural speech sequences. The last section presents the main conclusions and further research objectives.     

Thermal stress dependence of magnetic hysteretic processes in core–shell nanoparticles

The control of thermal stresses in the core–shell structures is an important task in order to understand their temperature dependent magnetization processes. This paper is dedicated to a theoretical and micromagnetic study of the thermal stresses on the hysteretic processes in core–shell nanoparticles. The analytical model can predict the thermal and elastic behavior of the core–shell nanoparticle supposed to a forced cooling process. The temperature and thermal stresses values obtained by direct computation from the analytical model were used to evaluate the magneto-elastic energy of the core–shell system. A micromagnetic model was used to compute the equilibrium positions of the particle magnetization as function of the applied field. The model allows an evaluation of the increase of the particle coercive field and of the blocking temperature as an effect of the thermal stress.     

Improved Nyquist filter characteristics using spline interpolation

This paper presents and investigates a novel approach for constructing a family of intersymbol interference (ISI)-free pulses that shows comparable or better ISI performance in the presence of sampling errors, compared with some recently proposed pulses. We propose and discuss a new parametric method for the design of Nyquist filter characteristics using constraints in frequency characteristics construction. The method for constructing the filter characteristics uses a piecewise polynomial approximation of an ideal optimized staircase characteristic by spline functions. The spline polynomials are used to approximate a function that must pass through specified points. The performances of new ISI-free pulses are studied with respect to the ISI error probability. This family provides flexibility in designing an appropriate pulse even after the roll-off factor has been chosen. The results for error probability outperform the fourth-degree polynomial pulse [4].     

Infectivity of Cryptosporidium parvum oocysts after storage of experimentally contaminated apples

Irrigation water and washing water have been inferred to be associated with contamination of fresh fruits and vegetables with pathogenic microorganisms infectious for humans. The objective of the present study was to determine whether apples experimentally contaminated with Cryptosporidium oocysts represent a food safety concern. Laser scanning confocal microscopy revealed no morphological changes in Cryptosporidium parvum oocysts attached to apples after 6 weeks of cold storage, suggesting that oocysts might remain viable and possibly infectious during prolonged storage. Mice were fed apple peels from experimentally contaminated apples to determine whether oocysts had remained infectious on apples stored for 4 weeks. All mice developed cryptosporidiosis. To evaluate the strength of oocyst attachment to apples, washing methods that have been reported to be helpful for recovery of oocysts from various foodstuffs were evaluated, except that the intensity of washing was increased in the present study. None of the tested washing methods succeeded in completely removing oocysts from the apple peel. The most efficient removal (37.5%) was achieved by rigorous manual washing in water with a detergent and by agitation in an orbital shaker with Tris-sodium dodecyl sulfate buffer. Glycine and phosphate-buffered saline buffers had no effect on oocyst removal. Scanning electron microscopy revealed that some oocysts were attached in deep natural crevices in the apple exocarp and others were attached to the smooth surface of the peel. Some oocysts were closely associated with what appeared to be an amorphous substance with which they might have been attached to the apple surface.     

Heat and mass transport impact on MHD second-grade fluid: A comparative analysis of fractional operators

The effect of the magnetic flux plays a major role in convective flow. The process of heat transfer is accompanied by a mass transfer process; for instance, condensation, evaporation, and chemical process. Due to the applications of the heat and mass transfer combined effects in different fields, the main aim of this paper is to do a comprehensive analysis of heat and mass transfer of magnetohydrodynamic (MHD) unsteady second-grade fluid in the presence of ramped conditions. The new governing equations of MHD second-grade fluid have been fractionalized by means of singular and nonsingular differentiable operators. To have an accurate physical significance of imposed conditions on the geometry of second-grade fluid, the constant concentration with ramped temperature and ramped velocity is considered. The fractional solutions of temperature, concentration, and velocity have been investigated by means of integral transform and inversion algorithm. The influence of physical parameters and flow is analyzed graphically via computational software (MATHCAD-15). The velocity profile decreases by increasing the Prandtl number. The existence of a Prandtl number may reflect the control of the thickness and enlargement of the thermal effect.