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11.
12.
The applicability of the phenomenological crystallographic theory to martensitic transformations in ferrous alloys is discussed, and it is concluded that only for the {3, 15, 10} F and {252} F transformations are experimental data sufficiently complete for detailed comparisons with predictions of the theory. Since crystallographic measurements have proved more difficult to obtain in the {252}F case a detailed assessment of electron microscopy observations and of reported measurements of the shape strain and orientation relationship is given for this transformation. The basic theory introduced, in the 1950's accounts satisfactorily for the {3, 15, 10} F transformation but not for the {252} F , case. Recent modifications of the theory based on multiple lattice invariant shears are also reviewed and are examined in the light of the crystallographic measurements. The use of experimental information to infer possible inhomogeneous deformation modes is emphasized. 相似文献
13.
Cytokine flow cytometry (CFC) is a multiparameter assay of antigen-specific T cell function, potentially useful in the monitoring of experimental vaccines and progression of infectious diseases and cancer. Automation of CFC assays would greatly facilitate their use in clinical trials and involves several components. We describe here the migration of these assays to 96-well plates, the use of sample-handling robotics, and the use of lyophilized antigen and antibody plates to help automate CFC. Together, these elements can produce an integrated system capable of walkaway automation of an entire assay, resulting in the reproducible processing of potentially hundreds of samples per day. Implementation of such systems has begun to be undertaken by our group and others. 相似文献
14.
F.P.E. Dunne A.M. Othman F.R. Hall D.R. Hayhurst 《International Journal of Mechanical Sciences》1990,32(11)
A methodology has been developed for the numerical determination of the material constants in the uniaxial creep constitutive equations based on continuum damage mechanics. The method developed overcomes former problems with convergence, and is based on a normalization technique. Temperature variation is included in the model.An algorithm for the digitization of continuous creep curves has been developed that enables a true representation of uniaxial creep behaviour using only 20 data points. Consequently large amounts of data covering many tests may therefore be stored in data bases, and, the method leads to short CPU times for fitting the material model.The algorithm for digitization and the constant determination methods have been applied to data for alloy 800H at 850°C; and, to
at 550°C. For both materials good comparisons have been obtained between experimental and predicted uniaxial creep behaviour. The material model has been shown to be suitable for large strain behaviour.Uniaxial creep tests have been carried out on grade 1 cast copper nominal composition 99.99% Cu, 0.005% O2, B.S. 1035–1037 at 150, 250 and 500°C, and an anisothermal continuum damage mechanics creep model developed for the temperature range 150–500°C. Model predictions are in good agreement with test results. 相似文献
15.
A table ofE - andH -plane patterns of the circular loop antenna withbeta b = 1.0 loaded withZ_{L} = R + jX atphi = 180deg is presented. The table gives useful information for determining the values of the load impedance for a given field pattern. The results were experimentally examined. 相似文献
16.
A literature review has shown that the chemical effects of grinding media on the flotation of real ores, especially those containing pyrite, are still not understood adequately. Many studies have been conducted on isolated minerals or in solutions only, and transport phenomena in the froth phase have generally been ignored in studies on galvanic interactions. A complex ore containing galena, sphalerite, chalcopyrite and significant quantities of magnetite, pyrrhotite and pyrite was used in batch flotation tests to study this problem. Metallic iron powder was added in different quantities to a ceramic ball mill in order to simulate the use of mild steel grinding media in flotation tests aimed at selectively floating chalcopyrite.An oxygen-saturated pulp milled in the presence of iron yielded the best recovery of chalcopyrite and copper-lead selectivity. Milling under a nitrogen atmosphere in the absence of metallic iron resulted in poor copper-lead selectivity. The galvanic interaction caused by the presence of iron yielded a stable, well-drained froth with low ratios of solids/water recovery and larger bubbles in the froth. However, milling in the absence of iron caused an extremely brittle froth with very fine bu bubbles, high recoveries of low grades of sulphur. In contrast with the improvement in the copper recovery and copper-lead selectivity obtained when the pulp was pre-aerated after milling in the presence of iron, no significant increase in the copper grade was observed after extensive pre-aeration when milling occurred in the absence of iron. The unsatisfactory flotation results in the absence of iron could be explained by the enhanced floatability of iron-bearing gangue minerals, which rupture films and suppress froth stability owing to bubble-overloading. 相似文献
17.
Adrian Dunne 《Computer methods and programs in biomedicine》1985,20(3):269-275
A new iterative polyexponential curve stripping technique for the provision of initial pharmacokinetic parameter estimates has been developed. Such estimates are required for nonlinear least-squares curve fitting. In contrast to conventional curve stripping, this new technique does not make any assumption about the relative magnitudes of the exponential rate constants. Hence, the parameter estimates which it provides are free of the bias which may arise in conventional curve stripping. A BASIC program called JANA has been developed to implement the new curve stripping procedure. 相似文献
18.
Paul E. Dunne 《Acta Informatica》1985,22(2):229-240
Summary The k-th threshold function, T
k
n
, is defined as:
where x
i{0,1} and the summation is arithmetic. We prove that any monotone network computing T
3/n(x
1,...,x
n) contains at least 2.5n-5.5 gates.This research was supported by the Science and Engineering Research Council of Great Britain, UK 相似文献
19.
Le Zhao Christine E. Dunne Dane J. Clausen Justin M. Roberts Joshiawa Paulk Haining Liu Olaf G. Wiest James E. Bradner Robert M. Williams 《Israel journal of chemistry》2017,57(3-4):319-330
The synthesis of biotinylated conjugates of synthetic analogues of the potent and selective histone deacetylase (HDAC) inhibitor largazole is reported. The thiazole moiety of the parent compound's cap group was derivatized to allow the chemical conjugation to biotin. The derivatized largazole analogues were assayed across a panel of HDACs 1–9 and retained potent and selective inhibitory activity towards the class I HDAC isoforms. The biotinylated conjugate was further shown to pull down HDACs 1, 2, and 3. 相似文献
20.
Nina Dunne 《Hemodialysis international. International Symposium on Home Hemodialysis》2017,21(3):312-322
Introduction Hemodialysis has improved in recent years, however, despite such improvements, intra‐dialytic hypotensive episodes still persist which can lead to a reduction in the overall effectiveness of the treatment. Profiling sodium levels during dialysis can improve vascular refilling and therefore may prevent hypotensive events. A number of profiling methods exist and this meta‐analysis set out to examine the effectiveness of these methods. Methods To assess the effectiveness of hemodialysis sodium profiling techniques. A review and meta‐analysis analytical framework was used. A search was conducted using Medline, Embase and CINAHL, Scopus and Web of Knowledge between 1946 and 2014 of published English‐language peer reviewed randomized control studies. In total 10 articles were retrieved and included in the review. All data was abstracted with a standardized data collection form. Stata 11.2 (Stata Corp) was used to analyse the data. Actual numbers of hypotensive events were pooled between studies. Analysis of subgroups was performed on sodium profile type. The data were further investigated using meta‐regression. Publication bias was also tested. Findings Stepwise profiling was shown to be statistically significantly effective in reducing intradialytic episodes. Results demonstrated that linear sodium profiling was not effective in reducing hypotensive events during dialysis. Discussion This review has shown that using stepwise profiling is more effective at reducing intra‐dialytic symptoms than other profiling methods. There was no evidence that linear profiling method was any more effective than conventional dialysis and in fact the results showed the reverse. 相似文献