Robust control via concave minimization local and global algorithms

This paper is concerned with the robust control problem of linear fractional representation (LFT) uncertain systems depending on a time-varying parameter uncertainty. Our main result exploits a linear matrix inequality (LMI) characterization involving scalings and Lyapunov variables subject to an additional essentially nonconvex algebraic constraint. The nonconvexity enters the problem in the form of a rank deficiency condition or matrix inverse relation on the scalings only. It is shown that such problems, but also more generally rank inequalities and bilinear constraints, can be formulated as the minimization of a concave functional subject to LMI constraints. First of all, a local Frank and Wolfe (1956) feasible direction algorithm is introduced in this context to tackle this hard optimization problem. Exploiting the attractive concavity structure of the problem, several efficient global concave programming methods are then introduced and combined with the local feasible direction method to secure and certify global optimality of the solutions. Computational experiments indicate the viability of our algorithms, and in the worst case, they require the solution of a few LMI programs     

Diagnosis and treatment of aortic valve stenosis

The present review has attempted to summarize the classic symptoms and signs of aortic valve stenosis, especially in an adult. It is emphasized that all the classic signs rarely are present and their absence may mislead an unwary clinician. The diagnostic help provided by noninvasive tests, including echocardiography and phonocardiography, has been emphasized. A need for cardiac catheterization and angiography in most patients prior to corrective surgery is stressed. The natural history of the disease without operative intervention is dim and a significant risk of sudden death exists. The current surgical approach with immediate and long-term results is summarized. Finally, attention has been drawn to the special clinical circumstances when the aortic valve stenosis provides a strinkingly different clinical picture. We cannot find a better way to end this review than by quoting a warning note given by Thomas Lewis in 1920: "It is the faint cry of an anguished and fast failing muscle, which, when it comes, all should strain to hear, for it is not long repeated. A few months, a few years at most, and the end comes."     

Low temperature synthesis and characterisation of lecontite, (NH4)Na(SO4)·2H20

Lecontite, (NH₄)Na(SO₄).2H₂O, was synthesised at room temperature in high purity compared to earlier work with a minor impurity of mascagnite, (NH₄)₂SO₄. Rietveld refinement of the XRD results confirmed the crystal structure and unit cell dimensions as published earlier. Raman and Infrared spectroscopy, in conjunction with factor group analysis, resulted in a complex pattern of overlapping sulphate, NH and OH modes. The NH modes υ₁ was observed around 2880 cm⁻¹, υ₂ around 1700 cm⁻¹ overlapping with water OH-bending modes, υ₃ around 3300 cm⁻¹ overlapping with water OH-stretching modes around 3023, 3185 and 3422 cm⁻¹, and υ₄ around 1432, 1447 and 1462 cm⁻¹. The sulphate group in the crystal structure displays a decrease in symmetry from T_d as evidenced by the activation of the ν₁ mode at 982 cm⁻¹ and the ν₂ mode around 452 cm⁻¹ in the Infrared spectrum. The υ₃ mode shows clear splitting in the infrared spectra with a strong band at 1064 cm⁻¹ accompanied by two shoulders at 1107 and 1139 cm⁻¹. The Raman spectra show three weak bands at 1068, 1109 and 1135 cm⁻¹ with a shoulder at 1155 cm⁻¹. Similar splitting was observed for the υ₄ mode around 611 and 632 cm⁻¹ in the Infrared and Raman spectra, respectively.     

Immunology and adjuvant chemoimmunotherapy of breast cancer

Antibody against a breast carcinoma antigen was present in patients with breast carcinoma and other cancer more often (P less than .05) than in normal women. The incidence of antibody in women with breast carcinoma correlated with the presence or absence of gross tumor, and the titer of antibody paralleled the clinical course. These results suggest importance of a host-immune response to breast carcinoma. Fifty-seven patients with stage II carcinoma of the breast were entered into a prospective randomized adjuvant chemoimmunotherapy program of cyclophosphamide, methotrexate, and fluorouracil, and BCG vaccine +/- an irradiated allogeneic tumor cell vaccine. After 24 months of study, metastases occurred in two patients (3.5%) and a new primary carcinoma developed in the contralateral breast in two others, for an overall treatment failure rate of 7%. Adjuvant chemoimmunotherapy can delay early recurrence. Long-term follow-up is needed to assess the significance of these results.     

Unilateral Cervical Vagotomy Modulates Immune Cell Profiles and the Response to a Traumatic Brain Injury

TBI induces splenic B and T cell expansion that contributes to neuroinflammation and neurodegeneration. The vagus nerve, the longest of the cranial nerves, is the predominant parasympathetic pathway allowing the central nervous system (CNS) control over peripheral organs, including regulation of inflammatory responses. One way this is accomplished is by vagus innervation of the celiac ganglion, from which the splenic nerve innervates the spleen. This splenic innervation enables modulation of the splenic immune response, including splenocyte selection, activation, and downstream signaling. Considering that the left and right vagus nerves have distinct courses, it is possible that they differentially influence the splenic immune response following a CNS injury. To test this possibility, immune cell subsets were profiled and quantified following either a left or a right unilateral vagotomy. Both unilateral vagotomies caused similar effects with respect to the percentage of B cells and in the decreased percentage of macrophages and T cells following vagotomy. We next tested the hypothesis that a left unilateral vagotomy would modulate the splenic immune response to a traumatic brain injury (TBI). Mice received a left cervical vagotomy or a sham vagotomy 3 days prior to a fluid percussion injury (FPI), a well-characterized mouse model of TBI that consistently elicits an immune and neuroimmune response. Flow cytometric analysis showed that vagotomy prior to FPI resulted in fewer CLIP+ B cells, and CD4+, CD25+, and CD8+ T cells. Vagotomy followed by FPI also resulted in an altered distribution of CD11b^high and CD11b^low macrophages. Thus, transduction of immune signals from the CNS to the periphery via the vagus nerve can be targeted to modulate the immune response following TBI.     

Modified Fluoroquinolones as Antimicrobial Compounds Targeting Chlamydia trachomatis

Chlamydia trachomatis causes the most common sexually transmitted bacterial infection and trachoma, an eye infection. Untreated infections can lead to sequelae, such as infertility and ectopic pregnancy in women and blindness. We previously enhanced the antichlamydial activity of the fluoroquinolone ciprofloxacin by grafting a metal chelating moiety onto it. In the present study, we pursued this pharmacomodulation and obtained nanomolar active molecules (EC₅₀) against this pathogen. This gain in activity prompted us to evaluate the antibacterial activity of this family of molecules against other pathogenic bacteria, such as Neisseria gonorrhoeae and bacteria from the ESKAPE group. The results show that the novel molecules have selectively improved activity against C. trachomatis and demonstrate how the antichlamydial effect of fluoroquinolones can be enhanced.     

Multiple human tracking in drone image

Multimedia Tools and Applications - Object tracking, especially human tracking is one of the challenging research problems in computer vision. Although the performance has gained some positive...