Closing the digital divide: understanding racial, ethnic, social class, gender and geographic disparities in Internet use among school age children in the United States

The purpose of this study is to explore the dynamics underlying disparities in Internet use among school age children in the US. The analysis found that a broad range of demographic, geographic and economic factors significantly influence Internet use among children. Significantly, the availability of household computing resources and adult Internet users in the household were most important in explaining disparities in use among children. To expand universal Internet access, future public policy should focus on providing support for in-home access; continued support for public access at out-of-home locations such as schools, and providing technical support, training and expertise to school age children.

A comparative analysis of video codecs for multihop wireless video sensor networks

Wireless video sensor networks (WVSNs) have drawn significant attention in recent years due to the advent of low-cost miniaturized cameras, which makes it feasible to realize large-scale WVSNs for a variety of applications including security surveillance, environmental tracking, and health monitoring. However, the conventional video coding paradigms are not suitable for WVSNs due to resource constraints such as limited computation power, battery energy, and network bandwidth. In this paper, we evaluated and analyzed the performance of video codecs based on emerging video coding paradigms such as distributed video coding and distributed compressive video sensing for multihop WVSNs. The main objective of this work was to provide an insight into the computational (encoding/decoding) complexity, energy consumption, node and network lifetime, processing and memory requirements, and the quality of reconstruction of these video codecs. Based on the findings, this paper also provides some guidelines for the selection of appropriate video codecs for a given WVSN application.     

Revealing performance heterogeneity through knowledge management maturity evaluation: A capability-based approach

The dynamic capabilities view (DCV) focuses on renewal of firms’ strategic knowledge resources so as to sustain competitive advantage within turbulent markets. Within the context of the DCV, the focus of knowledge management (KM) is to develop the KMC through deploying knowledge governance mechanisms that are conducive to facilitating knowledge processes so as to produce superior business performance over time. The essence of KM performance evaluation is to assess how well the KMC is configured with knowledge governance mechanisms and processes that enable a firm to achieve superior performance through matching its knowledge base with market needs. However, little research has been undertaken to evaluate KM performance from the DCV perspective. This study employed a survey study design and adopted hypothesis-testing approaches to develop a capability-based KM evaluation framework (CKMEF) that upholds the basic assertions of the DCV. Under the governance of the framework, a KM index (KMI) and a KM maturity model (KMMM) were derived not only to indicate the extent to which a firm’s KM implementations fulfill its strategic objectives, and to identify the evolutionary phase of its KMC, but also to bench-mark the KMC in the research population. The research design ensured that the evaluation framework and instruments have statistical significance and good generalizabilty to be applied in the research population, namely construction firms operating in the dynamic Hong Kong construction market. The study demonstrated the feasibility of quantitatively evaluating the development of the KMC and revealing the performance heterogeneity associated with the development.     

A study on the rate of degradation of the bioabsorbable polymer polyglycolic acid (PGA)

As part of a study to characterise bioabsorbable scaffolds for tissue engineering an investigation has been conducted into the rate of degradation of polyglycolic acid (PGA). This is one of the most commonly used bioabsorbable materials and has been used in sutures since the 60s and more recently in cell scaffolds, drug delivery devices and bone fixation pins. This study looks at the influence that surface-to-volume ratio i.e. thickness of material, has on degradation. By degrading various thicknesses of PGA in a buffer saline solution over 24 days and testing their properties at regular intervals, a knowledge of how surface-to-volume ratio affects degradation was developed. Properties such as weight loss, crystallinity, molecular weight and structural integrity were measured. Results showed that rate of mass loss was dependent on sample thickness but crystallinity, melting point and molecular weight were independent of thickness.     

Efficient encoding of quasi-cyclic low-density parity-check codes

Quasi-cyclic (QC) low-density parity-check (LDPC) codes form an important subclass of LDPC codes. These codes have encoding advantage over other types of LDPC codes. This paper addresses the issue of efficient encoding of QC-LDPC codes. Two methods are presented to find the generator matrices of QC-LDPC codes in systematic-circulant (SC) form from their parity-check matrices, given in circulant form. Based on the SC form of the generator matrix of a QC-LDPC code, various types of encoding circuits using simple shift registers are devised. It is shown that the encoding complexity of a QC-LDPC code is linearly proportional to the number of parity bits of the code for serial encoding, and to the length of the code for high-speed parallel encoding.     

电动旋转定位机设计与分析

介绍一种旋转定位机的工作原理，分析了定位机的分度精度和传动力矩计算，建立了完整的设计准则，为定位机的正确使用和设计开发提供了理论根据．     

Combining interaction and context design to support collaborative argumentation using a tool for synchronous CMC

Abstract Empirical studies and theory suggest that educational dialogue can be used to support learners in the development of reasoning, critical thinking and argumentation. This paper presents an educational design for synchronous online peer discussion that guides student dialogue in ways that lead to improved argumentation and collaborative knowledge development. This design includes a mediating interface – or tool, linked to a broader set of online educational activities – a designed local context, where the latter aims to provide conditions that support argumentation. The approach is based on collaborative working and dialogue game approaches to discussion. Preliminary findings with UK Open University students showed the argumentation process was more coherent, varied, deeper and extended when using our interaction design compared with the use of a simple unstructured interface.     

Enhanced and Differential Capture of Circulating Tumor Cells from Lung Cancer Patients by Microfluidic Assays Using Aptamer Cocktail

Collecting circulating tumor cells (CTCs) shed from solid tumor through a minimally invasive approach provides an opportunity to solve a long‐standing oncology problem, the real‐time monitoring of tumor state and analysis of tumor heterogeneity. However, efficient capture and detection of CTCs with diverse phenotypes is still challenging. In this work, a microfluidic assay is developed using the rationally‐designed aptamer cocktails with synergistic effect. Enhanced and differential capture of CTCs for nonsmall cell lung cancer (NSCLC) patients is achieved. It is also demonstrated that the overall consideration of CTC counts obtained by multiple aptamer combinations can provide more comprehensive information in treatment monitoring.     

Proteomic Biomarkers of the Apnea Hypopnea Index and Obstructive Sleep Apnea: Insights into the Pathophysiology of Presence,Severity, and Treatment Response

Obstructive sleep apnea (OSA), a disease associated with excessive sleepiness and increased cardiovascular risk, affects an estimated 1 billion people worldwide. The present study examined proteomic biomarkers indicative of presence, severity, and treatment response in OSA. Participants (n = 1391) of the Stanford Technology Analytics and Genomics in Sleep study had blood collected and completed an overnight polysomnography for scoring the apnea–hypopnea index (AHI). A highly multiplexed aptamer-based array (SomaScan) was used to quantify 5000 proteins in all plasma samples. Two separate intervention-based cohorts with sleep apnea (n = 41) provided samples pre- and post-continuous/positive airway pressure (CPAP/PAP). Multivariate analyses identified 84 proteins (47 positively, 37 negatively) associated with AHI after correction for multiple testing. Of the top 15 features from a machine learning classifier for AHI ≥ 15 vs. AHI < 15 (Area Under the Curve (AUC) = 0.74), 8 were significant markers of both AHI and OSA from multivariate analyses. Exploration of pre- and post-intervention analysis identified 5 of the 84 proteins to be significantly decreased following CPAP/PAP treatment, with pathways involving endothelial function, blood coagulation, and inflammatory response. The present study identified PAI-1, tPA, and sE-Selectin as key biomarkers and suggests that endothelial dysfunction and increased coagulopathy are important consequences of OSA, which may explain the association with cardiovascular disease and stroke.