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The operation of ion implanted silicon position sensitive detectors at low temperatures will be described. The improved noise performance of the detector at these temperatures in both the energy and position modes will be analyzed and its implications on low energy applications will be discussed. A large part of the investigation was devoted to the study of boron implanted resistors and their noise properties both at room temperature and cryogenic temperatures. 相似文献
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Two are Better than One: Combining ZnO and MgF2 Nanoparticles Reduces Streptococcus pneumoniae and Staphylococcus aureus Biofilm Formation on Cochlear Implants
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Michal Natan Fredrik Edin Nina Perkas Gila Yacobi Ilana Perelshtein Elad Segal Alexandra Homsy Edith Laux Herbert Keppner Helge Rask‐Andersen Aharon Gedanken Ehud Banin 《Advanced functional materials》2016,26(15):2473-2481
Streptococcus pneumoniae (S. pneumoniae) and Staphylococcus aureus (S.aureus) are considered the most common colonizers of cochlear implants (CI), which have prompted the search for new ways to inhibit their growth and biofilm development. In the current study, CI‐based platforms are prepared and sonochemically coated with ZnO or MgF2 nanoparticles (NPs), two agents previously shown to possess antibacterial properties. Additionally, a method is developed for coating both ZnO and MgF2 on the same platform to achieve synergistic activity against both pathogens. Each surface is characterized, and the optimal conditions for the NP homogenous distribution on the surface are determined. The ZnO‐MgF2 surface significantly reduces the S. pneumoniae and S. aureus biofilm compared with the surfaces coated with either ZnO or MgF2, even though it contains smaller amounts of each NP type. Importantly, leaching assays show that the NPs remain anchored to the surface for at least 7 d. Finally, biocompatibility studies demonstrate that coating with low concentrations of ZnO‐MgF2 results in no toxicity toward primary human fibroblasts from the auditory canal. Taken together, these findings underscore the potential of using NP combinations such as the one presented here to efficiently inhibit bacterial colonization and growth on medical devices such as CIs. 相似文献
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The catalytic reactivity and selectivity of metallic nanoclusters supported on a metal-oxide can be tuned by electronic charge. In this review, different approaches for controlling the electronic properties of metallic nanoclusters and its impact on catalytic reactions are discussed. Electronic charge can transfer from the metal-oxide support to the metallic catalyst and change the metal–reactants interaction and as a consequence modify as-well the catalytic reactivity and selectivity. In other cases, the electronic properties of the metal-oxide have an active role in the catalytic process and the metal oxide can be used as a co-catalyst. Another approach is to directly change the electronic properties of the metallic catalyst. It is demonstrated that dendrimer-encapsulated metallic nanoparticles can be directly oxidized by the addition of an inorganic oxidizer to the solution phase. In this case, even while supported on inert oxides, novel catalytic reactivity and selectivity can be gained by the formation of highly oxidized metal ions. 相似文献
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Perlman David M.; Salomons Tim V.; Davidson Richard J.; Lutz Antoine 《Canadian Metallurgical Quarterly》2010,10(1):65
Pain is an unpleasant sensory and emotional experience that can be regulated by many different cognitive mechanisms. We compared the regulatory qualities of two different meditation practices during noxious thermal stimuli: Focused Attention, directed at a fixation cross away from the stimulation, which could regulate negative affect through a sensory gating mechanism; and Open Monitoring, which could regulate negative affect through a mechanism of nonjudgmental, nonreactive awareness of sensory experience. Here, we report behavioral data from a comparison between novice and long-term meditation practitioners (long-term meditators, LTMs) using these techniques. LTMs, compared to novices, had a significant reduction of self-reported unpleasantness, but not intensity, of painful stimuli while practicing Open Monitoring. No significant effects were found for FA. This finding illuminates the possible regulatory mechanism of meditation-based clinical interventions like Mindfulness-Based Stress Reduction (MBSR). Implications are discussed in the broader context of training-induced changes in trait emotion regulation. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Super-resolution reconstruction of image sequences 总被引:17,自引:0,他引:17
In an earlier work (1999), we introduced the problem of reconstructing a super-resolution image sequence from a given low resolution sequence. We proposed two iterative algorithms, the R-SD and the R-LMS, to generate the desired image sequence. These algorithms assume the knowledge of the blur, the down-sampling, the sequences motion, and the measurements noise characteristics, and apply a sequential reconstruction process. It has been shown that the computational complexity of these two algorithms makes both of them practically applicable. In this paper, we rederive these algorithms as approximations of the Kalman filter and then carry out a thorough analysis of their performance. For each algorithm, we calculate a bound on its deviation from the Kalman filter performance. We also show that the propagated information matrix within the R-SD algorithm remains sparse in time, thus ensuring the applicability of this algorithm. To support these analytical results we present some computer simulations on synthetic sequences, which also show the computational feasibility of these algorithms 相似文献
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This paper presents a new method based on adaptive filtering theory for superresolution restoration of continuous image sequences. The proposed methodology suggests least squares (LS) estimators which adapt in time, based on adaptive filters, least mean squares (LMS) or recursive least squares (RLS). The adaptation enables the treatment of linear space and time-variant blurring and arbitrary motion, both of them assumed known. The proposed new approach is shown to be of relatively low computational requirements. Simulations demonstrating the superresolution restoration algorithms are presented. 相似文献
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Elad Ben-Cnaan Anna Permyakova Shahar Azar Shira Hirsch Saja Baraghithy Liad Hinden Joseph Tam 《International journal of molecular sciences》2022,23(10)
Obesity is a global medical problem; its common form is known as diet-induced obesity (DIO); however, there are several rare genetic disorders, such as Prader–Willi syndrome (PWS), that are also associated with obesity (genetic-induced obesity, GIO). The currently available therapeutics for treating DIO and GIO are very limited, and they result in only a partial improvement. Cannabidiolic acid (CBDA), a constituent of Cannabis sativa, gradually decarboxylates to cannabidiol (CBD). Whereas the anti-obesity properties of CBD have been reasonably identified, our knowledge of the pharmacology of CBDA is more limited due to its instability. To stabilize CBDA, a new derivative, CBDA-O-methyl ester (HU-580, EPM301), was synthesized. The therapeutic potential of EPM301 in appetite reduction, weight loss, and metabolic improvements in DIO and GIO was tested in vivo. EPM301 (40 mg/kg/d, i.p.) successfully resulted in weight loss, increased ambulation, as well as improved glycemic and lipid profiles in DIO mice. Additionally, EPM301 ameliorated DIO-induced hepatic dysfunction and steatosis. Importantly, EPM301 (20 and 40 mg/kg/d, i.p.) effectively reduced body weight and hyperphagia in a high-fat diet-fed Magel2null mouse model for PWS. In addition, when given to standard-diet-fed Magel2null mice as a preventive treatment, EPM301 completely inhibited weight gain and adiposity. Lastly, EPM301 increased the oxidation of different nutrients in each strain. All together, EPM301 ameliorated obesity and its metabolic abnormalities in both DIO and GIO. These results support the idea to further promote this synthetic CBDA derivative toward clinical evaluation in humans. 相似文献