Quadruped Gait and Regulation of Apoptotic Factors in Tibiofemoral Joints following Intra-Articular rhPRG4 Injection in Prg4 Null Mice

Camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome leads to diarthrodial joint arthropathy and is caused by the absence of lubricin (proteoglycan 4—PRG4), a surface-active mucinous glycoprotein responsible for lubricating articular cartilage. In this study, mice lacking the orthologous gene Prg4 served as a model that recapitulates the destructive arthrosis that involves biofouling of cartilage by serum proteins in lieu of Prg4. This study hypothesized that Prg4-deficient mice would demonstrate a quadruped gait change and decreased markers of mitochondrial dyscrasia, following intra-articular injection of both hindlimbs with recombinant human PRG4 (rhPRG4). Prg4^−/− (N = 44) mice of both sexes were injected with rhPRG4 and gait alterations were studied at post-injection day 3 and 6, before joints were harvested for immunohistochemistry for caspase-3 activation. Increased stance and propulsion was shown at 3 days post-injection in male mice. There were significantly fewer caspase-3-positive chondrocytes in tibiofemoral cartilage from rhPRG4-injected mice. The mitochondrial gene Mt-tn, and myosin heavy (Myh7) and light chains (Myl2 and Myl3), known to play a cytoskeletal stabilizing role, were significantly upregulated in both sexes (RNA-Seq) following IA rhPRG4. Chondrocyte mitochondrial dyscrasias attributable to the arthrosis in CACP may be mitigated by IA rhPRG4. In a supporting in vitro crystal microbalance experiment, molecular fouling by albumin did not block the surface activity of rhPRG4.     

An Efficient Image Steganography Approach over Wireless Communication System

Wireless Personal Communications - This paper presents a robust color image steganography approach for image communication over wireless communication systems. The objective of this approach is to...     

Computer model and charge transport studies in short gate charge-coupled devices

A computer model has been developed that simulates charge transport of carriers in a surface channel charge-coupled device. This model is based on the charge continuity and current transport equations with a time dependent surface field. The device structure of the model includes a source diffusion an input gate and transfer gate. The present model is the first real simulation of the input scheme of the surface-channel CCDs. The scooping and spilling techniques associated with the charge injection process are simulated by the input diffusion which is included in the model.As an application to a CCD practical problem the present model has been used to study the linearity of the electrical charge injection into surface channel charge-coupled devices. The generated harmonic components of a sinusoidal input are calculated using the transfer characteristics of the input stage obtained from the computer simulation.Using this model the spatial variations of the self-induced fringing field and total currents under the storage and transfer gates were computed. The charge transfer mechanisms for short-gate (L ≤ 8 μm) CCDs was investigated. It was found that for short gates the charge transfer efficiency is governed mainly by the fringing field and self-induced current mechanisms. The results of this study help to clarify the mechanism by which the signal-charge level and gate length affect the charge transfer efficiency.     

Rhodamine-B modified silica for uranium(VI) extraction from aqueous waste samples

Silica modified with rhodamine-B has been synthesized, characterized and used for solid phase extraction (SPE) of uranium(VI) (U(VI)) from aqueous waste solutions. Adsorption efficiency was influenced by various parameters, which have been investigated such as solution pH, shaking time, initial concentration, adsorbent dose and possible competing ions. The study showed that uranium adsorption was found to be quantitative at pH 5. The adsorption percentage of U(VI) was found to be 94% at the optimum conditions. Desorption conditions were also examined. About 99% of uranium loaded on modified silica was desorbed by 6% of HCl. The method was applicable for removal of uranium from natural samples.     

Transition metal carbides and nitrides as oxygen reduction reaction catalyst or catalyst support in proton exchange membrane fuel cells (PEMFCs)

Fuel cells are potentially efficient, silent, and environmentally friendly tools for electrical power generation. One of the obstacles facing the development and the commercialization of fuel cells is the dependence on the precious metal catalyst, i.e., Platinum (Pt) and Pt - alloy, especially at the cathode where high catalyst loading used to compensate the sluggish oxygen reduction reaction (ORR). Pt is not only an expensive and rare element but also has insufficient durability. The development of an efficient non-precious catalyst, i.e., electrochemically active, chemically and mechanically stable, and electrically conductive, is one of the basic requirements for the commercialization of fuel cells. The bonding to carbon and nitrogen to form metal carbides and nitrides modify the nature of the d-band of the parent metal, thus improve its catalytic properties relative to the parent metals to be similar to those of group VIII noble metals. In this article, we summarize the progress in the development of the transition metal carbides (TMCs) and transition metals nitrides (TMNs) relative to their application as catalysts for the ORR in fuel cells. The preparation of TMCs and TMNs via different routes which significantly affects its activity is discussed. The ORR catalytic activity of the TMCs and TMNs as a non-precious catalyst or catalyst support in fuel cells is discussed and compared to that of the Pt-based catalyst in this review article. Moreover, the recent progress in the preparation of the nano-sized (which is a critical factor for increasing the activity at low temperature) TMCs and TMNs are discussed.     

Voltage profile enhancement by fuzzy controlled MLI UPFC

A fuzzy logic controlled multi-level inverter based unified power flow controller system is used in a transmission line to maintain voltage profile and protect/compensate against over-voltages, under-voltages, sags and swells. The controller is designed as a stand-alone module and tested in PSCAD-EMTDC environment. The results show that the controller is robust and can rapidly maintain voltage stability under different load conditions.