On-column solvent exchange for purified preparative fractions

On-column solvent exchange, using many of the principles of solid-phase extraction, has been implemented to significantly reduce evaporation cycle time following reverse-phase preparative HPLC. Additional benefits, such as a reduced potential for salt formation, thermal decomposition, and residual solvent, are also described. Fractions obtained from preparative separations, typically in a large volume of acetonitrile:water, are injected into the preparative HPLC and then eluted in acetonitrile, creating a new fraction in a volatile organic solvent. Minimal modification to the instrument was required, and unattended operation is possible. Acetonitrile evaporation is achieved within 3 h, compared with 17 h for aqueous-based fractions; lower temperatures can be used during the evaporation step; mobile-phase additives, likely to form salts with the target compound if concentrated in the fraction, are removed before evaporation; sample recovery and purity are unaffected.     

Outlier removal in biomaterial image segmentations using a non-stationary Bayesian learning

Pattern Analysis and Applications - Segmentation of dried amnion biomaterial tends to produce invalid (outlier) contour point detections due to texture and colour inhomogeneity of the biomaterial....     

Managing empowerment and control in an intranet environment

Abstract. An intranet increases in sophistication and complexity as it evolves. This evolution leads to an increasing need for control over the intranet. However, this is a contentious issue, as an intranet is deemed to be an empowering technology. Consequently, intranet control systems must balance empowerment and control so as not to negate each other. This paper investigates intranet control activities and their effect on users' perceptions of empowerment throughout the evolution of an intranet in Hewlett Packard (Ireland). The growth of the intranet is charted as a six-stage model that illustrates an evolution of purpose, control and empowerment. The control strategies for managing the intranet implemented at each stage are investigated, and their resultant effects on empowerment are evaluated. The study reveals the importance of balancing control strategies with empowerment initiatives in managing intranet environments. Based on the evidence available, the study recommends the implementation of specific controls at particular stages in the evolution of an intranet in order to achieve control systems that balance empowerment and control.     

Sheldon H. White (1928-2005).

Sheldon "Shep" Harold White, one of developmental psychology's most distinguished scholars, died on March 17, 2005, at the age of 76. He is perhaps best remembered for his sharp intellect, generous spirit, good humor, and warm compassion. Shep's principal work lay in three intermeshed areas: children's learning and cognitive development, social programs and policies, and the history of developmental psychology. Shep White is sorely missed by his family and friends, and countless children have unknowingly benefited from his research, scholarship, and contributions to public policy. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The role of dorsal hippocampus and basolateral amygdala NMDA receptors in the acquisition and retrieval of context and contextual fear memories.

The authors used 3-phase context preexposure facilitation methodology to study the contribution of N-methyl-D-aspartate (NMDA) receptors in dorsal hippocampus (DH) and the basal lateral region of the amygdala (BLA) to (a) acquisition of the context memory, (b) retrieval of the context memory, (c) acquisition of context-shock association, and (d) retrieval of the context-shock association. The NMDA receptor antagonist D-2-amino-5 phosphonopentanoic acid (D-AP5) was injected into either the DH or BLA prior to (a) the context preexposure phase, (b) the immediate shock phase, or (c) the test for contextual fear. Antagonizing NMDA receptors in the DH impaired the acquisition of the context memory but did not affect its retrieval or retrieval of the fear memory. Antagonizing NMDA receptors with D-AP5 in the BLA impaired acquisition of the context-shock association but had no effect on the expression of fear. However, both DL-AP5 and L-AP5 reduced the expression of fear when they were injected into the amygdala prior to testing for contextual fear. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Integrating writing into psychotherapy practice: A matrix of change processes and structural dimensions.

Research on therapeutic writing indicates that it can offer a range of physical and psychological benefits. There is no consensus, however, concerning how writing achieves these benefits. To address this question, the authors propose a matrix framework with emotional-cognitive change processes (what can be activated) along its horizontal dimension and abstract-concrete structure (how the processes are activated) along its vertical dimension. On the horizontal dimension, writing can encourage clients who are distant from their emotional world to approach or to modulate emotional intensity, and to create meaning and coherence. Along the vertical dimension, these processes can be activated through tasks that vary in structure, including programmed writing, diaries, journaling, autobiography, storytelling, and poetry. Finally, the authors consider constraints on writing that apply to particular client groups. The matrix framework is meant to encourage clinicians to use therapeutic writing and to assist researchers in framing questions to advance our knowledge of writing as a therapeutic practice. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

PolyMat: an efficient Matlab code for multi-material topology optimization

Structural and Multidisciplinary Optimization - We present a Matlab implementation of topology optimization for compliance minimization on unstructured polygonal finite element meshes that...     

Experimental evaluation of a multivariable adaptive nonlinear predictive controller

A new multivariable adaptive nonlinear predictive controller is designed using a general nonlinear input-output model and variable transformations. The controller is similar in form to typical linear predictive controllers can be tuned analogously or by specifying a single parameters for each controlled variable. In addition, the design procedure is computationally efficient. The new controller is compared to a multi-loop proportional-integral (PI) controller with one-way static decoupling and to an adaptive linear predictive controller through tests on a simulated nonlinear distillation column. The new controller performed well in an experimental application to a multicomponent distillation column.     

Data‐Driven Bending Elasticity Design by Shell Thickness

We present a method to design the deformation behavior of 3D printed models by an interactive tool, where the variation of bending elasticity at different regions of a model is realized by a change in shell thickness. Given a soft material to be used in 3D printing, we propose an experimental setup to acquire the bending behavior of this material on tubes with different diameters and thicknesses. The relationship between shell thickness and bending elasticity is stored in an echo state network using the acquired dataset. With the help of the network, an interactive design tool is developed to generate non‐uniformly hollowed models to achieve desired bending behaviors. The effectiveness of this method is verified on models fabricated by different 3D printers by studying whether their physical deformation can match the designed target shape.     

Quantum dot light emitting devices for photomedical applications

While OLEDs have struggled to find a niche lighting application that can fully take advantage of their unique form factors as thin, flexible, lightweight and uniformly large‐area luminaire, photomedical researchers have been in search of low‐cost, effective illumination devices with such form factors that could facilitate widespread clinical applications of photodynamic therapy (PDT) or photobiomodulation (PBM). Although existing OLEDs with either fluorescent or phosphorescent emitters cannot achieve the required high power density at the right wavelength windows for photomedicine, the recently developed ultrabright and efficient deep red quantum dot light emitting devices (QLEDs) can nicely fit into this niche. Here, we report for the first time the in‐vitro study to demonstrate that this QLED‐based photomedical approach could increase cell metabolism over control systems for PBM and kill cancerous cells efficiently for PDT. The perspective of developing wavelength‐specific, flexible QLEDs for two critical photomedical fields (wound repair and cancer treatment) will be presented with their potential impacts summarized. The work promises to generate flexible QLED‐based light sources that could enable the widespread use and clinical acceptance of photomedical strategies including PDT and PBM.