Reflex-inhibiting stimuli and the refractory period of the acoustic startle reflex in the rat.

Previous studies show that if acoustic startle stimuli are presented in pairs, then the reaction to the 2nd stimulus (S2) is reduced, with the size of the refractory decrement determined by the interstimulus interval and the relative intensity of the 1st stimulus (S1). If a neutral stimulus (p) is presented just prior to S1, then the reaction to S1 is similarly inhibited, revealing the phenomenon of prestimulus inhibition. In 2 experiments with male albino Holtzman rats (N = 24) it was found that suppression of the reflex to S2 by S1 was unaffected by prestimulus inhibition of S1 (i.e., reflex amplitudes associated with S2 were identical in pS1-S2 series and S1-S2 series). In contrast, a reduction in the intensity of S1 relative to S2 did reduce the effect of S1 on S2. These data indicate that prestimulus inhibition of the reflex to S1 does not result because the preliminary stimulus attenuates the sensory impact of S1. The inhibitory process may be presumed to have a central locus. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of nicotine dose and administration method on withdrawal symptoms and side effects during short-term smoking abstinence.

The effects of using several different nicotine replacement treatments on self-reported withdrawal symptoms and side effects during 2-day periods of smoking cessation, with 5 days of ad lib smoking between cessation days, were evaluated. Participants (N ?=?18) experienced the following conditions: nicotine gum, 24-hr patch, 16-hr patch, 24-hr patch plus gum, double 24-hr patch, and no nicotine replacement. The present study found morning urge to smoke was greater during the 16-hr than during the 24-hr patch condition. Double-patch use resulted in significantly greater insomnia than the smoking baseline and 16-hr patch conditions. The no medication and gum alone conditions resulted in similar withdrawal symptoms, and both tended to result in greater reported withdrawal symptoms than the smoking baseline condition. There were no significant withdrawal symptom differences between the 24-hr, patch-gum, and double-patch conditions. The 24-hr and double-patch conditions were preferred by two thirds of the participants (6 each). (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Variation and Distribution: Forest Patterns as a Model for Urban Morphologies

What can we learn from the spatial logic of collections of trees in the rainforest? Evan Greenberg of the EmTech programme at the Architectural Association (AA) School of Architecture in London and George Jeronimidis of the Centre for Biomimetics at the University of Reading combine forces to analyse the rainforest's morphology and its potential as an urban model. They suggest how the sectional height differentiation of trees could present a new way of thinking about urban organisation, accommodating varied microclimates, programmes and the city's infrastructural flows.     

Distributed dynamic lane reversal and rerouting for traffic delay reduction

Traffic congestion is a major source of delays in modern road networks. Motivated by this, we propose two distributed algorithms to reduce delays: a dynamic lane reversal algorithm and a rerouting algorithm. When there is a density imbalance on a road, time can be saved by reallocating lanes from the less dense side to the more dense side, which motivates dynamic lane reversal. When a road has greater density than nearby roads, time can be saved by redirecting flow into the least congested roads, this motivates dynamic rerouting. Given a communication system between infrastructure and vehicles on the road, the local state of the network can be approximated and utilised by the algorithms to minimise travel time. In order to provide a better fundamental understanding of the system dynamics, we analyse equilibrium conditions for the system and prove convergence of the lane reversal algorithm to a critical point. Overall performance is also examined in simulation.     

Battery cell modeling and online estimation of the state of charge of a lithium-ion battery

Battery models are vital to the development of electric vehicles. Different models have been proposed over the years to describe the battery dynamics in various degree of detail. More detail comes at the cost of more computation. This paper proposes using a combination of the Kinetic Battery Model (KiBaM) and the dual capacity network model to capture both the nonlinear state of charge variation and linear transient response. After capture, we then derived a recursive formula for the online implementation of the proposed model. In the first part of this study, MATLAB® was used to build a battery model of a battery cell. The battery model simulates how the magnitude of the discharge current and state of charge influence the parameters of the model, with the results showing that it can predict the voltage response within a voltage error of 4% under dynamic loading. In the second part of the study, a model-based Kalman filter was adopted for estimating the state of charge. This algorithm was compatible with the recursive formula and could be used in conjunction with the online batter model.     

Insight from in situ microscopy into which precipitate morphology can enable high strength in magnesium alloys

Magnesium alloys, while boasting light weight, suffer from a major drawback in their relatively low strength. Identifying the microstructural features that are most effective in strengthening is therefore a pressing challenge. Deformation twinning often mediates plastic yielding in magnesium alloys. Unfortunately, due to the complexity involved in the twinning mechanism and twin-precipitate interactions, the optimal precipitate morphology that can best impede twinning has yet to be singled out. Based on the understanding of twinning mechanism in magnesium alloys, here we propose that the lamellar precipitates or the network of plate-shaped precipitates are most effective in suppressing deformation twinning. This has been verified through quantitative in situ tests inside a transmission electron microscope on a series of magnesium alloys containing precipitates with different morphology. The insight gained is expected to have general implications for strengthening strategies and alloy design.     

Mandibular morphology,task specialization and bite mechanics in Pheidole ants (Hymenoptera: Formicidae)

Ants show remarkable ecological and evolutionary success due to their social life history and division of labour among colony members. In some lineages, the worker force became subdivided into morphologically distinct individuals (i.e. minor versus major workers), allowing for the differential performance of particular roles in the colony. However, the functional and ecological significance of these morphological differences are not well understood. Here, we applied finite element analysis (FEA) to explore the biomechanical differences between major and minor ant worker mandibles. Analyses were carried out on mandibles of two Pheidole species, a dimorphic ant genus. We tested whether major mandibles evolved to minimize stress when compared to minors using combinations of the apical tooth and masticatory margin bites under strike and pressure conditions. Majors performed better in pressure conditions yet, contrary to our expectations, minors performed better in strike bite scenarios. Moreover, we demonstrated that even small morphological differences in ant mandibles might lead to substantial differences in biomechanical responses to bite loading. These results also underscore the potential of FEA to uncover biomechanical consequences of morphological differences within and between ant workers.     

Unrestricted ramping rates and long‐term trends in the food web metrics of a boreal river

Long‐term monitoring of the food web of a regulated hydropeaking river was conducted to assess if previously documented effects of changing ramping rates (RRs) were maintained with the addition of 6 years of data. Using carbon and nitrogen stable isotope analyses, we hypothesized that: (1) macroinvertebrates and fish inhabiting areas below peaking hydrodams would be higher in δ¹⁵N and lower in δ¹³C due to increased flow velocity and the influence of light respired dissolved inorganic carbon, relative to those sampled from areas with a natural flow regime; (2) the increase in δ¹⁵N of macroinvertebrates would lead a shorter food web length in the regulated river, but δ¹³C and niche width would be similar between the restricted and unrestricted RR periods (i.e., the BACI analysis); and (3) isotopic metrics (e.g., δ¹³C, δ¹⁵N, niche width [SEA_B], and food chain length [Δ¹⁵N]) would correlate with variations in flow characteristics through time. Consistent with previous analysis conducted over a shorter time period, a shift toward higher δ¹⁵N values was observed for both fish and invertebrates, but, contrarily, only invertebrates (not fish) had a lower δ¹³C value downstream of the dam. Over the long term, the before‐after‐control‐impact analysis found no effect of RRs on any of the food web metrics, implying that the change in operation did not affect the river food web. However, analysis of the time series data indicated that flow metrics and trophic metrics were often correlated, including a negative effect of RR (invertebrates) and discharge (fish) on food chain length. This study illustrates the difficulty in detecting changes in food web structure and function under changing flow regime influenced by natural and anthropogenic effects. As such, this study highlights the need for considering large spatial and temporal scales to differentiate between confounding effects of climate, natural variability, and altered flow regimes on food webs in regulated rivers.     

Light Amplification and Efficient Electroluminescence from a Solution-Processable Diketopyrrolopyrrole Derivative via Triplet-to-Singlet Upconversion

Over the years, achieving efficient electroluminescence (EL) while simultaneously having low light amplification thresholds under optical excitation has been the key to progression toward the long-thought objective of electrically pumped organic lasers. While significant progress in this regard has been made for organic semiconductors emitting in the blue–green region of the visible spectrum, organic laser dyes with low-energy emission (>600 nm) still suffer from high amplified spontaneous emission (ASE) thresholds and low external quantum efficiencies (EQEs) in devices. Herein, low ASE thresholds and efficient EL are reported from a solution-processable organic laser dye dithiophenyl diketopyrrolopyrrole (DT-DPP). The ASE threshold of 4 µJ cm⁻² at the wavelength of 620 nm is obtained while making constructive use of triplet excitons by doping DT-DPP in a green-emitting host matrix, which exhibits thermally activated delayed fluorescence (TADF). The organic light-emitting diode fabricated from this system gives a high EQE of 7.9% due to the efficient utilization of triplet excitons. Transient EL studies further show that a high reverse intersystem crossing rate is crucial in achieving lasing under electrical pumping from such TADF-assisted fluorescent systems.     

Comparison of anaerobic dechlorinating enrichment cultures maintained on tetrachloroethene,trichloroethene, cis-dichloroethene and vinyl chloride

An anaerobic mixed microbial culture was enriched from soil and groundwater taken from a site contaminated with trichloroethene (TCE). This enrichment culture was divided into four subcultures amended separately with either perchloroethene (PCE), TCE, cis-dichloroethene (cDCE) or vinyl chloride (VC). In each of the four subcultures, the chlorinated ethenes were rapidly, consistently, and completely converted to ethene at rates of 30-50 micromol/l of culture per day, or an average 160 micro-electron equivalents/l of culture per day. These cultures were capable of sustained and rapid dechlorination of VC, and could not dechlorinate 1,2-dichloroethane, differentiating them from Dehalococcoides ethenogenes, the only known isolate capable of complete dechlorination of PCE to ethene. Chloroform (CF) and 1,1,1-trichloroethane, frequent groundwater co-contaminants with TCE and PCE, inhibited chlorinated ethene dechlorination. Most strongly inhibited was the final conversion of VC to ethene, with complete inhibition occurring at an aqueous CF concentration of 2.5 microM. Differences in rates and community composition developed between the different subcultures, including the loss of the VC enrichment culture's ability to dechlorinate PCE. Denaturing gradient gel electrophoresis of amplified bacterial 16S rRNA gene fragments identified three different DNA sequences in the enrichment cultures, all phylogenetically related to D. ethenogenes. Based on the PCR-DGGE results and substrate utilization patterns, it is apparent that significant mechanistic differences exist between each step of dechlorination from TCE to ethene, especially for the last important dechlorination step from VC to ethene.