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11.
Nanotechnology research is booming worldwide, having an impact on multiple sectors and with a general belief that medical
and biological applications will form the greatest area of expansion over the next decade, driven by an attempt to bring radical
solutions to areas of unmet medical need. What is true in the USA is also being fulfilled in Europe, though generally at a
significantly lower investment level, even for ’large’ capital infrastructure and interdisciplinary centres. Against this,
the UK and its European partners are following the maxim ’small is beautiful’ and are attempting to identify and grow academic
research and commercial businesses in areas that traditional nanotechnology developments out of engineering or physics find
challenging. Thus, University College London and Imperial College, in a major joint project linked to other centres of excellence
both in the UK and in the rest of Europe, are building upon their internationally competitive medical and hard-matter research
activities to focus on and develop nanotechnology as a major sector of research activity. The two universities together form
one of the largest centres of biomedical research outside the USA. A novel approach to commercialisation has been taken, exemplified
by the establishment with government and private equity funds of a ‘Bionanotechnology Centre’ — this will act as a portal
for UK industry to access specialist skills to solve issues relating to developing nanotechnology-based medical applications,
for example, for environmental screening, diagnostics and therapy. This paper reviews our academic and business strategy with
examples from our current research portfolio, biased towards medicine as the London Centre for Nanotechnology’s most rapidly
growing area. 相似文献
12.
KS Min AR Khan MK Kwon YJ Jung Z Yun Y Kiso 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2005,80(8):909-915
The performance of a laboratory‐scale anaerobic acidogenic fermenter fed with a mixture of blended kitchen food‐waste and primary sludge from a sewage treatment plant was investigated for the production of volatile fatty acids (VFA). The operating variables for acidogenic fermentation were kitchen food‐waste content (10 and 25 wt %), hydraulic retention time (HRT: 1, 3 and 5 days), temperature (ambient: 18 ± 2 °C, and mesophilic: 35 ± 2 °C) and pH (varied from 5.2 to 6.7). The experimental results indicated that effluent VFA concentrations and VFA production rates were higher at ambient temperature than at mesophilic conditions. The net amount of VFA with 10 wt % food‐waste increased up to 920 mg dm?3 with an increase of HRT, but contrasting results (a decrease of 2610 mg dm?3) were found due to the conversion of VFA into biogas in the case of 25 wt % food‐waste, which increased significantly at HRT of 3–5 days. In terms of biogas composition (CO2 and CH4), the organic matter was converted into CO2 through the oxidative pathway by facultative species at low temperature while mesophilic temperature and optimum pH (6.3–7.8) played a pivotal role in increasing rate of conversion of VFA into biogas by methanogenesis. Rates of VFA production and their conversion are dependent on the food‐waste content in the mixture. Yet, the higher concentration of food‐waste (25% compared with 10%) did not produce VFA proportionally due to the increased rate of conversion of VFA into gaseous products. The maximum VFA production rate (0.318 g VFAproduced g?1 VSfed day?1) was achieved in the 10 wt % food‐waste at ambient temperature and at a 5‐day HRT. Copyright © 2005 Society of Chemical Industry 相似文献
13.
An experimental study of heat transfer to boiling liquids under natural convective flow has been carried out in a single tube vertical thermosiphon reboiler to investigate the effect of heat flux and submergence on circulation rates. The test liquids used were distilled water, various concentrations of propan-2-ol in water and their azeotrope. The test section was an electrically heated stainless steel tube of 25.56 mm i.d., 28.85 mm o.d. and 1900 mm long with twenty-one spot welded copper constantan thermocouples to measure the variations in wall temperature along its axis. The uniform heat fluxes in the range of 3.5–42.4 kW/m2 were employed while inlet liquid sub-cooling varied from 0.2 to 30.7 °C. The liquid submergence levels were maintained in the range 30–100%. The typical experimental data has been graphically presented and discussed. An empirical correlation has been developed from the experimental data of the present study through regression analysis. 相似文献
14.
Sanghyun Ju Jianye Li Pimparkar N. Alam M.A. Chang R.P.H. Janes D.B. 《Nanotechnology, IEEE Transactions on》2007,6(3):390-395
Nanorod field-effect transistors (FETs) that use multiple Mg-doped ZnO nanorods and a SiO2 gate insulator were fabricated and characterized. The use of multiple nanorods provides higher on-currents without significant degradation in threshold voltage shift and subthreshold slopes. It has been observed that the on-currents of the multiple ZnO nanorod FETs increase approximately linearly with the number of nanorods, with on-currents of ~1 muA per nanorod and little change in off-current (~4times10-12). The subthreshold slopes and on-off ratios typically improve as the number of nanorods within the device channel is increased, reflecting good uniformity of properties from nanorod to nanorod. It is expected that Mg dopants contribute to high n-type semiconductor characteristics during ZnO nanorod growth. For comparison, nonintentionally doped ZnO nanorod FETs are fabricated, and show low conductivity to compare with Mg-doped ZnO nanorods. In addition, temperature-dependent current-voltage characteristics of single ZnO nanorod FETs indicate that the activation energy of the drain current is very low (0.05-0.16 eV) at gate voltages both above and below threshold 相似文献
15.
Syed M. Alam Donald E. Troxel Carl V. Thompson 《Analog Integrated Circuits and Signal Processing》2003,35(2-3):199-206
In this paper, we describe a comprehensive layout methodology for bonded three-dimensional integrated circuits (3D ICs). In bonded 3D integration technology, parts of a circuit are fabricated on different wafers, and then, the wafers are bonded with a glue layer of Cu or polymer based adhesive. Using our layout methodology, designers can layout such 3D circuits with necessary information on inter-wafer via/contact and orientation of each wafer embedded in the layout. We have implemented the layout methodology in 3DMagic. Availability of 3DMagic has led to interesting research with a wide range of layout-specific circuit evaluation, from performance comparison of 2D and 3D circuits to layout-specific reliability analyses in 3D circuits. Using 3DMagic, researchers have designed and simulated an 8-bit encryption processor mapped into 2D and 3D FPGA layouts. Moreover, the layout methodology is an essential element of our ongoing research for the framework of a novel Reliability Computer Aided Design tool, ERNI-3D. 相似文献
16.
An analytical method for calculating static characteristics of linear dc step motors (LSM) is described. These multiphase passive-armature motors are now being developed for control rod drives (CRD) in large nuclear reactors. The static characteristics of such LSM is defined by the variation of electromagnetic force with armature displacement and it determines motor performance in its standing and dynamic modes of operation. The proposed analytical technique for calculating this characteristic is based on the permeance analysis method applied to phase magnetic circuits of LSM. Reluctances of various parts of phase magnetic circuit is calculated analytically by assuming probable flux paths and by taking into account complex nature of magnetic field distribution in it. For given armature positions stator and armature iron saturations are taken into account by an efficient iterative algorithm which gives fast convergence. The method is validated by comparing theoretical results with experimental ones which shows satisfactory agreement for small stator currents and weak iron saturation 相似文献
17.
18.
For viruses made of nucleic acid and protein, the structure of the protein outer shell has, in the past, been found to be uniquely determined by the viral genome. However, here, non-denaturing agarose gel electrophoresis of bacteriophage T7 reveals two states of the mature T7 capsid; the conditions of growth are found to alter the population by T7 of these two electrophoretically defined states. Both states have been previously observed for a genetically altered T7 and they are observed here for wild-type T7. The average electrical surface charge density of a bacteriophage particle (delta) determines its state; the delta of particles in both states is negative. For a given condition of growth, the population of these two states is influenced by the extent to which the major T7 outer shell protein, p10A, is accompanied by its minor readthrough variant, p10B. Comparison of the two electrophoretic states reveals the following. (1) No difference in radius is present in the outer shell (+/-2%). (2) As the pH of electrophoresis is either increased or decreased from neutrality, the state becomes more highly populated for which delta is greater in magnitude (state 1). By changing the pH, some T7 particles are made to change state. (3) Particles in state 1 adsorb less quickly to host cells than do the particles in the alternative state (state 2). This latter observation suggests the hypothesis that state 1 evolved to reduce the probability of re-initiating an infection when conditions are not favorable for growth. This hypothesis is supported by the observation that, as conditions of growth become apparently more unfavorable, progeny increasingly populate state 1. 相似文献
19.
S el-Shoura A Sheikha M al-Janadi N Morad AR Khan A Westmuckett 《Canadian Metallurgical Quarterly》1993,34(4):259-264
The ultrastructural features of histiocytes in the bone marrow (BM) were studied in a febrile, splenomegalic and pancytopenic Sudanese patient who was diagnosed by one of us as visceral leishmaniasis (VL) associated with low level of parasitaemia and mimicking malignant histiocytosis (MH). Serial thick (STS) and ultrathin (SUT) sections showed that the BM was hypercellular and markedly infiltrated by large histiocytes with prominent phagocytosis. A thorough examination of various ST and UT section revealed only a single, typical Leishman-Donovan body. At transmission electron microscopy (TEM) level, two principal types of histiocytic cells were identified: Type I, subdivided into two subtypes, were actively phagocytic histiocytes (PH) with large digestive vacuoles and primary lysosomes; type II were nonphagocytic histiocytes (nPH) with primary lysosomes only. The rate of PH to nPH ws 7:2 in plastic STS. The interaction between the PH and ingested cells is described. Both types of cell were morphologically similar to previously described malignant histiocytic cells. However, this study showed a better characterization of PH during VL. 相似文献
20.