Biomedical applications of mRNA nanomedicine

As an attractive alternative to plasmid DNA, messenger RNA (mRNA) has recently emerged as a promising class of nucleic acid therapeutics for biomedical applications. Advances in addressing the inherent shortcomings of mRNA and in the development of nanoparticle-based delivery systems have prompted the development and clinical translation of mRNA-based medicines. In this review, we discuss the chemical modification strategies of mRNA to improve its stability, minimize immune responses, and enhance translational efficacy. We also highlight recent progress in nanoparticle-based mRNA delivery. Considerable attention is given to the increasingly widespread applications of mRNA nanomedicine in the biomedical fields of vaccination, protein-replacement therapy, gene editing, and cellular reprogramming and engineering.     

卷积积分和拉普拉斯变换在一阶电路中的应用

电路的任意激励的零状态响应,可以用卷积积分和拉普拉斯交换的方法求解。本文通过两个一阶电路的实例,阐述了两种方法的应用特点。     

基于水印和密码的数字版权管理模型的研究

在分析了数字版权研究现状和功能框架的基础上,设计了基于多重数字水印和密码的版权管理模型;该模型采用数字内容和许可证各自单独封装、独立分发的方式,使得只有购买了许可证的特定用户才能使用数字内容,实现了水印作品的许可交易;另外,内容服务器采用的对数字作品加载两次水印,对数字内容部分签名加密,未加密部分签名的方案,在有效保证数字内容安全传输的基础上又减少了计算量和存储量;分析表明该模型有显著的优点和很好的安全性。     

Issues and solution on distortion drift in reversible video data hiding

Different from reversible image data hiding, most reversible video data hiding schemes have the particular problem that the distortion due to hidden data will spread and accumulate. In this paper, the problem of distortion drift caused by reversible data hiding in compressed video is analyzed, and a lossless drift compensation scheme is proposed to restrain the distortion for the first time. In order to ensure the reversibility, drift compensation signals are merged in the quantized DCT (Discrete Cosine Transform) coefficients of P-frames and the corresponding recovery mechanism is presented as well. Experimental results demonstrate that the proposed lossless drift compensation scheme significantly improves the video quality, and the original compressed video can be recovered exactly after the hidden data and compensation signals are removed. In addition, the proposed scheme does not depend on specific reversible data hiding method.     

略谈平面设计中的触觉体验

本文通过对触觉设计这一设计理念的论述,探讨材质在平面设计中的表现以及如何在平面设计中合理的运用触觉感受来传达信息,提高设计品质。     

一种基于可信度矩阵的多传感器目标识别方法

为了解决多传感器目标识别中不同等级信息源数据的融合问题,在研究DSmT证据理论的基础上,引入证据可信度矩阵.依据可信度矩阵对证据进行转化,使之可以用传统的方法进行证据融合.将这种方法应用到等级不同的多传感器目标识别中,可以解决传统证据理论只能进行相同等级传感器目标识别的难题.仿真实验表明,该方法提高了目标识别的准确性和有效性.     

汽车电动助力转向器的控制器研制

研究了日本N4样机的电动助力转向系统的电机电流-输入扭矩特性.采用ATmega16L单片机为处理器,以直流有刷电机为执行器,应用PID补偿算法,设计了电动助力转向控制器.在试验台上进行了电机电流-输入扭矩特性试验,试验结果表明,该控制器的助力曲线接近日本N4样机,能取得比较满意的助力效果.     

Evaluation of Landsat 8 OLI imagery for unsupervised inland water extraction

The successful launch of the Landsat 8 satellite continues the Earth observation of the Landsat series, which has been taking place for nearly 40 years. With the increase in the band number and the improved spectral range compared with the previous Landsat imagery, it will be possible to expand the application of the new Landsat 8 imagery. The purpose of this study is to explore water extraction based on the new Landsat 8 Operational Land Imager (OLI) imagery. According to the specific inland water conditions (clear water, turbid water, and eutrophic water), a number of highly adaptable water indices are assessed for water extraction using Landsat OLI imagery. The results show that clear water is the easiest to extract among the different types of waterbodies, with the highest average accuracy of 97%. The highest-accuracy methods are the automated water extraction index for shadow pixels (AWEI_sh), the normalized difference water index using bands 4 and 7 (NDWI₄₇), and the normalized difference water index using bands 3 and 7 (NDWI₃₇), with accuracies of 98.55%, 95.50%, and 96.61%, corresponding to clear water, turbid water, and eutrophic water, respectively. Through the analysis of the different methods for optimal band selection, the seventh band OLI7 (shortwave infrared 2, SWIR-2) of Landsat OLI shows the best performance in water identification. When applying the water indices to water extraction, Otsu’s algorithm has been used to automatically select the water threshold. Using extensive experiments with Otsu’s algorithm and a manual method, it was found that Otsu’s algorithm can replace manual selection and has the ability to select an accurate threshold for water extraction.