Methods for Biomimetic Remineralization of Human Dentine: A Systematic Review

This study aimed to review the laboratory methods on biomimetic remineralization of demineralized human dentine. A systematic search of the publications in the PubMed, TRIP, and Web of Science databases was performed. Titles and abstracts of initially identified publications were screened. Clinical trials, reviews, non-English articles, resin-dentine interface studies, hybrid layer studies, hybrid scaffolds studies, and irrelevant studies were excluded. The remaining papers were retrieved with full texts. Manual screening was conducted on the bibliographies of remaining papers to identify relevant articles. A total of 716 studies were found, and 690 were excluded after initial screening. Two articles were identified from the bibliographies of the remaining papers. After retrieving the full text, 23 were included in this systematic review. Sixteen studies used analogues to mimic the functions of non-collagenous proteins in biomineralization of dentine, and four studies used bioactive materials to induce apatite formation on demineralized dentine surface. One study used zinc as a bioactive element, one study used polydopamine, and another study constructed an agarose hydrogel system for biomimetic mineralization of dentine. Many studies reported success in biomimetic mineralization of dentine, including the use of non-collagenous protein analogues, bioactive materials, or elements and agarose hydrogel system.     

A Series of New Ligustrazine-Triterpenes Derivatives as Anti-Tumor Agents: Design,Synthesis, and Biological Evaluation

A series of novel ligustrazine-triterpenes derivatives was designed, synthesized and screened for their cytotoxicity against five cancer cell lines (Bel-7402, HepG2, HT-29, Hela, and MCF-7) and Madin-Darby canine kidney (MDCK). Current study suggested that most of the ligustrazine-triterpenes conjunctions showed better cytotoxicity than the starting materials. In particular, compound 4a exhibited better cytotoxic activity (IC₅₀ < 5.23 μM) against Bel-7402, HT-29, MCF-7, Hela, and HepG2 than the standard anticancer drug cisplatin (DDP). The cytotoxicity selectivity detection revealed that 4a exhibited low cytotoxicity (IC₅₀ > 20 μM) towards MDCK cells. A combination of fluorescence staining observation and flow cytometric analysis indicated that 4a could induce HepG2 cell apoptosis. Further studies suggested that 4a-induced apoptosis is mediated through depolarization of the mitochondrial membrane potential and increase of intracellular free Ca²⁺ concentration. In addition, the structure-activity relationships of these derivatives were briefly discussed.     

新时代古城保护策略刍议 ——以泰安古城为例

古城是一地历史文化的外在表现,是人类共有的文化遗产,在历史文脉传承、城市规划建设、文物遗迹保护等多方面具有重要价值.恢复老城区的功能和活力是新时期展示城市文化底蕴、激活发展动力、实现绿色发展、提升城市影响力的关键所在,是城市发展的核心竞争力.有效保护古城,留住城市特有的地域环境、文化特色、建筑风格等"基因"意义深远.基于此,文章以泰安古城为例,充分挖掘古城历史文化元素,针对存在问题,深入分析古城的地位和价值,根据古城现状及未来发展研究,探索提出新时期古城保护、城市复兴的策略和实施建议.     

东黄山国际小镇串珠状隐伏溶洞顶板稳定性研究

地下岩溶发育破坏了岩体的完整性,导致岩体的强度和承载力大幅度降低,对工程场地地基稳定性构成潜在的威胁.本文依托东黄山国际小镇基础设施项目,在采用多种勘察手段相结合的方法确定岩溶发育特征的基础上,选取代表性的溶洞,采用按溶洞顶板安全厚度判别的定性评价方法和按顶板坍塌自行填塞判别、顶板抗弯安全厚度判别、按顶板抗剪安全厚度判别3种半定量评价方法对溶洞顶板安全厚度进行综合判别,对岩溶地基进行稳定性评价.研究结果表明:研究区揭露岩溶主要以覆盖型串珠状溶洞为主,多为充填型溶洞,选取的117个典型溶洞大多处于稳定状态,在自然状态下顶板稳定性较好,发生坍塌的可能性小.     

结构优化对风机叶轮焊接残余应力和稳态运行的影响

本文利用大型通用有限元软件ANSYS,分析了15Mn Ni Cr Mo V离心式压缩机叶轮在不同叶片结构下焊接残余应力和运行应力的变化。结果表明:未进行结构优化之前,叶轮在焊接后的残余应力和正常运行时所受到的运行应力均较大,但是叶轮在经过叶片切割6°、12°和25°的结构调整后,叶轮焊后残余应力均明显降低,叶轮整体的残余应力最大降低了46.4%,叶片残余应力最大降低了53.6%。但是,随着叶片切割角度的增大,叶轮的运行应力却逐渐增加,而且切割25°后的叶轮运行应力超过了材料的屈服强度。     

冷弯超薄壁C型钢墙梁节点抗震性能试验研究

对3个冷弯超薄壁C型钢组合墙体与组合楼盖连接的墙梁节点足尺试件进行拟静力试验,讨论不同墙架柱截面、不同轴压比对墙梁节点承载力、耗能能力的影响,得到了各节点的破坏特征、承载力特征值、延性和耗能系数。结果表明:墙架柱截面对冷弯超薄壁C型钢墙梁节点的抗震性能影响较大,C160mm×40mm×10mm×1mm截面试件的承载力是C89mm×44.5mm×12mm×1mm截面试件的1.5倍,延性系数约1.1倍。轴压比对冷弯超薄壁C型钢墙梁节点的抗震性能影响明显,0.4的轴压比下C160mm×40mm×10mm×1mm截面试件的承载力是0.2的轴压比时的2/3,延性系数约1/2。     

城市轨道交通“综合接驳”概念的建立及其特性

城市空间与行为集体特征总是相互影响的。"接驳"作为城市空间与轨道交通的连接关键,相关研究多从交通层面出发,缺乏更大范围的城市空间一体化视角。在原有相对狭义的"接驳"概念基础上提出"综合接驳"概念。通过调研重庆等多个城市的典型站点,解析站点影响域、交通行为与非交通行为等多个基本要素,从而明确"综合接驳"的概念。据此进一步建立起城市轨道交通综合接驳的特性及层级目标,初步揭示了城市空间与综合接驳的关联机制,为站点影响域空间优化奠定了实证研究基础。     

黑龙江省某钼矿石选矿试验研究

黑龙江省某钼矿原矿Mo品位0.062%,试验分别进行了磨矿细度、浮选药剂用量、浮选时间等条件试验研究,并在此基础上进行了两种闭路流程试验对比研究,最终确定较为合理的试验流程,并获得Mo品位为49.23%,回收率为87.98%的精矿产品,选矿效果较好。本研究为该矿区地质评价及矿产资源开发利用提供了有利依据。      

基于改进型虚拟同步发电机的功率控制

针对传统虚拟同步发电机(Virtual Synchronous Generator,VSG)控制中逆变器输出阻抗和线路阻抗不同而引起的功率环流问题,提出一种改进型虚拟同步发电机功率控制方法。首先,在VSG电磁方程中引入虚拟电抗,解决低压线路阻抗模型中阻性成分带来的功率耦合问题,使得逆变器输出功率能够独立控制。其次,在VSG励磁控制器中附加公共连接点电压(Voltage at the Point of Common Coupling,VPCC)调节器,抑制因线路阻抗不同而引起的无功环流,并可在负荷突增情况下维持VPCC稳定。最后在孤岛运行的低压微电网中进行了仿真,仿真结果证明了该控制策略的可行性与有效性。     

PE-g-MAH增容改性LDPE/橡实壳纤维复合材料的研究

采用熔融挤出法制备了低密度聚乙烯(LDPE)/橡实壳纤维(AS)木塑复合材料.研究了增容剂聚乙烯接枝马来酸酐(PE-g-MAH)对LDPE/AS木塑复合材料的影响.结果表明,PE-g-MAH是一种优良的增容剂,当其质量分数为5%时,LDPE/AS复合材料的拉伸强度比未添加时提高77.6%,弯曲强度提高83.8%,缺口冲击强度基本保持在5.0 kJ/m2.SEM分析表明,PE-g-MAH改善了AS与LDPE基体材料的相容性.DMA和DSC测试表明,PE-g-MAH能有效改善两相之间的界面相容性,并从根本上改善LDPE基体材料的性能.