Solving distributed FMS scheduling problems subject to maintenance: Genetic algorithms approach

In general, distributed scheduling problem focuses on simultaneously solving two issues: (i) allocation of jobs to suitable factories and (ii) determination of the corresponding production scheduling in each factory. The objective of this approach is to maximize the system efficiency by finding an optimal planning for a better collaboration among various processes. This makes distributed scheduling problems more complicated than classical production scheduling ones. With the addition of alternative production routing, the problems are even more complicated. Conventionally, machines are usually assumed to be available without interruption during the production scheduling. Maintenance is not considered. However, every machine requires maintenance, and the maintenance policy directly affects the machine's availability. Consequently, it influences the production scheduling. In this connection, maintenance should be considered in distributed scheduling. The objective of this paper is to propose a genetic algorithm with dominant genes (GADG) approach to deal with distributed flexible manufacturing system (FMS) scheduling problems subject to machine maintenance constraint. The optimization performance of the proposed GADG will be compared with other existing approaches, such as simple genetic algorithms to demonstrate its reliability. The significance and benefits of considering maintenance in distributed scheduling will also be demonstrated by simulation runs on a sample problem.     

Model-based control of a simulated moving bed chromatographic process for the separation of fructose and glucose

Chromatographic separations are an expanding technology for the separation of high value products, particularly in the area of pharmaceutics, food, and fine chemicals. The simulated moving bed (SMB) process as a continuous chromatographic separation process is an interesting alternative to conventional batch chromatography, and gained more and more impact recently. The SMB process is realized by connecting several single chromatographic columns in series. A countercurrent movement of the bed is approximated by a cyclic switching of the inlet and outlet ports in the direction of the fluid stream. Because of its complex dynamics, the optimal operation and automatic control of SMB processes is a challenging task. This paper presents the design of a model-based optimization and control scheme for SMB chromatographic separation processes and its application to the separation of fructose and glucose. We propose a two-layer control architecture where the optimal operating trajectory is calculated off-line by dynamic optimization based on a rigorous process model. The parameters of the model are adapted based on online measurements. The low-level control task is to keep the process on the optimal trajectory despite disturbances and plant/model mismatch. Here identification models based on simulation data of the rigorous process model along the optimal trajectory are combined with a suitable local controller. The efficiency of the trajectory control algorithm is shown in a simulation study for the separation of fructose and glucose on an 8-column SMB plant.     

Applications of specialized coils for high-resolution MRI on a whole-body scanner

To investigate the application of a mini-coil surface system for high-resolution MRI, 60 volunteers were examined in a 1.5-T whole-body scanner. Two replaceable probe heads were available: a circular 2.5-cm coil and a quadratic 5-cm coil, both of which were placed directly on the skin. The skin layers, Achilles tendon and finger joints were examined with the 2.5-cm coil and a FOV of 25 × 25 mm². A matrix of 256 × 256 pixels resulted in a pixel size of 0.098 × 0.098 mm². For imaging of the carpal tunnel, the 5-cm coil was used in transverse orientation. The FOV was 50 × 50 mm² so that a matrix of 256 × 256 pixels led to a pixel size of 0.195 × 0.195 mm². The resulting spatial resolution permitted visualization of the epidermis, dermis and subcutis, resulting in clear definition of anatomical detail of the musculoskeletal system. MRI measurement of skin-layer thickness did not correlate with histometric data (p<0.05). This discrepancy was due in part to shrinkage of the tumor specimen on histologic preparation. Other causes include the motion artifacts and the limited accuracy of determining thickness on the MRI display unit.     

Tetravinyl-tetramethylcyclo-tetrasiloxane (tetravinyl D4) is a mutagen in Rat2lambda lacI fibroblasts

We describe a patient with sporadic dystrophic epidermolysis bullosa associated with well-documented atopic dermatitis. We discuss this case in relation to a newly described clinical subtype of epidermolysis bullosa known as epidermolysis bullosa pruriginosa, a dystrophic variant associated with prominent pruritus. The relations of this case of sporadic dystrophic epidermolysis bullosa with other dominantly inherited forms of dystrophic epidermolysis bullosa such as the Pasini variant, the pretibial variant, and Bart's syndrome are also discussed. The role of atopic dermatitis in exacerbating dystrophic epidermolysis bullosa in this patient raises an important consideration in the care of this group of patients.     

Hemodynamic tolerance of intravascular contrast agents for magnetic resonance imaging

RATIONALE AND OBJECTIVES: Intravascular contrast agents for magnetic resonance imaging (MRI) facilitate the quantification of tissue perfusion. The authors determined the hemodynamic tolerance of these agents. METHODS: Doses of 0.05, 0.15, and 0.45 mmol/kg of the polymeric intravascular contrast agent gadolinium-DTPA-polylysine, and di-nitrobenzyl-gadolinium-DTPA, a non-polymeric intravascular contrast agent with high protein binding, and gadolinium-DTPA dimeglumine, a paramagnetic contrast agent with extracellular distribution, were injected into 18 normal male rats as a peripheral intravenous bolus. Systolic, diastolic, and mean blood pressure, left ventricular end-diastolic and developed pressure, positive rate of pressure change (+dP/dt), dP/dt, the rate-pressure product, and heart rate were recorded during a period of 20 minutes. Hemodynamic effects were established by analysis of variance for repeated measurements. RESULTS: There was a transient increase of all blood pressure parameters and contractility for Gd-DTPA-polylysine at the dose of 0.45 mmol/kg only. Di-nitrobenzyl-Gd-DTPA increased blood pressure parameters at 0.45 mmol/kg only. At doses of 0.05 and 0.15 mmol/kg, no significant hemodynamic effects were observed. CONCLUSIONS: The authors conclude that Gd-DTPA-polylysine is hemodynamically safe at doses to 0.15 mmol/kg and acts like a plasma expander at higher doses after peripheral bolus injection in normal rats. Additional investigations are indicated to elucidate the mechanism of a nonsignificant and satiable transient hemodynamic depression after injection of 0.05 mmol/kg DNB-Gd-DTPA.     

Electronic Measuring Cup for the Blind

A simple electronic measuring cup for the blind is described. It uses an array of infrared level detectors, which are immersed in the medium to be measured. When used with a standard 1-liter glass, the filling level is indicated acoustically in increments of 50 ml.     

The effect of thermomechanical pretreatment on the allotropic transformation in cobalt

The effect of prior thermomechanical treatment on the allotropic transformation in cobalt was investigated utilizing continuous resistivity measurement, X-ray diffraction, and pole figure determinations. Initially, a significant amount of metastable cubic phase was always present at room temperature, the existence of which was independent of the prior thermomechanical treatment employed. For material fully recrystallized, a pronounced reduction in the amount of metastable cubic phase is observed in cycling through the transformation. A much less pronounced effect was observed on cycling material recovered prior to the recrystallization treatment; however, interpretation of data is less clear due to the presence of texture which was always evident. The anomalously low Residual Resistance Ratios always found in high-purity cobalt is interpreted to be due to the presence of this metastable cubic phase, since cycling resulted in significant improvements in the ratios observed. The results of this investigation are in strong disagreement with those of Bibring and Sebilleau^21–23 on the effects of prior thermomechanical treatment on the allotropic transformation in cobalt.     

Design and characterization of the balloon-borne Michelson Interferometer for Passive Atmospheric Sounding (MIPAS-B2)

MIPAS-B2 is a balloon-borne limb-emission sounder for atmospheric research. The heart of the instrument is a Fourier spectrometer that covers the mid-infrared spectral range (4-14 microns) and operates at cryogenic temperatures. Essential for this application is the sophisticated line-of-sight stabilization system, which is based on an inertial navigation system and is supplemented with an additional star reference system. The major scientific benefit of the instrument is the simultaneous detection of complete trace gas families in the stratosphere without restrictions concerning the time of day and viewing directions. The specifications, the design considerations, the actual realization of the instrument, and the results of characterization measurements that have been performed are described.