Bench-scale and pilot plant preparation of chemically modified polyester resins

The laboratory preparation procedure of a recently developed unsaturated polyester resin was followed to prepare the resin on a large scale (10- and 200-L pilot plant reactors). The process heating rate, reaction temperature, and agitator tip speed were kept constant on scale-up. The resin was successfully reproduced and its properties were unchanged upon scale-up. The effects of reaction temperature and inert gas flow rate on the polyesterification reaction rate were investigated. It was found that a 10°C increase in temperature or a 50% increase in the gas flow rate results in a 50% increase in the reaction rate.     

Stimuli-responsive releasing of gold nanoparticles and liposomes from aptamer-functionalized hydrogels

Controlled release of therapeutic agents is important for improving drug efficacy and reducing toxicity. Recently, hydrogels have been used for controlled release applications. While the majority of the previous work focused on releasing the cargo in response to physical stimuli such as temperature, light, electric field, and pH, we aim to trigger cargo release in the presence of small metabolites. In our system a DNA aptamer that can bind to adenosine, AMP, and ATP was used as a linker to attach either DNA-functionalized gold nanoparticles or liposomes to DNA-functionalized hydrogels. In the presence of the metabolite, both the nanoparticle and liposome cargos were released. The effect of salt, temperature, target concentration, and drying has been systematically studied. Interestingly, we found that the gel can be completely dried while retaining the DNA linkages and adenosine induced release was still achieved after rehydration. Our work demonstrates that aptamers can be used to control the release of drugs and other materials attached to hydrogels.     

Piezoelectric micromachined ultrasonic transducers: modeling the influence of structural parameters on device performance

Piezoelectric micromachined ultrasonic transducers (pMUTs), a potential alternative for conventional one-dimensional phased array ultrasonic transducers, were investigated. We used a modeling approach to study the performance of lead zirconate titanate (PZT)-driven pMUTs for the frequency range of 2-10 MHz, optimized for maximum coupling coefficient, as a function of device design. Using original tools designed for the purpose, a comprehensive build-test finite element model was developed to predict and measure the device performance. In particular, the model estimates the device coupling coefficient and the acoustic impedance, besides the readily extractable resonance frequency and bandwidth. To validate the model, a prototype device was built and tested, showing good agreement between the model predictions and experimental results. Modeling results indicate that the coupling coefficient is significantly affected by silicon membrane, PZT, and top electrode thickness as well as the top electrode design. Results also indicate considerable flexibility in maximizing the coupling coefficient while maintaining the device acoustic impedance at a level matching that of the human body. The bandwidth proved to be superior to that of conventional transducers, reaching 102% in some cases.     

An efficient weighted trust‐based malicious node detection scheme for wireless sensor networks

The aim of wireless sensor networks (WSNs) is to gather sensor data from a monitored environment. However, the collected or reported information might be falsified by faults or malicious nodes. Hence, identifying malicious nodes in an effective and timely manner is essential for the network to function properly and reliably. Maliciously behaving nodes are usually detected and isolated by reputation and trust‐based schemes before they can damage the network. In this paper, we propose an efficient weighted trust‐based malicious node detection (WT‐MND) scheme that can detect malicious nodes in a clustered WSN. The node behaviors are realistically treated by accounting for false‐positive and false‐negative instances. The simulation results confirm the timely identification and isolation of maliciously behaving nodes by the WT‐MND scheme. The effectiveness of the proposed scheme is afforded by the adaptive trust‐update process, which implicitly performs trust recovery of temporarily malfunctioning nodes and computes a different trust‐update factor for each node depending on its behavior. The proposed scheme is more effective and scalable than the related schemes in the literature, as evidenced by its higher detection ratio (DR) and lower misdetection ratio (MDR), which only slightly vary with the network's size. Moreover, the scheme sustains its efficient characteristics without significant power consumption overheads.     

Recycled poly(ethylene terephthalate) chain extension by a reactive extrusion process

A commercial‐scale reactive extrusion processing system for recycled poly(ethylene terephthalate) (PET) flakes with an added chain extender, pyromellitic dianhydride (PMDA), was investigated. The PMDA concentration was varied with the intention of reaching a higher recycled PET intrinsic viscosity ([η]). The effect of changing the extruder residence time on the system's stability and the recycled PET [η] was also investigated. Reactive extruded PET with a PMDA concentration up to 0.3 wt% was found to have a higher [η] and lower carboxyl content than recycled PET processed in a normal extrusion system. A shift in [η] of about 0.18 dl/g was obtained with a 0.3 wt% PMDA concentration. A PMDA concentration above 0.3 wt% produced chemical, thermal and hydrodynamic instability in the system, causing crosslinking reactions and gel formation. The reactive extrusion system was stable at low residence time (45 s) and moderate (0.15 wt%) PMDA concentration; however, using 0.2 wt% PMDA produced higher reactive extruded recycled PET [η] with lower carboxyl content than other PMDA concentration levels examined. Residence times higher than 45 s produced higher reactive extruded recycled PET [η]. Reactive extruded recycled PET was also tested for mechanical properties. Polym. Eng. Sci. 44:1579–1587, 2004. © 2004 Society of Plastics Engineers.     

Spectral element method for stability analysis of milling processes with discontinuous time-periodicity

This paper presents an application of the spectral element method for the stability analysis of regenerative machine tool chatter models in milling operations. An extension of the spectral element method is introduced in order to handle the discontinuities in the cutting force in an efficient way. The efficiency of the method is demonstrated on some well-known machine tool chatter models taken from the literature. Efficiency is characterized by the computational time, the convergence of the stability boundaries, and the convergence of critical characteristic multipliers. Results show that compared to the most widespread methods in machining literature, the spectral element method provides significant improvements in computational time while maintaining high accuracy levels.     

Theoretical modeling and equivalent electric circuit of a bimorph piezoelectric micromachined ultrasonic transducer

An electric circuit model for a circular bimorph piezoelectric micromachined ultrasonic transducer (PMUT) was developed for the first time. The model was made up of an electric mesh, which was coupled to a mechanical mesh via a transformer element. The bimorph PMUT consisted of two piezoelectric layers of the same material, having equal thicknesses, and sandwiched between three thin electrodes. The piezoelectric layers, having the same poling axis, were biased with electric potentials of the same magnitude but opposite polarity. The strain mismatches between the two layers created by the converse piezoelectric effect caused the membrane to vibrate and, hence, transmit a pressure wave. Upon receiving the echo of the acoustic wave, the membrane deformation led to the generation of electric charges as a result of the direct piezoelectric phenomenon. The membrane angular velocity and electric current were related to the applied electric field, the impinging acoustic pressure, and the moment at the edge of the membrane using two canonical equations. The transduction coefficients from the electrical to the mechanical domain and vice-versa were shown to be bilateral and the system was shown to be reversible. The circuit parameters of the derived model were extracted, including the transformer ratio, the clamped electric impedance, the spring-softening impedance, and the open-circuit mechanical impedance. The theoretical model was fully examined by generating the electrical input impedance and average plate displacement curves versus frequency under both air and water loading conditions. A PMUT composed of piezoelectric material with a lossy dielectric was also investigated and the maximum possible electroacoustical conversion efficiency was calculated.     

Lack of predictive control in lifting series of virtual objects by individuals with diplegic cerebral palsy

To date, research on the motor control of hand function in cerebral palsy has focused on children with hemiplegia, although many persons with diplegic cerebral palsy (dCP) have asymmetrically decreased hand function. We explored the predictive capabilities of the motor system in a simple motor task of lifting a series of virtual objects for five persons with spastic dCP and five age-matched controls. When a person lifts an object, s/he uses an expectation of the weight of the object to generate a motor command. We asked the study subjects to lift a series of increasing weights and determined whether they extrapolated from past experience to predict the next weight in the series, even though that weight had never been experienced. Planning of precision grasp was assessed by measurement of the grip force at the beginning of the lifting task and by estimating the motor command. Execution of precision grasp was assessed by measurement of the time interval between the onset of grip and the onset of movement. We found that persons with dCP demonstrated a lack of predictive feed-forward control in their lifting movements: they exhibited a significantly longer time between onset of grip and onset of movement than the control subjects and they did not predict the weight of the next object in the lifting task. In addition, for subjects with dCP, the time between the onset of grip and the onset of movement of the dominant hand correlated strongly with the outcome of a hand function test. We postulate that a higher-order motor planning deficit in addition to execution deficit are evident in the subjects with spastic diplegic.     

Dynamic voltage scaling for series hybrid amplifiers

We present an optimization of the voltage scaling algorithm in low power audio class-G amplifier for headphones application to allow longer playback time. The optimization approach minimizes the voltage difference between the internal audio amplifier power supply and its output signal over a large range of operating conditions. The modeling is based on a behavioral model enabling accurate and rapid evaluation of efficiency and audio quality with realistic input stimuli. The model validated in practice is used to optimize the voltage scaling using only few power supply levels. Thanks to a global search algorithm followed by a local one, the optimization gives the better parameters for voltage scaling algorithm while keeping a good audio quality. The proposed configuration increases the efficiency up to 48% at nominal operation.     

Supercritical Fluid Extraction and Chromatography of Lipids in Bilberry

A supercritical fluid extraction (SFE) method has been developed for the extraction of lipids in bilberry. Experimental design was used to optimize pressure, temperature and extraction time using CO₂ as solvent. Best SFE condition for total lipids was 450 bar, 60 °C and 45 min. The SFE method was compared to conventional Bligh & Dyer (B&D) extraction. The amount of fatty acid methyl esters (FAME) was found to be 4.84 ± 0.06 mg and 4.564 ± 0.003 mg per g of the freeze‐dried bilberry sample for the developed SFE and B&D methods, respectively, while the amount of total lipids was found to be 54.40 ± 6.06 mg and 65.70 ± 0.67 mg per g of sample for SFE and B&D, respectively. This discrepancy between FAME and total lipids could be explained by the presence of wax esters, sterol esters, carotenoids and phospholipids, as determined by supercritical fluid chromatography.