Effects of Xanthine Oxidase Inhibitors on Purine Catabolism

A method is described for the determination of the ability of a number of pyrazolo(3,4-d) pyrimidines and purines, which are xanthine oxidase inhibitors in vitro, to inhibit purine catabolism in the mouse. This method is based on the amount of oxypurines (hypoxanthine + xanthine) excreted in the urine during the first 5 hours after drug administration. The in vivo activity often did nut correlate with the inhibitory activity in vitro. The most active inhibitor in vivo was 4-hydroxypyrazolo(3,4-d)-pyrimidine (allopurinol).     

The Thermocatalytic Cracking Process for the Production of Light Olefins and Transportation Fuels from Gas Oils

The thermocatalytic cracking (TCC) process, which can selectively produce light olefins (mostly, ethylene and propylene for the petrochemical industry) and transportation fuels (gasoline and diesel fuel), combines the effects of thermal and catalytic cracking reactions. The TCC catalysts consist mainly of mixed metal oxides supported on a high-surface area – thermally stabilized alumina. The best TCC catalyst formulation includes a co-catalyst, which provides the main catalyst component with active hydrogen species formed from hydrogen and other hydrocarbons, particularly methane, produced mainly by thermal cracking. The interparticular interactions of these hydrogen spilt-over species can occur because these species can be easily transferred from one particle to the other through the newly formed pore connections     

A new approach to aldehydic dextrans

Summary 4-carboxybenzaldehyde as well as 3- and 4-hydroxybenzaldehyde can form adducts with dextran or its derivatives. Few easy reaction steps are necessary and even if moderate yields of aldehyde are obtained, the aldehydic dextrans thus prepared are suitable for use as drug carrying systems.Abbreviations Dx-OH dextran - Dx-CHP chlorohydroxypropyl dextran - Dx-NHP aminohydroxypropyl dextran - 4-CBA 4-carboxybenzaldehyde - 3-HBA 3-hydroxybenzaldehyde - 4-HBA 4-hydroxybenzaldehyde - EDCI 1-ethyl-3-(3-dimethyl-aminopropyl) carbodiimide hydrochloride - glu glucose unit     

Hydras and IPFS: a decentralised playground for malware

International Journal of Information Security - Modern malware can take various forms and has reached a very high level of sophistication in terms of its penetration, persistence, communication and...     

Composite corporate traveling‐wave power dividers for slot array waveguide antennas

A composite corporate traveling‐wave power divider is presented. The single‐layer structure is composed of three parts: two interdigital traveling‐wave subsections combined with a power splitter. An iterative design technique is described in which the divider is split into a number of basic blocks. Large‐scaled networks are then easily designed because the whole structure does not need to be simulated. A method to take into account the insertion losses is also proposed and bandwidth enhancement is discussed, which is done by increasing the number of corporate layers. Experimental results are also shown for a 1:4 subsection. It provides equal output power with 0.5 dB of insertion loss. The phase‐shift between output ports is close to the specifications of ?150° at 30 GHz, with an error of less than 2°. It is also shown that this topology is well suited for frequency scanning antenna. © 2008 Wiley Periodicals, Inc. Int J RF and Microwave CAE, 2009.     

Conditions for Set Agreement with an Application to Synchronous Systems

The k-set agreement problem is a generalization of the consensus problem:considering a system made up of n processes where each process proposes a value,each non-faulty process has to decide a value such that a decided value is a proposed value,and no more than k different values are decided.While this problem cannot be solved in an asynchronous system prone to t process crashes when t≥k,it can always be solved in a synchronous system;(?)+1 is then a lower bound on the number of rounds(consecutive commun...     

A query-based approach for test selection in diagnosis

Test selection in diagnosis is a procedure suggesting tests to be executed when trying to answer the query “What is the diagnosis for this problem?”. However, other queries, such as “Is h the diagnosis for this problem?”, are relevant as they can involve faster test selection algorithms and they can result in a lower test execution cost. Usually, a one step lookahead entropy minimization strategy is adopted to implement the test selection procedure. However, we show that this strategy can be arbitrarily bad and therefore, it is important to consider several strategies to solve a query. Each strategy taking a different position in the tradeoff computation time vs test execution cost. In this paper, we consider a query-based approach where test selection is justified and driven by a user’s specific query. We also study different strategies, optimal and approximate, for test selection. Finally, we illustrate how the operating system discovery (OSD) problem can be solved using a diagnosis framework and how it benefits from a query-based approach.