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排序方式: 共有473条查询结果,搜索用时 15 毫秒
51.
Sven H. Rouschop Samantha J. Snow Urmila P. Kodavanti Marie-Jos Drittij Lou M. Maas Antoon Opperhuizen Frederik J. van Schooten Alexander H. Remels Roger W. Godschalk 《International journal of molecular sciences》2021,22(14)
Previous research has shown that a perinatal obesogenic, high-fat diet (HFD) is able to exacerbate ozone-induced adverse effects on lung function, injury, and inflammation in offspring, and it has been suggested that mitochondrial dysfunction is implicated herein. The aim of this study was to investigate whether a perinatal obesogenic HFD affects ozone-induced changes in offspring pulmonary oxidant status and the molecular control of mitochondrial function. For this purpose, female Long-Evans rats were fed a control diet or HFD before and during gestation, and during lactation, after which the offspring were acutely exposed to filtered air or ozone at a young-adult age (forty days). Directly following this exposure, the offspring lungs were examined for markers related to oxidative stress; oxidative phosphorylation; and mitochondrial fusion, fission, biogenesis, and mitophagy. Acute ozone exposure significantly increased pulmonary oxidant status and upregulated the molecular machinery that controls receptor-mediated mitophagy. In female offspring, a perinatal HFD exacerbated these responses, whereas in male offspring, responses were similar for both diet groups. The expression of the genes and proteins involved in oxidative phosphorylation and mitochondrial biogenesis, fusion, and fission was not affected by ozone exposure or perinatal HFD. These findings suggest that a perinatal HFD influences ozone-induced responses on pulmonary oxidant status and the molecular control of mitophagy in female rat offspring. 相似文献
52.
Dr. Beatriz C. Ma Dr. Lucas Caire da Silva Dr. Seong-Min Jo Dr. Frederik R. Wurm Dr. Markus B. Bannwarth Dr. Kai A. I. Zhang Prof. Dr. Kai Sundmacher Prof. Dr. Katharina Landfester 《Chembiochem : a European journal of chemical biology》2019,20(20):2593-2596
The regeneration of enzymatic cofactors by cell-free synthetic modules is a key step towards producing a purely synthetic cell. Herein, we demonstrate the regeneration of the enzyme cofactor NAD+ by photo-oxidation of NADH under visible-light irradiation by using metal-free conjugated polymer nanoparticles. Encapsulation of the light-active nanoparticles in the lumen of polymeric vesicles produced a fully organic module able to regenerate NAD+ in an enzyme-free system. The polymer compartment conferred physical and chemical autonomy to the module, allowing the regeneration of NAD+ to occur efficiently, even in harsh chemical environments. Moreover, we show that regeneration of NAD+ by the photocatalyst nanoparticles can oxidize a model substrate, in conjunction with the enzyme glycerol dehydrogenase. To ensure the longevity of the enzyme, we immobilized it within a protective silica matrix; this yielded enzymatic silica nanoparticles with enhanced long-term performance and compatibility with the NAD+-regeneration system. 相似文献
53.
Frederik C. Krebs Kristian O. Sylvester‐Hvid Mikkel Jrgensen 《Progress in Photovoltaics: Research and Applications》2011,19(1):97-112
A compact platform for testing solar cells is presented. The light source comprises a multi‐wavelength high‐power LED (light emitting diode) array allowing the homogenous illumination of small laboratory solar cell devices (substrate size 50 × 25 mm) within the 390–940 nm wavelength range. The spectrum can be synthesized by independent tuning of the 18 different wavelengths to mimic AM1.5G as well as various indoor lamp spectra. The intensity can be controlled with a 214‐bit accuracy and intensities up to 3 suns are possible with an approximate AM1.5G spectral distribution. For several wavelengths intensities up to 10 suns is possible, and for a few wavelengths up to 30 suns can be reached. The setup is equipped with reference diodes and an optical fibre coupling enabling calibration, monitoring and control of the light impinging on the sample. Through a computer controlled interface, it is possible to perform all the commonly employed measurements on the solar cell at very high speed without moving the sample. In particular, the LED‐based illumination system provides an alternative to light‐biased incident photon‐to‐current efficiency measurement to be performed which we demonstrate. Both top and bottom contact is possible and the atmosphere can be controlled around the sample during measurements. The setup was developed for the field of polymer and organic solar cells with particular emphasis on enabling different laboratories to perform measurements in the same manner and obtain a common basis for comparing data. The use of the platform is demonstrated using a standard P3HT:PCBM polymer solar cell but is generally applicable to any solar cell technology with a spectral response in the 390–950 nm region. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
54.
Duparc Estelle Möller Frederik Jussen Ilka Stachon Maleen Algac Sükran Otto Boris 《Electronic Markets》2022,32(2):727-745
Electronic Markets - The open-source paradigm offers a plethora of opportunities for innovative business models (BMs) as the underlying codebase of the technology is accessible and extendable by... 相似文献
55.
Forster Yannick Hergeth Sebastian Naujoks Frederik Krems Josef F. Keinath Andreas 《Cognition, Technology & Work》2020,22(4):703-720
Cognition, Technology & Work - For a successful market introduction of Level 3 Automated Driving Systems (L3 ADS), a careful evaluation of human–machine interfaces (HMIs) is necessary.... 相似文献
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About 80% of all fire fatalities in Germany occur because of fires in homes. It has been known for some time that modern materials (synonym for materials consisting mostly of synthetic polymers) tend to burn differently from older materials (synonym for materials consisting mostly of fibrous cellulosic substances) and it has been acknowledged that the amount of combustible plastics in homes has increased significantly over the last decades. To investigate the influence of modern furniture and ventilation conditions of fires in homes, a series of four large‐scale tests in two living rooms (LRs) with adjacent rooms (ARs) was performed by BAM and the Frankfurt fire service. Two LRs, one with older furniture and one with modern furniture, were tested twice each. Each test started with the ignition of a paper cushion on an upholstered chair. The influence of modern materials on the fire development was investigated, as well as the influence of the ventilation on the fire development. In all settings, an upholstered chair was the first burning item. Results of the test series show that fires in rooms with modern furniture develop faster than fires in rooms with older furniture. This is true for temperature development in the rooms as well as for smoke production. 相似文献
58.
Johannes Hintsch Frederik Kramer Klaus Turowski 《Information Systems and E-Business Management》2018,16(3):649-682
In manufacturing, substantial efficiency gains have been achieved through industrialization. Key concepts of industrialization include standardization, automation, and modularization. Transferring these to IT service production promises increased efficiency. ERP systems apply such concepts and have been an integrating tool for making production for manufacturers more efficient. However, previous research has considered ERP systems for IT service providers either very broadly or only from a business or technical perspective. This article investigates how to apply the ERP system concept comprehensively to a specific type of IT service provider. To this end, application services are prescribed as being composed of three types of configuration models. This helps to achieve a composition of (IT) application services that is comparable to physical parts, and it further supports their management and automated production within an ERP system. An information system architecture with the ERP system at its core is presented. It supports application service production. All relevant service lifecycle phases are considered and a consistent domain model is provided that connects business and technical layer entities. Targeted companies can improve their application service production in terms of quality and efficiency by leveraging this novel automation- and model-based approach. 相似文献
59.
Effect of process parameters on the adhesion strength in two‐component injection molding of thermoset rubbers and thermoplastics
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Gert‐Jan Bex Wim Six Brittany Laing Jozefien De Keyzer Frederik Desplentere Albert Van Bael 《应用聚合物科学杂志》2018,135(29)
Recently, a novel two‐component injection molding process has been developed for combining thermoplastics with thermoset rubbers. This process is of interest for example when thermoplastic parts include seals which are usually produced out of thermoset rubber. The present study evaluates the influence of different process parameters on the bond strength by means of a half factorial experimental design. The considered process parameters are the mold temperature at the interface, the injection temperature, the injection speed, the holding pressure, and the initial roughness of the thermoplastic part at the later interface. The study indicates a large influence of the mold temperature at the interface. Furthermore, the holding pressure only affects the adhesion strength when it is set too low or when the holding time is too short. The other process parameters have no significant effect on the adhesion strength. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135, 46495. 相似文献
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