Stability analysis of closed-loop water system

Aiming at closed-loop water system, by the method that shutting certain subcircuit, and solving the piping network, computing flow deviation of other subcircuits, then analyzing the rules of variation of stability with various factors, following conclusions are obtained: When reducing the resistance in main pipes, increasing resistance of subcircuits, system stability can be improved. Centralized regulation by changing power has no influence on system stability; centralized regulation by changing resistances will decrease system stability. Pump characteristics curve influences system stability, stability of the flat characteristic is superior to the steep one. For direct return system (DRS), the stability of subcircuit which is farthest from the heat source is the worst. For reverse return system (RRS), the stability of subcircuit in the middle of the pipe-network has the worst stability. Overall, stability of RRS is inferior to that of DRS.     

一组采用四星形接线10kV TV故障原因分析

介绍了10kV系统中一组采用四星形接线的TV发生爆炸经过,通过分析其爆炸的原因提出了解决措施.     

Corrosion behaviour of Al1.3CrFeNi chemically complex alloy

In this study, corrosion behaviour of double-phase Al_1.3CrFeNi chemically complex alloy was investigated, including hot corrosion and electrochemical corrosion. Hot corrosion behaviour of Al_1.3CrFeNi alloy was explored in molten 75 wt-% Na₂SO₄?+?25 wt-% NaCl salt. The result revealed that the corrosion kinetic curve of Al_1.3CrFeNi alloy followed the exponential rate rule through mass loss measurement. In addition, it prevented that the formed corrosion layer had obvious stratification including external granular Al₂O₃ and inner porous Cr₂O₃ when corrosion time was up to 100?h. Besides, it should be noted that the Al_1.3CrFeNi alloy was sensitive to the molten salt containing chlorine, which makes the alloy surface leave voids and bring about acceleration of corrosion. Meanwhile, electrochemical corrosion resistance of Al_1.3CrFeNi alloy in NaCl solution with different concentrations (0.6, 1.0 and 2.0?mol?L^?1) was investigated at room temperature. The results revealed that Al_1.3CrFeNi alloy showed superior corrosion resistance in NaCl solution due to the existence of Al and Cr which aid the formation of protective oxide layer.     

Distortions and tensile properties of 15-5PH steel cylinders with EBW and heat treatment

15-5PH steel is one of the martensitic precipitation-hardened stainless steels, which is extensively applied in the aero shafts, and electron beam welding is a significant procedure to manufacture the parts. To verify the dimension accuracies and properties, EBW with oscillation was employed on the cylinders of 15-5PH steel. The welding distortions were measured, and the microstructures and tensile properties of the joints were investigated. The weld appearances of the cylinders were smooth, and the morphology was parallel. After EBW, the shrinkages of the cylinders were above ?0.22?mm, and the welding distortions were ?0.66 to ?1.1‰, and the straightnesses were less than 1‰ due to the distortions. The martensites and a few austenites were in the welds of the cylinders after heat treatment, and the microhardnesses in the welds were 445 HV0.2, which were bigger and more homogeneous than those of the as-welded. The tensile strength and yield strength of the joints were respectively 1300 and 1150?MPa, which were higher than those of the as-welded joints, and the elongation rate of the joints was 10%. The microstructures and properties of the cylinders conformed to the aero shafts, which was attributed to the microstructure transformation with oscillation EBW and heat treatment.     

Kinome-Wide Profiling Identifies Human WNK3 as a Target of Cajanin Stilbene Acid from Cajanus cajan (L.) Millsp.

Pigeon Pea (Cajanus cajan (L.) Millsp.) is a common food crop used in many parts of the world for nutritional purposes. One of its chemical constituents is cajanin stilbene acid (CSA), which exerts anticancer activity in vitro and in vivo. In an effort to identify molecular targets of CSA, we performed a kinome-wide approach based on the measurement of the enzymatic activities of 252 human kinases. The serine-threonine kinase WNK3 (also known as protein kinase lysine-deficient 3) was identified as the most promising target of CSA with the strongest enzymatic activity inhibition in vitro and the highest binding affinity in molecular docking in silico. The lowest binding affinity and the predicted binding constant pKi of CSA (−9.65 kcal/mol and 0.084 µM) were comparable or even better than those of the known WNK3 inhibitor PP-121 (−9.42 kcal/mol and 0.123 µM). The statistically significant association between WNK3 mRNA expression and cellular responsiveness to several clinically established anticancer drugs in a panel of 60 tumor cell lines and the prognostic value of WNK3 mRNA expression in sarcoma biopsies for the survival time of 230 patients can be taken as clues that CSA-based inhibition of WNK3 may improve treatment outcomes of cancer patients and that CSA may serve as a valuable supplement to the currently used combination therapy protocols in oncology.     

Creation and control of high-dimensional multi-partite classically entangled light

Vector beams, non-separable in spatial mode and polarisation, have emerged as enabling tools in many diverse applications, from communication to imaging. This a...     

The Regulatory Role of H19/miR-181a/ATG5 Signaling in Perinatal Nicotine Exposure-Induced Development of Neonatal Brain Hypoxic-Ischemic Sensitive Phenotype

Nicotine exposure either from maternal cigarette smoking or e-cigarette vaping is one of the most common risk factors for neurodevelopmental disease in offspring. Previous studies revealed that perinatal nicotine exposure programs a sensitive phenotype to neonatal hypoxic-ischemic encephalopathy (HIE) in postnatal life, yet the underlying mechanisms remain undetermined. The goal of the present study was to determine the regulatory role of H19/miR-181a/ATG5 signaling in perinatal nicotine exposure-induced development of neonatal brain hypoxic-ischemic sensitive phenotype. Nicotine was administered to pregnant rats via subcutaneous osmotic minipumps. All experiments were conducted in offspring pups at postnatal day 9 (P9). Perinatal nicotine exposure significantly enhanced expression of miR-181a but attenuated autophagy-related protein 5 (ATG5) mRNA and protein levels in neonatal brains. Of interest, miR-181a mimicking administration in the absence of nicotine exposure also produced dose-dependent increased hypoxia/ischemia (H/I)-induced brain injury associated with a decreased ATG5 expression, closely resembling perinatal nicotine exposure-mediated effects. Locked nucleic acid (LNA)-miR-181a antisense reversed perinatal nicotine-mediated increase in H/I-induced brain injury and normalized aberrant ATG5 expression. In addition, nicotine exposure attenuated a long non-coding RNA (lncRNA) H19 expression level. Knockdown of H19 via siRNA increased the miR-181a level and enhanced H/I-induced neonatal brain injury. In conclusion, the present findings provide a novel mechanism that aberrant alteration of the H19/miR-181a/AGT5 axis plays a vital role in perinatal nicotine exposure-mediated ischemia-sensitive phenotype in offspring and suggests promising molecular targets for intervention and rescuing nicotine-induced adverse programming effects in offspring.     

车灯座注塑模具设计

通过对车灯座注塑模具的设计,阐述了模具浇注系统的设计方法,旨在降低模具的复杂程度和制造成本;详细介绍了组合式型腔、型芯的结构设计及模具的制造方法。     

The design of the J-type neutron flux distribution measurement system

This paper introduces the design of a J-type aeroball system that the tube penetrates the lateral wall of reactor pressurized vessel (RPV), then immediately goes down to the vessel bottom and then goes up through the lower core support plate into the reactor core. Some experimental results related to gas flowing within a thin tube are presented in the paper, such as the gas friction drag coefficient on the ball’s way and etc. From theoretical and experimental viewpoints, the feasibility of the system is proved in pneumatic holding-up and β measurement aspects. In order to ensure an enough ratio of signal to noise, the maximum distance between two measuring points in water reactors is given. The paper gives out the measuring number per two-assemblies width N_i=Int(n_i/2+0.51), which is the accuracy relation between the number of fuel assembly and the minimum one of measuring point to only reconstruct 2D neutron flux distribution completely by the measured data.     

交变磁处理对金刚石锯片切割性能的影响

选用不同的工艺参数在交变磁场中对金刚石锯片通磁处理,通过对磁处理试件和未磁处理试件的对比切割试验,研究了交变磁处理对金刚石锯片切割性能的影响.研究结果表明:交变磁处理提高了胎体对金刚石的机械把持力,数据统计显示,磁处理锯片金刚石颗粒的脱落率低,参与切割的金刚石数目多,金刚石的有效利用率得到提高;从切割效果来看,交变磁场能够有效提高金刚石锯片的切割性能,但磁处理温度条件对锯片的切割性能有一定的影响;试验优选的磁处理工艺条件为:300 ℃、50 Hz、1 T、60 min,在该工艺条件下,锯片的使用寿命提高46.3%,切割速度提高13.1%;断口组织形貌分析显示,交变磁处理后试件胎体的组织晶粒细小,晶粒细化是金刚石锯片切割性能提高的根本原因.