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排序方式: 共有338条查询结果,搜索用时 31 毫秒
241.
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Hiroyuki Mizukami Shu-ichi Saitoh Hirofumi Machii Shinya Yamada Yasuto Hoshino Tomofumi Misaka Akihito Ishigami Yasuchika Takeishi 《International journal of molecular sciences》2013,14(5):9408-9423
Senescence marker protein-30 (SMP30) decreases with aging. Mice with SMP30 deficiency, a model of aging, have a short lifespan with increased oxidant stress. To elucidate SMP30’s effect on coronary circulation derived from myocytes, we measured the changes in the diameter of isolated coronary arterioles in wild-type (WT) mice exposed to supernatant collected from isolated paced cardiac myocytes from SMP30 KO or WT mice. Pacing increased hydrogen peroxide in myocytes, and hydrogen peroxide was greater in SMP30 KO myocytes compared to WT myocytes. Antimycin enhanced and FCCP (oxidative phosphorylation uncoupler in mitochondria) decreased superoxide production in both groups. Addition of supernatant from stimulated myocytes, either SMP30 KO or WT, caused vasodilation. The degree of the vasodilation response to supernatant was smaller in SMP30 KO mice compared to WT mice. Administration of catalase to arterioles eliminated vasodilation in myocyte supernatant of WT mice and converted vasodilation to vasoconstriction in myocyte supernatant of SMP30 KO mice. This vasoconstriction was eliminated by olmesartan, an angiotensin II receptor antagonist. Thus, SMP30 deficiency combined with oxidant stress increases angiotensin and hydrogen peroxide release from cardiac myocytes. SMP30 plays an important role in the regulation of coronary vascular tone by myocardium. 相似文献
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An amino‐functional copolymer [N,N,‐dimethyl‐1,3‐propanediamine (MCD)] developed in our laboratory was blended with carbon black (CB/MCD composite) and its electrical responses to toluene vapor at low concentrations were measured at 30°C. When exposed to 200 ppm of toluene vapor, the CB/MCD sensor responded at S = 0.04 (S was obtained by dividing the relative change in the resistance of the sensor upon exposure to toluene vapor by the baseline resistance), demonstrating its ability to detect toluene vapor at low concentrations. The response was affected by humidity in the atmosphere due to the hydrophilic nature of MCD film; however, the behavior was reproducible before and after exposure of the sensor to the humid atmosphere. In addition, in 10 consecutive sorbing/desorbing cycles, it was confirmed that the changes in the resistance of the CB/MCD sensor were reproducible. These favorable sensing characteristics were attributed to vapor sorption behavior arising from the glassy and loosely crosslinked nature of MCD and explained by the dual‐sorption model. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013 相似文献
245.
Masaaki Tabuchi Hiromichi Hongo Fujio Abe 《Metallurgical and Materials Transactions A》2014,45(11):5068-5075
The commercialization of a 973 K (700 °C) class pulverized coal power system, advanced ultra-supercritical (A-USC) pressure power generation, is the target of an ongoing research project initiated in Japan in 2008. In the A-USC boiler, Ni or Ni-Fe base alloys are used for high-temperature parts at 923 K to 973 K (650 °C to 700 °C), and advanced high-Cr ferritic steels are planned to be used at temperatures lower than 923 K (650 °C). In the dissimilar welds between Ni base alloys and high-Cr ferritic steels, Type IV failure in the heat-affected zone (HAZ) is a concern. Thus, the high B-9Cr steel developed at the National Institute for Materials Science, which has improved creep strength in weldments, is a candidate material for the Japanese A-USC boiler. In the present study, creep tests were conducted on the dissimilar welded joints between Ni base alloys and high B-9Cr steels. Microstructures and creep damage in the dissimilar welded joints were investigated. In the HAZ of the high B-9Cr steels, fine-grained microstructures were not formed and the grain size of the base metal was retained. Consequently, the creep rupture life of the dissimilar welded joints using high B-9Cr steel was 5 to 10 times longer than that of the conventional 9Cr steel welded joints at 923 K (650 °C). 相似文献
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The National Institute of Standards and Technology (NIST) and the Center for Better Living have formed a collaboration to assess the performance and failure mechanisms of gypsum wall assemblies under real fires/furnace conditions. These measurements are being used to compile an experimental database necessary to validate models that could be used to predict their performance and ultimate failure under various design fires. A critical component of the database is thermal property data of gypsum board. The present paper describes the results of an effort to quantify thermal properties of gypsum board. The thermal conductivity specific heat mass loss and linear contraction for gypsum board types widely used in the U.S.A. and Japan were measured both at room temperature and at elevated temperatures. The gypsum board types tested include Type X and Type C from the U.S.A. and Type R and Type F from Japan. Results indicate that the difference in thermal properties of all gypsum board samples tested in the present study is not significant particularly at elevated temperatures. A large difference in linear contraction among gypsum board samples was observed at elevated temperatures, implying a significant difference in mechanical behavior at fire temperatures. The experimental data set provides valuable information that can be used to model the behavior of gypsum board at elevated temperatures. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
248.
Shin Mizukami Dr. Shuji Watanabe Kazuya Kikuchi Prof. 《Chembiochem : a European journal of chemical biology》2009,10(9):1465-1468
A novel design strategy for fluorescent probes based on a pKa switching mechanism was developed. Using this strategy, we developed ratiometric probes for the detection of acid phosphatase activity.
249.
Sobahan Mia Shota Mizukami Ryusei Fukuda Shigeki Morita Nobuyoshi Ohno 《Journal of Mechanical Science and Technology》2010,24(1):111-114
Different types of synthetic polyalphaolefin (PAO) oils and a mineral oil are considered in this study. High-pressure viscosity
test was done and pressure-viscosity coefficient was measured for all sample oils. Results showed the better performance of
PAO oils than the mineral oil. Authors also tested some other tribological properties such as low-temperature behavior, bulk
property, frictional coefficient, and wear behavior, which are important for wind turbine gear oil. Low-temperature behavior
and frictional property of PAO oils exhibited the better results. Study also showed that the prediction of low-temperature
fluidity is possible using the sound velocity in the oil. Finally, the presence of polymethakrylate (PMA) absorbent in PAO
oil exposed comparatively better results among all PAO oils. 相似文献
250.
Mizukami M. Hirohata N. Iseki T. Ohtawara K. Tada T. Yagyu S. Abe T. Suzuki T. Fujisaki Y. Inoue Y. Tokito S. Kurita T. 《Electron Device Letters, IEEE》2006,27(4):249-251
Active matrix organic-light-emitting-diode (AM OLED) panels, driven by organic thin-film transistors (OTFT), have been successfully fabricated on a flexible plastic substrate. The pixel circuit consists of two bottom-contact pentacene OTFTs working as switching and driving transistors. The panel has 16 /spl times/ 16 pixels, each of which have an OLED using a phosphorescent material with an emission efficiency of 30 cd/A. A tantalum oxide (Ta/sub 2/O/sub 5/) film with a dielectric constant of 24, prepared by the anodization of Tantalum (Ta), was used as the gate insulator of the OTFTs. The passivation layer on the OTFTs was formed by a layer of silicon dioxide (SiO/sub 2/) and two layers of polyvinyl alcohol. Using OTFTs with a Ta/sub 2/O/sub 5/ gate insulator, the authors have realized a flexible active matrix OLED panel driven with a low voltage of -12 V. 相似文献