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151.
Cosmin Vasilica Pricope Bogdan Ionel Tamba Gabriela Dumitrita Stanciu Magdalena Cuciureanu Anca Narcisa Neagu Ioana Creanga-Murariu Bogdan-Ionut Dobrovat Cristina Mariana Uritu Silviu Iulian Filipiuc Bianca-Mariana Pricope Teodora Alexa-Stratulat 《International journal of molecular sciences》2022,23(21)
Chronic neuropathic pain (CNP) affects around 10% of the general population and has a significant social, emotional, and economic impact. Current diagnosis techniques rely mainly on patient-reported outcomes and symptoms, which leads to significant diagnostic heterogeneity and subsequent challenges in management and assessment of outcomes. As such, it is necessary to review the approach to a pathology that occurs so frequently, with such burdensome and complex implications. Recent research has shown that imaging methods can detect subtle neuroplastic changes in the central and peripheral nervous system, which can be correlated with neuropathic symptoms and may serve as potential markers. The aim of this paper is to review available imaging methods used for diagnosing and assessing therapeutic efficacy in CNP for both the preclinical and clinical setting. Of course, further research is required to standardize and improve detection accuracy, but available data indicate that imaging is a valuable tool that can impact the management of CNP. 相似文献
152.
Elena Manaila Gabriela Craciun Ion Cosmin Calina 《International journal of molecular sciences》2023,24(1)
Being both a cause and a victim of water scarcity and nutrient deficiency, agriculture as a sustainable livelihood is dependent now on finding new suport solutions. Biodegradable hydrogels usage as soil conditioners may be one of the most effective solutions for irrigation efficiency improvement, reducing the quantity of soluble fertilizers per crop cycle and combating pathogens, due to their versatility assured by both obtaining method and properties. The first goal of the work was the obtaining by electron beam irradiation and characterization of some Sodium Alginate-g-acrylamide/acrylic Acid hydrogels, the second one being the investigation of their potential use as a soil conditioner by successive experiments of absorption and release of two different aqueous nutrient solutions. Alginate-g-acrylamide/acrylic Acid hydrogels were obtained by electron beam irradiation using the linear accelerator ALID 7 at 5.5 MeV at the irradiation doses of 5 and 6 kGy. For this were prepared monomeric solutions that contained 1 and 2% sodium alginate, acrylamide and acrylic acid in ratios of 1:1 and 1.5:1, respectively, for the obtaining of materials with hybrid properties derived from natural and synthetic components. Physical, chemical, structural and morphological characteristics of the obtained hydrogels were investigated by specific analysis using swelling, diffusion and network studies and Fourier Transform Infrared Spectroscopy and Scanning Electron Microscopy. Four successive absorption and release experiments of some synthetic and natural aqueous solutions with nutrients were performed. 相似文献
153.
Teodora Barbalata Alina I. Scarlatescu Gabriela M. Sanda Laura Toma Camelia S. Stancu Maria Dorobantu Miruna M. Micheu Anca V. Sima Loredan S. Niculescu 《International journal of molecular sciences》2022,23(17)
Myocardial infarction is one of the leading causes of death worldwide, despite numerous efforts to find efficient prognostic biomarkers and treatment targets. In the present study, we aimed to assess the potential of six microRNAs known to be involved in cardiovascular diseases, cell-free DNA (cfDNA), and mitochondrial DNA (mtDNA) circulating in plasma to be used as prognostic tools for the occurrence of unfavorable outcomes such as major adverse cardiovascular events (MACE) after acute ST-segment elevation myocardial infarction (STEMI). Fifty STEMI patients were enrolled and monitored for 6 months for the occurrence of MACE. Plasma was collected at three time points: upon admission to hospital (T0), at discharge from hospital (T1), and 6 months post-STEMI (T6). Plasma levels of miR-223-3p, miR-142-3p, miR-155-5p, miR-486-5p, miR-125a-5p, and miR-146a-5p, as well as of cfDNA and mtDNA, were measured by RT-qPCR. Results showed that the levels of all measured miRNAs, as well as of cfDNA and mtDNA, were the most increased at T1, compared to the other two time points. In the plasma of STEMI patients with MACE compared to those without MACE, we determined increased levels of miRNAs, cfDNA, and mtDNA at T1. Hence, we used the levels of all measured parameters at T1 for further statistical analysis. Statistical analysis demonstrated that all six miRNAs and cfDNA plus mtDNA levels, respectively, were associated with MACE. The minimal statistical model that could predict MACE in STEMI patients was the combination of mtDNA and miR-142-3p levels, as evidenced by ROC analysis (AUC = 0.97, p < 0.001). In conclusion, the increased plasma levels of mtDNA, along with miR-142-3p, could be used to predict unfavorable outcomes in STEMI patients. 相似文献
154.
Marcelo Ozu Juan Jos Alvear-Arias Miguel Fernandez Agustín Caviglia Antonio Pea-Pichicoi Christian Carrillo Emerson Carmona Anselmo Otero-Gonzalez Jos Antonio Garate Gabriela Amodeo Carlos Gonzalez 《International journal of molecular sciences》2022,23(20)
Aquaporins (AQPs) are small transmembrane tetrameric proteins that facilitate water, solute and gas exchange. Their presence has been extensively reported in the biological membranes of almost all living organisms. Although their discovery is much more recent than ion transport systems, different biophysical approaches have contributed to confirm that permeation through each monomer is consistent with closed and open states, introducing the term gating mechanism into the field. The study of AQPs in their native membrane or overexpressed in heterologous systems have experimentally demonstrated that water membrane permeability can be reversibly modified in response to specific modulators. For some regulation mechanisms, such as pH changes, evidence for gating is also supported by high-resolution structures of the water channel in different configurations as well as molecular dynamics simulation. Both experimental and simulation approaches sustain that the rearrangement of conserved residues contributes to occlude the cavity of the channel restricting water permeation. Interestingly, specific charged and conserved residues are present in the environment of the pore and, thus, the tetrameric structure can be subjected to alter the positions of these charges to sustain gating. Thus, is it possible to explore whether the displacement of these charges (gating current) leads to conformational changes? To our knowledge, this question has not yet been addressed at all. In this review, we intend to analyze the suitability of this proposal for the first time. 相似文献
155.
Paiva Pedro Yuri Arbs Moreno Camila Castro Smith-Miles Kate Valeriano Maria Gabriela Lorena Ana Carolina 《Machine Learning》2022,111(8):3085-3123
Machine Learning - Machine Learning studies often involve a series of computational experiments in which the predictive performance of multiple models are compared across one or more datasets. The... 相似文献
156.
Gabriela?Viale?PereiraEmail author Marie?Anne?Macadar Edimara?M.?Luciano Maurício?Gregianin?Testa 《Information Systems Frontiers》2017,19(2):213-229
By using ICT in an innovative way, governments can improve the delivery of services and interaction with stakeholders. Open data is a way to help public organizations became more open and improve interaction with stakeholders. This paper aims to identify what are the public values enhancements acquired on smart city environment that discloses open data. We propose a conceptual model to analyze the smart city initiative. We contextualized the model taking a smart city domain by analyzing three related-initiatives that comprises open data in a smart city case carried at Rio de Janeiro Operations Center (COR) in Brazil by seven deep-interviewees directly involved - from inside and outside – in this case. The findings reveal evidences that open data initiatives contribute to enhance the delivery of public value in smart city contexts. 相似文献
157.
158.
Margarida Moldão-Martins Gabriela M. Bernardo-Gil Luísa M. da Costa 《European Food Research and Technology》2002,214(3):207-211
The effects of the extraction procedure on the sensory and chemical evaluation of Thymus zygis L. aromatic extracts obtained by hydro distillation and compressed CO2 extraction were studied. Compressed CO2 extractions were performed at a temperature of 313 K and 10 and 15 MPa of pressure for 60 min. Aromatic extracts were analysed by GC and GC-MS. Sensorial analysis of the aromatic extracts incorporated into a sunflower oil was carried out by a panel of 20 trained members. The main compounds of Thymus zygis essential oil obtained by Clevenger distillation are: p-cymene (13.6%), thymol (23.8%), geraniol (18.2%), and geranyl acetate (16.3%). The compositions of supercritical extracts are quite different. The detection threshold of Thymus zygis essential oil was 0.001 mg/kg sunflower oil. The preferred level of essential oil incorporation was 0.02 mg/kg sunflower oil (P<0.05). Sensorial attributes were correlated with chemical compositions and it can be concluded that extracts with higher levels of phenols and geranyl acetate were preferred. 相似文献
159.
Karen L Cropsey Gloria D Eldridge Michael F Weaver Gabriela C Villalobos Maxine L Stitzer 《Nicotine & tobacco research》2006,8(5):653-659
Breath carbon monoxide (CO) is a convenient, widely used method for abstinence validation, with cutoffs of 8-10 ppm commonly employed. The goal of the present study was to determine an appropriate CO cutoff to differentiate nonsmokers and smokers within a large sample (N = 374) of female prisoners incarcerated at a correctional facility in Virginia. Mean age of the population was 34.5 years, 49.2% were White, and 29% had less than a high school education. Smoking prevalence was 74.1% within the prison population. Examination of CO levels versus smoking self-report using a receiver operator characteristic (ROC) analysis revealed that a CO cutoff of 3 ppm resulted in the best sensitivity (98.1%) and specificity (95.8%). Overall ROC area under the curve was 99% (95% CI = 98.2%-99.9%). This same cutoff was optimal for smoking subgroups including Black and light (<10 cigarettes/day) smokers. Results suggest that CO cutoffs higher than 3 ppm may misclassify some smokers as nonsmokers and underestimate the prevalence of smoking. 相似文献
160.
Palestri P. Barin N. Esseni D. Fiegna C. 《Electron Devices, IEEE Transactions on》2006,53(6):1443-1451
In this paper, the stability of self-consistent Monte Carlo (MC) device simulations is revised by developing a model that extends the existing ones by accounting for the effect of a carrier diffusion. Both the linear and the nonlinear Poisson schemes have been considered. The analysis of the linear Poisson scheme reveals that, consistently with the available model, the time step between two Poisson solutions must be short compared to a factor proportional to the scattering rate. On the other hand, it has been found that, contrary to the available stability models, the nonlinear Poisson scheme requires long time steps in order to provide stable simulations. For this reason, the nonlinear scheme is advantageous when considering steady-state simulations. The model predictions have been verified by comparison with MC simulations implementing both schemes. 相似文献