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151.
152.
Chen J Luo Y Hong L Ling Y Pang J Fang Y Wei K Gao X 《Journal of materials science. Materials in medicine》2011,22(3):547-555
A superior drug controlled release system capable of achieving efficient osteogenesis is in imperative demand because of limited
bone substitute tissue for the treatment of bone defect. In the present study, we investigated the potential of using poly(ε-caprolactone)–hydroxyapatite
(PCL–HA) composite microspheres as an injectable bone repair vehicle by controlled release of alendronate (AL), a medicine
that belongs to the bisphosphonates family. The PCL/HA–AL microspheres were prepared with solid/oil/water emulsion technique,
which included two processes: (1) AL was loaded on the hydroxyapatite nanoparticles; (2) the HA–AL complex was built in the
PCL matrix. The spherical PCL/HA–AL microspheres were characterized with its significantly improved encapsulation efficiency
of hydrophilic AL and better sustained release. Human bone mesenchymal stem cells (hMSCs) were cultured on the surface of
these microspheres and exhibited high proliferative profile. Specifically, in osteogenic medium, hMSCs on the surface of PCL/HA–AL
microspheres displayed superior osteogenic differentiation which was verified by alkaline phosphatase activity assay. In conclusion,
by presenting strong osteogenic commitment of hMSCs in vitro, the PCL/HA–AL microspheres have the potential to be used as
an injectable vehicle for local therapy of bone defect. 相似文献
153.
脊波导在传播电磁波的过程中伴随有能量损耗,为了研究填充介质脊波导的衰减特性,本文采用有限元法借助Matlab软件计算了TE模式下部分填充介质倒梯形对称双脊波导的衰减常数和功率容量.分析了脊波导衰减常数和功率容量与脊波导尺寸、工作频率、填充介质相对介电常数之间的关系,给出关系曲线图.这些结果将丰富现有的填充非均匀介质脊波导的数据,为填充介质脊波导的设计和优化提供有价值的依据. 相似文献
154.
Bohong Su Haitao Wu Yong Guo Huawei Gao Zhongyan Wei Yuyang Zhao Lijuan Qiu 《International journal of molecular sciences》2022,23(15)
Soybean plant height and branching affect plant architecture and yield potential in soybean. In this study, the mutant dmbn was obtained by treating the cultivar Zhongpin 661 with ethylmethane sulfonate. The dmbn mutant plants were shorter and more branched than the wild type. The genetic analysis showed that the mutant trait was controlled by a semi-dominant gene. The candidate gene was fine-mapped to a 91 kb interval on Chromosome 9 by combining BSA-seq and linkage analysis. Sequence analysis revealed that Glyma.09g193000 encoding an Aux/IAA protein (GmIAA27) was mutated from C to T in the second exon of the coding region, resulting to amino acid substitution of proline to leucine. Overexpression of the mutant type of this gene in Arabidopsis thaliana inhibited apical dominance and promoted lateral branch development. Expression analysis of GmIAA27 and auxin response genes revealed that some GH3 genes were induced. GmIAA27 relies on auxin to interact with TIR1, whereas Gmiaa27 cannot interact with TIR1 owing to the mutation in the degron motif. Identification of this unique gene that controls soybean plant height and branch development provides a basis for investigating the mechanisms regulating soybean plant architecture development. 相似文献
155.
156.
Qi Haoliang Li Sheng Gao Jianfeng Han Zhongyuan Xia Xinsong 《电子科学学刊(英文版)》2008,25(1):120-124
This letter presents a new discriminative model for Information Retrieval (IR), referred to as Ordinal Regression Model (ORM). ORM is different from most existing models in that it views IR as ordinal regression problem (i.e. ranking problem) instead of binary classification. It is noted that the task of IR is to rank documents according to the user information needed, so IR can be viewed as ordinal regression problem. Two parameter learning algorithms for ORM are presented. One is a perceptron-based algorithm. The other is the ranking Support Vector Machine (SVM). The effectiveness of the proposed approach has been evaluated on the task of ad hoc retrieval using three English Text REtrieval Conference (TREC) sets and two Chinese TREC sets. Results show that ORM significantly outperforms the state-of-the-art language model approaches and OKAPI system in all test sets; and it is more appropriate to view IR as ordinal regression other than binary classification. 相似文献
157.
将计算得到的大量数据,通过短小的接口Lisp程序的转化,在CAD制图环境中绘制较复杂的曲线图,以解决实际生产需求. 相似文献
158.
Xin-Ge Fu Ke Shi Jian-Liang Xue Chuan Chen Yu Bai Yan-Lu Qiao Yi-Xuan Liu Xiang-Ming Hu Yu Gao Hao Yu 《石油科学(英文版)》2021,(5):1543-1550
In order to effectively control petroleum hydrocarbon pollution by immobilisation technology,it is necessary to understanding the degradation pathways of petrol... 相似文献
159.
Tuili(推理)语言的编译方法与实现技术 总被引:1,自引:0,他引:1
通用交互式逻辑推理语言Tuili是能够进行不同方向并能选择不同搜索策略进行推理的人工智能语言,特别适合快速建造专家系统或基于知识的系统。它的实现将使这一新颖的推理语言的应用成为可能。本文给出作者已经实现的一个Tuili系统中用到的编译方法和主要的实现技术。 相似文献
160.