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排序方式: 共有361条查询结果,搜索用时 15 毫秒
71.
Alessandro Pezzella Luigia Capelli Aniello Costantini Giuseppina Luciani Fabiana Tescione Brigida Silvestri Giuseppe Vitiello Francesco Branda 《Materials science & engineering. C, Materials for biological applications》2013,33(1):347-355
A large number of recent literature data focus on modification/modulation of surface chemistry of inorganic materials in order to improve their functional properties. Melanins, a wide class of natural pigments, are recently emerging as a powerful organic component for developing bioinspired active material for a large number of applications from organoelectronics to bioactive compounds.Here we report the use of the approach referred as “chimie douce”, involving in situ formation of the hybrids through reactions of precursors under mild conditions, to prepare novel hybrid functional architectures based on eumelanin like 5,6 dihydroxyindole-2-carboxylic acid (DHICA) polymer and TiO2. Two synthesis procedures were carried out to get DHICA-melanin coated TiO2 nanoparticles as well as mixed DHICA/TiO2 hybrid nanostructures. Such systems were characterized through EPR, FT-IR and fluorescence spectroscopy, thermogravimetric analysis (TGA), X-ray diffraction (XRD), and TEM microscopy in order to assess the effect of synthesis path as well as of DHICA content on structural, morphological and optical properties of TiO2 nanostructures. In particular, EPR, FT-IR spectra and TGA analysis confirmed the presence of DHICA-melanin in these samples. TEM measurements indicated the formation of the nanoparticles having relatively narrow size distribution with average particle size of about 10 nm. DHICA-melanin does act as a morphological agent affecting morphology of hybrid nanostructures. XRD analysis proved that TiO2 hybrid nanoparticles kept anatase structures for DHICA-melanin contents within the range of investigated compositions, i.e. up to 50% wt/wt. 相似文献
72.
The effect of thiol content on the gelation and mucoadhesion of thiolated poly(aspartic acid)
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Barnabás Áron Szilágyi Benjámin Gyarmati Gabriella Horvát Ádám Laki Mária Budai‐Szűcs Erzsébet Csányi Giuseppina Sandri Maria Cristina Bonferoni András Szilágyi 《Polymer International》2017,66(11):1538-1545
A synthetic poly(amino acid), poly(aspartic acid) modified with thioethyl side groups, was studied as an in situ gelling and mucoadhesive dosage form. The chemical structure and the controllable, large thiol content of the polymer were confirmed using 1H NMR spectroscopy and Ellman's assay. In situ gelation of aqueous polymer solutions was induced by oxidation and monitored using oscillation rheometry. The strength of mucoadhesion towards excised mucosa was characterised by tensile tests in ex vivo experiments. Release kinetics of ophthalmic antibiotic ofloxacin was studied from an in situ crosslinked hydrogel and a liquid formulation to prove the sustained release of the former. © 2017 Society of Chemical Industry 相似文献
73.
Bella Federico Muñoz-García Ana B. Meligrana Giuseppina Lamberti Andrea Destro Matteo Pavone Michele Gerbaldi Claudio 《Nano Research》2017,10(8):2891-2903
Due to their inherent safety,low cost,and structural stability,TiO2 nanostructures represent a suitable choice as anode materials in sodium-ion batteries.In the recent years,various hypotheses have been proposed regarding the actual mechanism of the reversible insertion of sodium ions in the TiO2 structure,and previous reports are often controversial in this respect.Interestingly,when tested as binder-and conducting additive-free electrodes in laboratory-scale sodium cells,amorphous and crystalline (anatase) TiO2 nanotubular arrays obtained by simple anodic oxidation exhibit peculiar and intrinsically different electrochemical responses.In particular,after the initial electrochemical activation,anatase TiO2 shows excellent rate capability and very stable long-term cycling performance with larger specific capacities,and thus a clearly superior response compared with the amorphous counterpart.To obtain deeper insight,the present materials are thoroughly characterized by scanning electron microscopy and ex situ X-ray diffraction,and the insertion of sodium ions in the TiO2 bulk phases is systematically modeled by density functional theory calculations.The present results may contribute to the development of more systematic screening approaches to identify suitable active materials for highly efficient sodium-based energy storage systems. 相似文献
74.
Serena Dato Paolina Crocco Patrizia D’Aquila Francesco de Rango Dina Bellizzi Giuseppina Rose Giuseppe Passarino 《International journal of molecular sciences》2013,14(8):16443-16472
Oxidative stress is both the cause and consequence of impaired functional homeostasis characterizing human aging. The worsening efficiency of stress response with age represents a health risk and leads to the onset and accrual of major age-related diseases. In contrast, centenarians seem to have evolved conservative stress response mechanisms, probably derived from a combination of a diet rich in natural antioxidants, an active lifestyle and a favorable genetic background, particularly rich in genetic variants able to counteract the stress overload at the level of both nuclear and mitochondrial DNA. The integration of these factors could allow centenarians to maintain moderate levels of free radicals that exert beneficial signaling and modulator effects on cellular metabolism. Considering the hot debate on the efficacy of antioxidant supplementation in promoting healthy aging, in this review we gathered the existing information regarding genetic variability and lifestyle factors which potentially modulate the stress response at old age. Evidence reported here suggests that the integration of lifestyle factors (moderate physical activity and healthy nutrition) and genetic background could shift the balance in favor of the antioxidant cellular machinery by activating appropriate defense mechanisms in response to exceeding external and internal stress levels, and thus possibly achieving the prospect of living a longer life. 相似文献
75.
Elisa Sartini Giuseppina P. Parpinello Sergio Galassi 《International Journal of Food Properties》2013,16(5):1081-1089
This research represents a first attempt to chemically characterize wines produced from the autochthonous grape variety, Uva Longanesi, based upon the phenolic compounds responsible for its high astringency as confirmed by preliminary sensory analysis. In addition, a wine produced from Sangiovese, the most popular grape variety in the Emilia-Romagna region, was analyzed for comparative purposes. Results showed that Uva Longanesi wine had a higher pH, alcohol concentration, and total dry extract than the Sangiovese wine. With regards to phenolic constituents, the Uva Longanesi wine had higher color parameters and greater concentrations of total phenolics, including monomeric anthocyanins, small polymeric pigments, and tannins. The phenolic composition of Uva Longanesi wine was found to be responsible for the high reactivity of the wine during fining trials. 相似文献
76.
New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding
Annalia Focà Luca Sanguigno Giuseppina Focà Luigi Strizzi Roberta Iannitti Rosanna Palumbo Mary J. C. Hendrix Antonio Leonardi Menotti Ruvo Annamaria Sandomenico 《International journal of molecular sciences》2015,16(9):21342-21362
Nodal is a potent embryonic morphogen belonging to the TGF-β superfamily. Typically, it also binds to the ALK4/ActRIIB receptor complex in the presence of the co-receptor Cripto-1. Nodal expression is physiologically restricted to embryonic tissues and human embryonic stem cells, is absent in normal cells but re-emerges in several human cancers, including melanoma, breast, and colon cancer. Our aim was to obtain mAbs able to recognize Nodal on a major CBR (Cripto-Binding-Region) site and to block the Cripto-1-mediated signalling. To achieve this, antibodies were raised against hNodal(44–67) and mAbs generated by the hybridoma technology. We have selected one mAb, named 3D1, which strongly associates with full-length rhNodal (KD 1.4 nM) and recognizes the endogenous protein in a panel of human melanoma cell lines by western blot and FACS analyses. 3D1 inhibits the Nodal-Cripto-1 binding and blocks Smad2/3 phosphorylation. Data suggest that inhibition of the Nodal-Cripto-1 axis is a valid therapeutic approach against melanoma and 3D1 is a promising and interesting agent for blocking Nodal-Cripto mediated tumor development. These findings increase the interest for Nodal as both a diagnostic and prognostic marker and as a potential new target for therapeutic intervention. 相似文献
77.
Abstract The large-scale deployment of wide-area monitoring systems could play a strategic role in supporting the evolution of traditional power systems toward smarter and self-healing grids. The correct operation of these synchronized monitoring systems requires a common and accurate timing reference usually provided by a satellite-based global positioning system. Although these satellites signals provide timing accuracy that easily exceeds the needs of the power industry, they are extremely vulnerable to radio frequency interference. Consequently, a comprehensive analysis aimed at identifying their potential vulnerabilities is of paramount importance for correct and safe wide-area monitoring system operation. Armed with such a vision, this article presents and discusses the results of an experimental analysis aimed at characterizing the vulnerability of global positioning system based wide-area monitoring systems to external interferences. The article outlines the potential strategies that could be adopted to protect global positioning system receivers from external cyber-attacks and proposes decentralized defense strategies based on self-organizing sensor networks aimed at assuring correct time synchronization in the presence of external attacks. 相似文献
78.
In the first months when the iPhone deployed, it represented less than 1% of the mobile devices in the U.S. market, yet it accounted for over 50% of the nationally utilized backhaul capacity. Numerous other mobile end-user devices with similar or more ravenous capacity capabilities also entered the market. The 1980s-era mobile network designs that brought, at most, one or two T1s to a mobile base station were over. The era that required dramatically higher backhaul rates delivered to substantially larger numbers of towers and buildings had begun. 相似文献
79.
80.
Daria Brambilla Cesare Mancuso Mariagrazia Rita Scuderi Paolo Bosco Giuseppina Cantarella Laurence Lempereur Giulia Di Benedetto Salvatore Pezzino Renato Bernardini 《Nutrition journal》2008,7(1):29
This review will discuss some issues related to the risk/benefit profile of the use of dietary antioxidants. Thus, recent
progress regarding the potential benefit of dietary antioxidants in the treatment of chronic diseases with a special focus
on immune system and neurodegenerative disorders will be discussed here. It is well established that reactive oxygen species
(ROS) play an important role in the etiology of numerous diseases, such as atherosclerosis, diabetes and cancer. Among the
physiological defense system of the cell, the relevance of antioxidant molecules, such as glutathione and vitamins is quite
well established. Recently, the interest of researchers has, for example, been conveyed on antioxidant enzyme systems, such
as the heme oxygenase/biliverdin reductase system, which appears modulated by dietary antioxidant molecules, including polyphenols
and beta-carotene. These systems possibly counteract oxidative damage very efficiently and finally modulate the activity of
oxidative phenomena occurring, for instance, during pathophysiological processes. Although evidence shows that antioxidant
treatment results in cytoprotection, the potential clinical benefit deriving from both nutritional and supplemental antioxidants
is still under wide debate. In this line, the inappropriate assumption of some lipophylic vitamins has been associated with
increased incidence of cancer rather than with beneficial effects. 相似文献