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81.
Mattia Emanuela Ligotti Anna Aiello Giulia Accardi Anna Calabr Marcello Ciaccio Claudia Colomba Danilo Di Bona Bruna Lo Sasso Fanny Pojero Antonino Tuttolomondo Calogero Caruso Giuseppina Candore Giovanni Duro 《International journal of molecular sciences》2022,23(24)
Natural killer (NK) cells play a role in defence against viral infections by killing infected cells or by producing cytokines and interacting with adaptive immune cells. Killer immunoglobulin-like receptors (KIRs) regulate the activation of NK cells through their interaction with human leucocyte antigens (HLA). Ninety-six Sicilian patients positive to Human Immunodeficiency Virus-1 (HIV) and ninety-two Sicilian patients positive to SARS-CoV-2 were genotyped for KIRs and their HLA ligands. We also included fifty-six Sicilian patients with chronic hepatitis B (CHB) already recruited in our previous study. The aim of this study was to compare the distribution of KIR–HLA genes/groups of these three different infected populations with healthy Sicilian donors from the literature. We showed that the inhibitory KIR3DL1 gene and the KIR3DL1/HLA-B Bw4 pairing were more prevalent in individual CHB. At the same time, the frequency of HLA-C2 was increased in CHB compared to other groups. In contrast, the HLA-C1 ligand seems to have no contribution to CHB progression whereas it was significantly higher in COVID-19 and HIV-positive than healthy controls. These results suggest that specific KIR–HLA combinations can predict the outcome/susceptibility of these viral infections and allows to plan successful customized therapeutic strategies. 相似文献
82.
A Sandri L Besenzon A Acquaviva C Marino L Cordero di Montezemolo E Madon 《Canadian Metallurgical Quarterly》1998,15(6):557-561
OBJECTIVE: To evaluate whether the addition of bismuth subnitrate to a dual oral therapy regimen with omeprazole plus amoxycillin could improve Helicobacter pylori eradication. METHODS: Fifty consecutive Helicobacter pylori-positive patients were randomly enrolled to receive either (A) bismuth subnitrate (300 mg q.d.s.), omeprazole (20 mg b.d.) and amoxycillin (500 mg q.d.s.), or (B) omeprazole (20 mg b.d.) and amoxycillin (500 mg q.d.s.). Both groups (n=25 each) received the medication for 14 days. H. pylori status was reassessed 30 days after completion of the therapy in order to evaluate eradication rates. RESULTS: Six patients were lost to follow-up and therefore excluded from the study (three patients from each group). One patient from Group B withdrew from the study because of side-effects. The addition of bismuth subnitrate to omeprazole and amoxycillin significantly improved its efficacy in eradicating H. pylori, with 72% (18/25) eradication in Group A and 52% (13/25) in Group B (P=0.027). The addition of bismuth subnitrate to dual oral therapy was also capable of improving the healing of peptic ulcers when compared with dual oral therapy alone (100%, 8/8 vs. 58%, 4/7; P=0.021). CONCLUSION: Our results demonstrate that the addition of bismuth subnitrate to dual oral therapy enhances H. pylori eradication, and improves healing of peptic ulcers. 相似文献
83.
Giuseppina Adiletta Gerardo Iannone Paola Russo Giovanni Patimo Salvatore De Pasquale Marisa Di Matteo 《International Journal of Food Science & Technology》2014,49(12):2602-2609
The paper investigated the effect of hot‐air drying (50, 60 °C) on the physical properties of cylindrical eggplant samples. Drying kinetics, water profiles along longitudinal and transversal sample sections through nuclear magnetic resonance imaging (MRI) and volumetric shrinkage were determined. During the drying process at 50 °C, the volume of removed water was found lower than the reduction in sample volume, while at 60 °C it was higher. MRI showed that the water migration mainly occurs transversally than longitudinally. The curves of mass water loss obtained by both the standard weighting method and MRI showed conformity. Experimental data of moisture ratio and of shrinkage volume were fitted using empirical models available in the literature. This preliminary study showed that the nondestructive MRI technique offers the possibility to study water distribution in food during drying processes. The quantitative moisture distribution maps allow future development and verification of models for prediction of mass transport phenomena in foods during drying. 相似文献
84.
Guido Soliveri Daniela Meroni Giuseppe Cappelletti Rita Annunziata Valentina Aina Giuseppina Cerrato Silvia Ardizzone 《Journal of Materials Science》2014,49(7):2734-2744
Siloxane/oxide hybrids have attracted growing attention thanks to their ability to modulate the surface energy, wettability, or self-lubricity of a material. Here, we compare two functionalisation procedures (chemical vapour deposition and wet impregnation) on substrate films composed by preformed oxide particles. Three kinds of particles, characterised by different natures (SiO2 and TiO2) and average particle size, were studied to highlight possible effects related to the chemical and morphological state of the substrate surface. Morphological characterisations were carried out using dynamic light scattering and scanning electron microscopy, while the structure of the hydrophobing layer was studied by combining Fourier transform infrared spectroscopy and solid-state nuclear magnetic resonance. The degree of functionalisation and the features of the siloxane layer vary significantly among the adopted oxides and functionalisation methods. The wettability features of the different hybrids closely mirror the results of the spectroscopic characterisations, giving rise to either Lotus leaf or patch-wise hydrophobic systems depending on the adopted conditions. 相似文献
85.
86.
We present the design criteria and the basic structure of GYPSY, a software laboratory for visual inspection and recognition in industrial automation tasks.GYPSY analyzes images of objects on the basis of their two-dimensional shape. It is fully portable and easily programmable. The user can write application programs in a Pascal-like language to give the system the ability to take over various tasks.GYPSY has been developed for a multi-microprocessor architecture designed in Italy especially for industrial automation. 相似文献
87.
Elisa Sartini Giuseppina P. Parpinello Sergio Galassi 《International Journal of Food Properties》2013,16(5):1081-1089
This research represents a first attempt to chemically characterize wines produced from the autochthonous grape variety, Uva Longanesi, based upon the phenolic compounds responsible for its high astringency as confirmed by preliminary sensory analysis. In addition, a wine produced from Sangiovese, the most popular grape variety in the Emilia-Romagna region, was analyzed for comparative purposes. Results showed that Uva Longanesi wine had a higher pH, alcohol concentration, and total dry extract than the Sangiovese wine. With regards to phenolic constituents, the Uva Longanesi wine had higher color parameters and greater concentrations of total phenolics, including monomeric anthocyanins, small polymeric pigments, and tannins. The phenolic composition of Uva Longanesi wine was found to be responsible for the high reactivity of the wine during fining trials. 相似文献
88.
Alessandro Pezzella Luigia Capelli Aniello Costantini Giuseppina Luciani Fabiana Tescione Brigida Silvestri Giuseppe Vitiello Francesco Branda 《Materials science & engineering. C, Materials for biological applications》2013,33(1):347-355
A large number of recent literature data focus on modification/modulation of surface chemistry of inorganic materials in order to improve their functional properties. Melanins, a wide class of natural pigments, are recently emerging as a powerful organic component for developing bioinspired active material for a large number of applications from organoelectronics to bioactive compounds.Here we report the use of the approach referred as “chimie douce”, involving in situ formation of the hybrids through reactions of precursors under mild conditions, to prepare novel hybrid functional architectures based on eumelanin like 5,6 dihydroxyindole-2-carboxylic acid (DHICA) polymer and TiO2. Two synthesis procedures were carried out to get DHICA-melanin coated TiO2 nanoparticles as well as mixed DHICA/TiO2 hybrid nanostructures. Such systems were characterized through EPR, FT-IR and fluorescence spectroscopy, thermogravimetric analysis (TGA), X-ray diffraction (XRD), and TEM microscopy in order to assess the effect of synthesis path as well as of DHICA content on structural, morphological and optical properties of TiO2 nanostructures. In particular, EPR, FT-IR spectra and TGA analysis confirmed the presence of DHICA-melanin in these samples. TEM measurements indicated the formation of the nanoparticles having relatively narrow size distribution with average particle size of about 10 nm. DHICA-melanin does act as a morphological agent affecting morphology of hybrid nanostructures. XRD analysis proved that TiO2 hybrid nanoparticles kept anatase structures for DHICA-melanin contents within the range of investigated compositions, i.e. up to 50% wt/wt. 相似文献
89.
Valentina Aina Loredana Bergandi Gigliola Lusvardi Gianluca Malavasi Flora E. Imrie Iain R. Gibson Giuseppina Cerrato Dario Ghigo 《Materials science & engineering. C, Materials for biological applications》2013,33(3):1132-1142
A series of Sr-substituted hydroxyapatites (HA), of general formula Ca(10 ? x)Srx(PO4)6(OH)2, where x = 2 and 4, were synthesized by solid state methods and characterized extensively. The reactivity of these materials in cell culture medium was evaluated, and the behavior towards MG-63 osteoblast cells (in terms of cytotoxicity and proliferation assays) was studied. Future in vivo studies will give further insights into the behavior of the materials.A paper by Lagergren et al. (1975), concerning Sr-substituted HA prepared by a solid state method, reports that the presence of Sr in the apatite composition strongly influences the apatite diffraction patterns. Zeglinsky et al. (2012) investigated Sr-substituted HA by ab initio methods and Rietveld analyses and reported changes in the HA unit cell volume and shape due to the Sr addition.To further clarify the role played by the addition of Sr on the physico-chemical properties of these materials we prepared Sr-substituted HA compositions by a solid state method, using different reagents, thermal treatments and a multi-technique approach. Our results indicated that the introduction of Sr at the levels considered here does influence the structure of HA. There is also evidence of a decrease in the crystallinity degree of the materials upon Sr addition. The introduction of increasing amounts of Sr into the HA composition causes a decrease in the specific surface area and an enrichment of Sr-apatite phase at the surface of the samples. Bioactivity tests show that the presence of Sr causes changes in particle size and/or morphology during soaking in MEM solution; on the contrary the morphology of pure HA does not change after 14 days of reaction. The presence of Sr, as Sr-substituted HA and SrCl2, in cultures of human MG-63 osteoblasts did not produce any cytotoxic effect. In fact, Sr-substituted HA increased the proliferation of osteoblast cells and enhanced cell differentiation: Sr in HA has a positive effect on MG-63 cells. In contrast, Sr ions alone, at the concentrations released by Sr-HA (1.21–3.24 ppm), influenced neither cell proliferation nor differentiation. Thus the positive effects of Sr in Sr-HA materials are probably due to the co-action of other ions such as Ca and P. 相似文献
90.
Industrial interest about Incremental Sheet Forming (ISF) process is growing in the last years. Up to a few years ago, two main investigation ways were proposed, the former aimed at analysing the process mechanics, the latter at reproducing some ??case study?? geometries. In industrial applications, if the long cycle-time can be neglected in small batches manufacturing, geometrical accuracy represents a relevant drawback, especially when the product has to be coupled to one another. For this reason, in the opinion of the authors, the low accuracy is the most relevant defect of ISF processes today. Among the techniques already set-up to reduce inaccuracy, the use of different material supports or the use of ??arbitrarily modified?? tool trajectories are probably the most known. In this paper a simple approach is proposed, based on the process self capability to correct inaccuracy when different steps of Incremental Sheet Forming are carried out on both the part surfaces. In particular, it is demonstrated that a relevant increasing in accuracy is obtainable at the second repeated step, while new ones do not reduce the inaccuracy sensitively. The above approach builds a new scenario since it allows to keep the basic equipment (without any support) and does not require any further knowledge concerning the material behaviour after the punch action. These aspects are deeply discussed in the next chapters. 相似文献