A series of nanoparticles with phase-separated structures by 1,1-diphenylethene controlled one-step soap-free emulsion copolymerization and their application in drug release

A facile one-step approach to synthesize various phase-separated porous, raspberry-like, flower-like, core–shell and anomalous nanoparticles and nanocapsules via 1,1-diphenylethene (DPE) controlled soap-free emulsion copolymerization of styrene (S) with glycidyl methacrylate (GMA), or acrylic acid (AA) is reported. By regulating the mass ratio of S/GMA, transparent polymer solution, porous and anomalous P(S-GMA) particles could be produced. The P(S-GMA) particles turn from flower-like to raspberry-like and then to anomalous structures with smooth surface as the increase of divinylbenzene (DVB) crosslinker. Transparent polymer solution, nanocapsules and core–shell P(S-AA) particles could be obtained by altering the mole ratio of S/AA; anomalous and raspberry-like P(S-AA) particles are produced by adding DVB. The unpolymerized S resulted from the low monomer conversion in the presence of DPE aggregates to form nano-sized droplets, and migrates towards the external surfaces of the GMA-enriched P(S-GMA) particles and the internal bulk of the AA-enriched P(S-AA) particles. The nano-sized droplets function as in situ porogen, porous P(S-GMA) particles and P(S-AA) nanocapsules are produced when the porogen is removed. This novel, facile, one-step method with excellent controllability and reproducibility will inspire new strategies for creating hierarchical phase-separated polymeric particles with various structures by simply altering the species and ratio of comonomers. The drug loading and release experiments on the porous particles and nanocapsules demonstrate that the release of doxorubicin hydrochloride is very slow in weakly basic environment and quick in weakly acidic environment, which enables the porous particles and nanocapsules with promising potential in drug delivery applications.

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高效能空气净化器评价技术要求国家标准研究

本文论述了编制高效能空气净化器产品评价技术要求国家标准的意义和作用,介绍了标准研制的总体思路和原则,高效能空气净化器的定性和定量评价指标要求,测试、计算和评价方法等,通过国标的研制与实施,将引领并促进高效能空气净化器产品的生产与应用.     

Large capacitance and fast polarization response of thin electrolyte dielectrics by spin coating for two-dimensional MoS2 devices

Nano Research - A spin-coating method was applied to obtain thinner and smoother PEO/LiClO4 polymer electrolyte films (EFs) with a lower level of crystallization than those obtained using a...     

Peptidyl Virus-Like Nanovesicles as Reconfigurable “Trojan Horse” for Targeted siRNA Delivery and Synergistic Inhibition of Cancer Cells

The self-assembly of peptidyl virus-like nanovesicles (pVLNs) composed of highly ordered peptide bilayer membranes that encapsulate the small interfering RNA (siRNA) is reported. The targeting and enzyme-responsive sequences on the bilayer's surface allow the pVLNs to enter cancer cells with high efficiency and control the release of genetic drugs in response to the subcellular environment. By transforming its structure in response to the highly expressed enzyme matrix metalloproteinase 7 (MMP-7) in cancer cells, it helps the siRNA escape from the lysosomes, resulting in a final silencing efficiency of 92%. Moreover, the pVLNs can serve as reconfigurable “Trojan horse” by transforming into membranes triggered by the MMP-7 and disrupting the cytoplasmic structure, thereby achieving synergistic anticancer effects and 96% cancer cell mortality with little damage to normal cells. The pVLNs benefit from their biocompatibility, targeting, and enzyme responsiveness, making them a promising platform for gene therapy and anticancer therapy.     

车辆四轮转向系统的控制方法

系统地评述了车辆四轮转向系统的原理及其控制方法的发展,在此基础上指出四轮转向系统的研究必须以闭环综合评价为出发点,并与其它主动安全技术相结合才能真正达到实用阶段。     

ADAPTIVE RANKS CLONE AND k‐NEAREST NEIGHBOR LIST–BASED IMMUNE MULTI‐OBJECTIVE OPTIMIZATION

Artificial immune systems (AIS) are computational systems inspired by the principles and processes of the vertebrate immune system. The AIS‐based algorithms typically exploit the immune system's characteristics of learning and adaptability to solve some complicated problems. Although, several AIS‐based algorithms have proposed to solve multi‐objective optimization problems (MOPs), little focus have been placed on the issues that adaptively use the online discovered solutions. Here, we proposed an adaptive selection scheme and an adaptive ranks clone scheme by the online discovered solutions in different ranks. Accordingly, the dynamic information of the online antibody population is efficiently exploited, which is beneficial to the search process. Furthermore, it has been widely approved that one‐off deletion could not obtain excellent diversity in the final population; therefore, a k‐nearest neighbor list (where k is the number of objectives) is established and maintained to eliminate the solutions in the archive population. The k‐nearest neighbors of each antibody are founded and stored in a list memory. Once an antibody with minimal product of k‐nearest neighbors is deleted, the neighborhood relations of the remaining antibodies in the list memory are updated. Finally, the proposed algorithm is tested on 10 well‐known and frequently used multi‐objective problems and two many‐objective problems with 4, 6, and 8 objectives. Compared with five other state‐of‐the‐art multi‐objective algorithms, namely NSGA‐II, SPEA2, IBEA, HYPE, and NNIA, our method achieves comparable results in terms of convergence, diversity metrics, and computational time.     

EDA9033A在分布式风机性能测试系统中的应用

针对以单片机为核心的风机性能测试系统存在稳定性差、抗干扰能力差、精度低等问题,开发了以PLC为核心、采用互感式采集模块EDA9033A采集风机电参数的分布式风机性能测试系统,给出了该风机性能测试系统的结构,详细介绍了EDA9033A的硬件及软件设计。实际应用表明,EDA9033A采集的风机电参数结果稳定、快速、准确。     

初探民间竹制品之设计意匠——以浙江省缙云地区竹制品的研究为例

英国学者李约瑟在深入研究中国科技史后认为,东亚文明乃是"竹子文明,中国人民的血液里流着竹子的文化"。我国不仅竹资源丰富,更是在竹资源的开发与利用上历史最为悠久的国家。我国南方有着大面积的竹产地,竹子及竹制品对当地的社会经济、民俗文化都有很大的影响。如何对"竹"这一传统材料进行创新性的开发和利用,最大限度的实现竹自身的价值,使制竹产业焕发出新的活力,成为当前研究的主要问题。