Endothelium-dependent effect of perindopril and enalaprilat in rat thoracic aorta

AIM: To study the effect of the angiotensin-converting enzyme (ACE) inhibitors perindopril (Per) and enalaprilat (Ena) on the reactivity of the endothelium in normal rats. METHODS: Male rats were treated intragastrically with Per (2 mg.kg-1.d-1) or placebo (n = 18) for 6 wk. Aorta was isolated for experiment. Another set of isolated aortic rings with and without endothelium were incubated with Ena (0.1 mumol.L-1) for 30 min. Responses to acetylcholine, serotonin, phenylephrine, sodium nitroprusside (SN), and nitroglycerin (Nit) were observed. RESULTS: Endothelium-dependent relaxation to acetylcholine was augmented in aortic rings from rats treated with Per in comparison with control. The IC50 value (95% confidence limits) decreased from 3.8 (0.56-26.1) mumol.L-1 (control group) to 0.98 (0.28-3.41) mumol.L-1 (Per-treated group). The maximal relaxation was augmented from 62 +/- 9% to 78 +/- 10% (P < 0.01). However, the responses to the endothelium-independent vasodilators, SN and Nit, were similar. Serotonin- and phenylephrine-induced contractions were decreased, which were influenced by basal release of endothelium-derived relaxing factor (EDRF). EC50 values was 6.1 (2.6-14.4) nmol.L-1 vs 8.3 (3.6-18.8) nmol.L-1 in comparison with control group and Per-treated group. The maximal contraction was decreased from 2.42 +/- 0.29 g (control group) to 1.96 +/- 0.25 g (treated group) (P < 0.01). Similar results were found in incubation with Ena. CONCLUSION: Ena and Per enhanced the basic release of EDRF from vascular endothelium.     

北京谱仪Ⅱ（BESⅡ）顶点探测器数据获取系统

北京谱仪（ＢＥＳⅡ）顶点探测器数据获取系统是北京谱仪数据获取系统的一部分，该子系统电子学采用快总线标准，本文描述了该系统的硬件结构和软件系统，软件包括快总线系统的微码软件和上层控制软件，该系统的死时间为１．５ｎｓ，对ＢＥＳⅡ系统总死时间的贡献小于０．５ｍｓ。     

强化会计内部控制促进高校科学管理

建立和强化完善的会计内部控制体系,对于高校优化资源,促进科学管理有着重要意义.针对当前高校会计内部控制的不足,提出了若干解决对策.     

医患和谐与建筑设计

我们经常会发现，同样一位医护人员在医院工作场所和在其它地方会表现出不同的性格特质，无论是多么和善的人，到了那种医院环境有时就表现得面目可憎。其实，倒不是个人特质有所改变，而是医疗机构流程的流水线和环境造成的，恶劣的医患关系也因此而愈发不可调和。     

信息化经济发展的新动力——写在石龙以宽带速度驶向E-TOWN之际

“我们在一个非常合适的时期,　在一个非常合适的地点,　召开了一个非常合适的会议。”在2003年的“中国城市信息技术应用高层论坛”上,中国市长协会副会长兼秘书长陶斯亮曾过这样一句话。这个“合适的地点”,就是石龙。 广东中心城镇——石龙　　　　美丽的东江蜿蜒而下的北干流与南支流交汇一处,形成一河三埠的风水宝地——石龙。石龙北靠广州,南临深圳,毗邻香港,距广州69公里,深圳78公里,历来都是东江水运的重要港口。　　　　石龙,已有800年的悠久历史,自宋代开始有人定居。由于东江穿境而过,航运极为便利,石龙在明末清…