In vivo quantification of optical contrast agent dynamics in rat tumors by use of diffuse optical spectroscopy with magnetic resonance imaging coregistration

We present a study of the dynamics of optical contrast agents indocyanine green (ICG) and methylene blue (MB) in an adenocarcinoma rat tumor model. Measurements are conducted with a combined frequency-domain and steady-state optical technique that facilitates rapid measurement of tissue absorption in the 650-1000-nm spectral region. Tumors were also imaged by use of contrast-enhanced magnetic resonance imaging (MRI) and coregistered with the location of the optical probe. The absolute concentrations of contrast agent, oxyhemoglobin, deoxyhemoglobin, and water are measured simultaneously each second for approximately 10 min. The differing tissue uptake kinetics of ICG and MB in these late-stage tumors arise from differences in their effective molecular weights. ICG, because of its binding to plasma proteins, behaves as a macromolecular contrast agent with a low vascular permeability. A compartmental model describing ICG dynamics is used to quantify physiologic parameters related to capillary permeability. In contrast, MB behaves as a small-molecular-weight contrast agent that leaks rapidly from the vasculature into the extravascular, extracellular space, and is sensitive to blood flow and the arterial input function.     

Regular Alumina-Supported Nanoparticles of Iridium, Rhodium and Platinum Under Hydrogen Reduction: Structure, Morphology and Activity in the Neopentane Conversion

Comparative studies of supported metal catalysts are facilitated if the catalysts consist of well-faceted metal particles whose structural changes under reaction conditions are known. We describe the use of regular noble metal crystallites (Ir, Rh and Pt), obtained by epitaxial growth on a single crystal (NaCl) substrate and subsequently contacted with the support by reactive high-vacuum deposition of the oxide, to study the inherent catalytic activity of the metals. Most of these metal particles exhibit defined zone axes parallel to the electron beam direction, which allows a characterization by selected area electron diffraction and lattice plane imaging in the electron microscope. The microstructural changes during activation processes (oxidation and reduction at temperatures up to 723 K) have been studied and correlated with corresponding changes in the conversion of neopentane with excess hydrogen. Particular emphasis was placed on the dependence of the reaction rates on hydrogen pressure. The structural changes at the metal–oxide interface upon reduction above ～673 K may be interpreted as a prestage to alloy formation.     

Artificial Neural Networks for Resonant Frequency Calculation of Rectangular Microstrip Antennas with Thin and Thick Substrates

Neural models based on multilayered perceptrons for computing the resonant frequency of rectangular microstrip antennas with thin and thick substrates are presented. Eleven learning algorithms, Levenberg-Marquardt, conjugate gradient of Fletcher-Reeves, conjugate gradient of Powell-Beale, bayesian regularization, scaled conjugate gradient, Broyden-Fletcher-Goldfarb-Shanno, resilient backpropagation, conjugate of Polak-Ribiére, backpropagation with adaptive learning rate, one-step secant, and backpropagation with momentum, are used to train the multilayered perceptrons. The resonant frequency results obtained by using neural models are in very good agreement with the experimental results available in the literature. When the performances of neural models are compared with each other, the best result is obtained from the multilayered perceptrons trained by Levenberg-Marquardt algorithm.     

Orally active endothelin receptor antagonist BMS-182874 suppresses neointimal development in balloon-injured rat carotid arteries

Vascular smooth muscle cell (SMC) proliferation is an important component in the development of restenosis. Because endothelin (ET) has been reported to act as an SMC mitogen, we postulated that the orally active ETA receptor antagonist BMS-182874 would suppress the development of the intimal lesion that develops in rat carotid arteries after balloon injury. Using cultured rat aortic SMC, we noted that ET-1-stimulated increases in [3H]thymidine incorporation were blocked by BMS-182874. To determine the effect of the drug on intimal lesion formation, we treated rats with BMS-182874 (100 mg/kg orally, p.o.) or vehicle once daily for 3 weeks, beginning 1 week before balloon injury. Two weeks after injury, drug-treated rats had a 35% decrease in lesion area and a 34% decrease in the lesion/media ratio as compared with the vehicle-treated rats. In situ hybridization (ISH) analysis of balloon-injured rat carotid arteries showed an increase in ETA receptor mRNA. These data support the concept that ETA receptor activation contributes to intimal lesion formation by promotion of SMC proliferation and suggest a potential use for ETA receptor antagonists in the amelioration of hyperproliferative vascular diseases, including restenosis.     

The effect of Ag,ZnO, and CuO nanoparticles on the properties of the compatibilized polyethylene/thermoplastic starch blend films

In this study, the effects of Ag, ZnO, and CuO nanoparticles (NPs) on the mechanical, thermal, and biodegradability properties of the compatibilized polyethylene (PE)/thermoplastic starch (TPS) blends were investigated. Polyethylene-grafted maleic anhydride (PE-g-MA) was used as the compatibilizer. The compatibilized PE/TPS blends with different NPs were prepared by melt mixing method in a laboratory scale extruder and then pressurized in the press machine. The use of ZnO NP together with the compatibilizer in PE/TPS-based films significantly increased the tensile stress values. The use of different type NPs did not cause any significant change in the thermal stability of PE/TPS-based films. However, the effects of NPs were observed on the TPS degradation steps. The prepared films with different NPs showed an antibacterial activity between 60% and 70%. The highest crystallinity value was obtained in Ag NP containing films, among others. According to scanning electron microscopy analysis, better distribution was observed for ZnO and Ag NPs than CuO NP. In general, it can be said that the addition of NPs to PE/TPS-based blends significantly reduces the partial biodegradability of the resulting films.     

Two-machine flowshop scheduling with flexible operations and controllable processing times

We consider a two-machine flowshop scheduling problem with identical jobs. Each of these jobs has three operations, where the first operation must be performed on the first machine, the second operation must be performed on the second machine, and the third operation (named as flexible operation) can be performed on either machine but cannot be preempted. Highly flexible CNC machines are capable of performing different operations. Furthermore, the processing times on these machines can be changed easily in albeit of higher manufacturing cost by adjusting the machining parameters like the speed and/or feed rate of the machine. The overall problem is to determine the assignment of the flexible operations to the machines and processing times for each operation to minimize the total manufacturing cost and makespan simultaneously. For such a bicriteria problem, there is no unique optimum but a set of nondominated solutions. Using ?-constraint$?\mathrm{-}\mathrm{constraint}$ approach, the problem could be transformed to be minimizing total manufacturing cost for a given upper limit on the makespan. The resulting single criterion problem can be reformulated as a mixed integer nonlinear problem with a set of linear constraints. We use this formulation to optimally solve small instances of the problem while a heuristic procedure is constructed to solve larger instances in a reasonable time.     

Context-based literature digital collection search

We identify two issues with searching literature digital collections within digital libraries: (a) there are no effective paper-scoring and ranking mechanisms. Without a scoring and ranking system, users are often forced to scan a large and diverse set of publications listed as search results and potentially miss the important ones. (b) Topic diffusion is a common problem: publications returned by a keyword-based search query often fall into multiple topic areas, not all of which are of interest to users. This paper proposes a new literature digital collection search paradigm that effectively ranks search outputs, while controlling the diversity of keyword-based search query output topics. Our approach is as follows. First, during pre-querying, publications are assigned into pre-specified ontology-based contexts, and query-independent context scores are attached to papers with respect to the assigned contexts. When a query is posed, relevant contexts are selected, search is performed within the selected contexts, context scores of publications are revised into relevancy scores with respect to the query at hand and the context that they are in, and query outputs are ranked within each relevant context. This way, we (1) minimize query output topic diversity, (2) reduce query output size, (3) decrease user time spent scanning query results, and (4) increase query output ranking accuracy. Using genomics-oriented PubMed publications as the testbed and Gene Ontology terms as contexts, our experiments indicate that the proposed context-based search approach produces search results with up to 50% higher precision, and reduces the query output size by up to 70%.     

Pure cycles in flexible robotic cells

In this study, an m-machine flexible robotic manufacturing cell consisting of CNC machines is considered. The flexibility of the machines leads to a new class of robot move cycles called the pure cycles. We first model the problem of determining the best pure cycle in an m-machine cell as a special travelling salesman problem in which the distance matrix consists of decision variables as well as parameters. We focus on two specific cycles among the huge class of pure cycles. We prove that, in most of the regions, either one of these two cycles is optimal. For the remaining regions we derive worst case performances of these cycles. We also prove that the set of pure cycles dominates the flowshop-type robot move cycles considered in the literature. As a design problem, we consider the number of machines in a cell as a decision variable. We determine the optimal number of machines that minimizes the cycle time for given cell parameters such as the processing times, robot travel times and the loading/unloading times of the machines.     

Roles of syntax information in directing song development in white-crowned sparrows (zonotrichia leucophrys).

Syntactical cues play an important role in song learning in songbirds. White-crowned sparrows (Zonotrichia leucophrys), whose song typically consists of four to five different phrases, fail to construct normal songs if exposed to all phrase types presented singly (Plamondon, Goller, & Rose, 2008; Soha & Marler 2001b). The specific role of acquired syntax information in guiding ontogenetic trajectories of syntax, however, and the respective contributions of instructive and selective processes to syntax ontogeny remain unknown. We tutored white-crowned sparrows with syntax information ranging from acoustic isolation to full song. Manipulation of tutor syntax influenced developmental trajectories of syntax assembly, suggesting that instructive processes contribute to syntax ontogeny. Early in development, birds tutored with full song or phrase pairs preferentially produced phrase pairings matching tutor syntax. Birds tutored with single phrases showed decreased diversity of pairwise syntactical combinations immediately after tutoring compared with other tutor groups, further illustrating the role of instructive processes. Overproduction of song material was also observed, suggesting that selective forces play a role in syntax development as well. Finally, consistent with the notion that innate influences guide syntax ontogeny, birds from all groups exhibited many similarities in trajectories of syntax assembly. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Styrenation of castor oil and linseed oil by macromer method

In this study a novel macromer technique has been described for the styrenation of triglyceride oils. Macromers were prepared through the interesterification of castor oil with linseed oil followed by esterification with acrylic acid. In this preparation various castor oil/linseed oil ratios were applied to obtain a macromer which gave a copolymer with good film properties after copolymerization with styrene. Macromers were styrenated at 100°C using benzoyl peroxide as an initiator. The styrenation leads to improved film properties with the related interesterification product although castor oil is a non‐drying oil.