Network central: regional positioning for innovative advantage

This paper investigates the characteristics of regions that contribute to their positioning within the emerging innovative networks supported by the European Union’s Framework Program using a spatial-network approach. Although the importance of research collaborations in network formation has been generally recognized, relatively little research has investigated why some regions are able to attain prominent network positions, while others do not. We analyze a spatially detailed data base of EU Framework Program-supported research ventures in Austria to understand how specific geographical nodes come to occupy important positions within key research networks. The paper deploys what is termed here a network positioning function to investigate the question of network centrality and at the same time to illustrate the possibilities of combining network and spatial analysis to examine this or other research questions where similar approaches might be applicable. Findings reveal the factors important for understanding advantageous positions enjoyed by regional districts as measured by alternative centrality concepts. Concepts that distinguish innovation exploitation from exploration were used to interpret network positions, which further clarify positioning in highly localized versus distant member networks.     

Synthesis of Bicyclic N‐Arylmethyl‐Substituted Iminoribitol Derivatives as Selective Nucleoside Hydrolase Inhibitors

A series of bicyclic N ‐arylmethyl‐substituted iminoribitols were synthesised and evaluated in vitro against T. vivax nucleoside hydrolase. The importance of the N–Asp40 interaction was confirmed and depends on an optimal pK_a value, which can be influenced by substituents. The compounds were active inhibitors of nucleoside hydrolase (IAG‐NH) and are inactive against human purine nucleoside phosphorylase.

     

Emerging Role of Phospholipase-Derived Cleavage Products in Regulating Eosinophil Activity: Focus on Lysophospholipids,Polyunsaturated Fatty Acids and Eicosanoids

Eosinophils are important effector cells involved in allergic inflammation. When stimulated, eosinophils release a variety of mediators initiating, propagating, and maintaining local inflammation. Both, the activity and concentration of secreted and cytosolic phospholipases (PLAs) are increased in allergic inflammation, promoting the cleavage of phospholipids and thus the production of reactive lipid mediators. Eosinophils express high levels of secreted phospholipase A2 compared to other leukocytes, indicating their direct involvement in the production of lipid mediators during allergic inflammation. On the other side, eosinophils have also been recognized as crucial mediators with regulatory and homeostatic roles in local immunity and repair. Thus, targeting the complex network of lipid mediators offer a unique opportunity to target the over-activation and ‘pro-inflammatory’ phenotype of eosinophils without compromising the survival and functions of tissue-resident and homeostatic eosinophils. Here we provide a comprehensive overview of the critical role of phospholipase-derived lipid mediators in modulating eosinophil activity in health and disease. We focus on lysophospholipids, polyunsaturated fatty acids, and eicosanoids with exciting new perspectives for future drug development.     

Thermo-mechanical behaviour of Shape Memory Polymers, e.g., Tecoflex® by 1WE method: SEM and IR analysis

Thermomechanical cycles including programming, cooling, unloading and heating to trigger the 1WE were examined for a shape memory polymer (SMP), Tecoflex® (TFX EG-72D). Cycles were performed at 60 °C with 65% strains and the recovery time of 10 min. Strains evolving with time were estimated during the thermomechanical treatments for the total 50 cycles using 65% strains. Recovery ratios for 65% strains were also estimated. It turns out that programming, cooling, unloading and heating to trigger the 1WE causes an increase of irreversible strain and is associated with a corresponding decrease of the intensity of the 1WE in particular during the first thermomechanical cycles. Gold coated scanning electron microscopic study using secondary electron imaging (120 times magnified) shows a very little wavy surface structure evolve during cycling up to 300% strains. IR study accurately features the chemical nature after cycling, processing and programming of TFX EG-72D.     

Challenging the system: The role of community choice aggregation in California’s transition to a renewable energy future

There has been a rapid adoption of Community Choice Aggregation (CCA) programs in California. CCAs allow communities to choose their electricity supply through a locally-controlled public agency, disrupting the electric power sector as part of an energy transition. An analysis of how stakeholders in Sonoma and San Diego counties have pursued the implementation of CCAs is conducted through interviews. The findings demonstrate how macro-level pressures created opportunities for niche policies to be developed and challenge the utility-centered electricity model.     

Vakuumerzeugung durch Produktdampf-betriebene Strahlpumpen in der Kunstfaserindustrie

Vacuum generation by product vapour driven jet pumps in the plastic fibre production For industrial application in the fiber industry product vapour driven jet pumps in combination with liquid ring pumps for generation of vacuum have proved and succeeded. The most important advantages of such vacuum systems are the high operational reliability, small wear and tear, customized design, low environmental impact, reasonable investment costs and simple operation.     

Hall sensor response to an inhomogeneous magnetic field

The response of a Hall-effect sensor to a spatially dependent magnetic field is of importance for many applications such as magnetic microscopy and nondestructive testing. Using the analytical expression of the response of a Greek cross Hall sensor response to an ideal field dot published a few years ago, we have calculated its sensitivity and its full width at half maximum for the field produced by a magnetic dipole and by two coplanar lines. The experimental results are in good agreement with theory. They show that the spatial resolution is roughly equal to the dimension of the central part of the Greek cross and that a flux-meter approximation is not appropriate for modeling such Hall-effect sensors for very close field sources.     

Photoelectrochemical kinetics of Eosin Y-sensitized zinc oxide films investigated by scanning electrochemical microscopy under illumination with different LED

The overall efficiency of the light-induced charge separation in dye-sensitized solar cells depends on the kinetic competition between back electron transfer and dye regeneration processes by a redox electrolyte. In a previous study, the reduction of the intermittently formed photo-oxidized dye molecules by iodide ions in the electrolyte phase was investigated using the feedback mode of a scanning electrochemical microscope (SECM) and a quantitative model had been derived. Here we provide a more thorough experimental verification of this model by variation of the excitation wavelength, light intensities and mediator concentrations. Nanoporous ZnO/Eosin Y films prepared by self-assembly were used as model electrodes and were used with an iodide/triiodide electrolyte. The experimentally found effective rate constants could be related to the rate constant for the reaction of the dissolved donor with photo-oxidized Eosin Y bound to ZnO and the absorption spectrum of the dye and confirmed the assumption made in the derivation of the model. For the regeneration process of Eosin Y, a rate constant of k_ox with different light emitting diodes and light intensities is determined.