Target delivery and controlled release of the chemopreventive drug sulindac by using an advanced layered double hydroxide nanomatrix formulation system

Target delivery and controlled release of the chemopreventive drug sulindac that possesses low water solubility present a great challenge for its pharmaceutical industry. Here, we offered an advanced nanomatrix formulation system of sulindac based on layered double hydroxide materials. The X-ray analysis and infrared spectroscopy confirmed the incorporation of sulindac into the gallery of the layered double hydroxides. The incorporation ratios of sulindac were recorded to be 45, 31 and 20 for coprecipitation, anion-exchange and reconstruction techniques, respectively. The scanning electron microscopy showed a nanomatrix-structure of ~50 nm. The release studies of sulindac-nanomatrix showed a 96% controlled release at the small intestine solution during 3 h(s), indicating an enhancement in the dissolution profile of sulindac after the matrix formation. The layered structure of the matrix supplied sulindac with a well-ordered structure and a relatively hydrophobic microenvironment that controlled the guest hydrolysis and reactivity during the release process. The laminar structure of layered double hydroxides offered a safe preservation for sulindac against photodecarboxylation, and enhanced the drug thermal stability from 190 to 230° C. The ionic electrostatic interaction of sulindac through its acidic group with layered double hydroxides demolished the gastrointestinal ulceration.     

Finding the Kool Mixx: how Brown & Williamson used music marketing to sell cigarettes

Objective

To describe the history of Kool''s music‐themed promotions and analyse the role that music played in the promotion of the brand.

Methods

Analysis of previously secret tobacco industry documents, legal documents, and promotional materials.

Results

Brown & Williamson started Kool sponsorship of musical events in 1975 with Kool Jazz concerts. Music was considered to be an effective marketing tool because: (1) music helped consumers make emotional connections with the brand; (2) music concerts were effective for targeted marketing; (3) music tied together an integrated marketing campaign; and (4) music had potential to appeal widely to a young audience. Brown & Williamson''s first music campaigns successfully targeted young African‐American male audiences. Subsequent campaigns were less effective, exploring different types of music to achieve a broader young adult appeal.

Conclusions

This case study suggests Brown & Williamson used music most successfully for targeted marketing, but they failed to develop a wider audience using music because their attempts lacked consistency with the Kool brand''s established identity. The 2004 “Kool Mixx” campaign both returned to Brown & Williamson''s historic practice targeting young African‐American males, and also exploited a musical genre with much more potential to bring Kool more universal appeal, as hip‐hop music is increasingly popular among diverse audiences. Tobacco control efforts led by African‐American community activists to oppose these marketing strategies should continue; expanding these coalitions to include the hip‐hop community may further increase their effectiveness.     

Clear P-wave arrival of weak events and automatic onset determination using wavelet filter banks

P-wave arrivals of many weak events cannot be precisely determined manually. Difference in power levels between noise and P-wave in wavelet detail of weak events enables us to determine P-wave arrival manually. Because of this power difference, automatic onset detection and picking algorithm is introduced using the same wavelet detail. Parameter settings are not needed as algorithm will work on data generated by either short or very broad band seismometers. Application of the proposed algorithm on data of three stations of Egyptian National Seismic Network (ENSN) in Cairo region shows a maximum standard deviation of 0.14 seconds of the corresponding manual picks.     

Efficient Mercury Capture Using Functionalized Porous Organic Polymer

The primary challenge in materials design and synthesis is achieving the balance between performance and economy for real‐world application. This issue is addressed by creating a thiol functionalized porous organic polymer (POP) using simple free radical polymerization techniques to prepare a cost‐effective material with a high density of chelating sites designed for mercury capture and therefore environmental remediation. The resulting POP is able to remove aqueous and airborne mercury with uptake capacities of 1216 and 630 mg g^?1, respectively. The material demonstrates rapid kinetics, capable of dropping the mercury concentration from 5 ppm to 1 ppb, lower than the US Environmental Protection Agency's drinking water limit (2 ppb), within 10 min. Furthermore, the material has the added benefits of recyclability, stability in a broad pH range, and selectivity for toxic metals. These results are attributed to the material's physical properties, which include hierarchical porosity, a high density of chelating sites, and the material's robustness, which improve the thiol availability to bind with mercury as determined by X‐ray photoelectron spectroscopy and X‐ray absorption fine structure studies. The work provides promising results for POPs as an economical material for multiple environmental remediation applications.     

Displacement amplification of piezoelectric microactuators with a micromachined leverage unit

One of the so-called Aero-MEMS applications is the drag reduction on airfoils by using an array of dedicated microactuators. When applying active wave cancellation principles in thin transitional boundary layers, these actuators need to exhibit relatively large stroke at relatively high operational frequencies. For this purpose, a novel micromachined mechanical amplification unit for increasing the stroke of piezoelectric microactuators up to high frequencies is presented in this paper. The mechanical lever is provided by a silicon membrane, sliced in a cake-like fashion. The fabrication and assembly process as well as results of dynamic simulations and experimental measurements are reported. For frequencies from quasi-static up to 15 kHz and for varying spacer positions, an amplification ratio of 5–13 is obtained when comparing displacements at the piezoelement and at the lever tip. Results from finite element simulations were found to be in good agreement with experiments. Finally, the application of these microactuators on airfoils for manipulating the transition point between laminar and turbulent flow conditions is discussed.     

Numerical simulation of steady compressible flows using a zonal formulation. Part I: inviscid flows

Simulation of inviscid flows are usually based on the Euler equations, namely, conservation laws of mass, momentum, and energy written in terms of conservative variables. We present an alternative formulation where the velocity components are calculated from a generalized form of the Cauchy–Riemann equations with a non-homogeneous term representing vorticity. The vorticity is obtained in terms of the gradients of entropy and total enthalpy via Crocco's relation (an expression of the normal momentum equation). The entropy and the total enthalpy are calculated from the tangential momentum and energy equations. For external aerodynamics, most of the field is isentropic and irrotational, and the formulation reduces to potential flow. Hence, two zones are easily identifiable. An inner zone where vorticity could be important, and an outer zone where vorticity is negligible. Preliminary results for two and three dimensional transonic flows over airfoils and wings are presented and compared with standard Euler calculations.     

Relationship between resazurin reduction test, reactive oxygen species generation, and gamma-glutamyltransferase

The production of reactive oxygen species (ROS) from spermatozoa has been measured by chemiluminescence in the two fractions of a Percoll gradient column (47 and 90%). Chemiluminescent signals were recorded in each fraction after addition of luminol and horse-radish peroxidase (basal state), and after stimulation with formyl-methionyl-leucyl-phenyl-alanine (FMLP) and phorbol ester (PMA). We found an inverse correlation between the reducing capacity of the semen as estimated by the resazurin test, and the production of ROS by the spermatozoa, especially after stimulation with PMA (r = 0.51, P < 0.001). gamma-glutamyltransferase activity of seminal plasma was inversely correlated with ROS (r = -0.47, P < 0.01) and the resazurin test result (r = -0.43, P < 0.001) suggesting a possible role of prostatic secretions in the protection of spermatozoa against oxygen radicals. The resazurin test has a positive predictive value of 92.5% at a criterion value of colour scale 4 to discriminate between normal and excessive ROS production by spermatozoa, with sensitivity 79% and specificity 74%. In addition, at criterion value of colour scale 3, the resazurin test could distinguish between samples with normal or low activity of gamma-glutamyltransferase, with sensitivity 57% and specificity 93%. It is concluded that the result of the resazurin test can be influenced by the oxidative stress of spermatozoa and by prostatic function.     

Molecular dynamics modeling of cavity strengthening in irradiated iron

One of the most important problems in the field of nuclear industry is the relationship between irradiation-induced damage and the resulting induced mechanical response of the target metal and in particular ferritic base steels. In this work molecular dynamics simulation is used to simulate the nanoscale interaction between a moving dislocation and a defect, such as a cavity, as void or He bubble. The stress–strain curves are obtained under imposed strain rate condition using the atomic potentials based on the Fe potential of Ackland et al. 1997 for a void and He bubble as a function of He content and temperature. It appears that a 2 nm void is a stronger obstacle than a He bubble at low He contents, whereas at high He contents, the He bubble becomes a stronger obstacle. With increasing temperature the escape stress decreases and at the same time there is increasing degeneracy in the type of interaction.