Randomised trial comparing hysterectomy with endometrial ablation for dysfunctional uterine bleeding: psychiatric and psychosocial aspects

OBJECTIVE: To compare in psychiatric and psychosocial terms the outcome of hysterectomy and endometrial ablation for the treatment of dysfunctional uterine bleeding. DESIGN: Prospective randomised controlled trial. SETTING--Obstetrics and gynaecology department of a large teaching hospital. SUBJECTS: 204 women with dysfunctional bleeding for whom hysterectomy would have been the preferred treatment were recruited over 24 months and randomly allocated to hysterectomy (99 women) or to hysteroscopic surgery (transcervical resection (52 women) or laser ablation (53 women). MAIN OUTCOME MEASURES: Mental state, martial relationship, psychosocial and sexual adjustment in assessments conducted before the operation and one month, six months, and 12 months later. RESULTS: Both treatments significantly reduced the anxiety and depression present before the operation, and there were no differences in mental health between the groups at 12 months. Hysterectomy did not lead to postoperative psychiatric illness. Sexual interest after the operation did not vary with treatment. Overall, 46 out of 185 (25%) women reported a loss sexual interest and 50 out of 185 (27%) reported increased sexual interest. Marital relationships were unaffected by surgery. Personality and duration of dysfunctional uterine bleeding played no significant part in determining outcome. CONCLUSIONS: Hysteroscopic surgery and hysterectomy have a similar effect on psychiatric and psychosocial outcomes. There is no evidence that hysterectomy leads to postoperative psychiatric illness.     

Densification kinetics of coatings being sinter-bonded in a model of viscous flow of a porous solid

Conclusions A theory of sinter-bonding of a powder layer in a model of a linear viscous porous medium is proposed in which the structural transformation of the layer during sinter-bonding is allowed for by introducing two kinetic parameters characterizing sinter-bonding in its initial and final stages; it is shown that there is good agreement between theoretical and experimental data for the isothermal sinter-bonding of PG-SR4 powder in the temperature range 1023–1173°K and the pressure range 10–50 MPa. A study was made of the effect of temperature on the kinetic parameters and of the kinetics of densification of PG-SR4 powder during heating at a constant rate in the range 1100–1250°K; satisfactory agreement is noted between theory and experiment, and the conclusion is arrived at that there exists a lower temperature limit of active sintering.Translated from Poroshkovaya Metallurgiya, No. 8(284), pp. 25–29, August, 1986.     

A new method to implement comminution functions into DEM simulation of a size reduction system due to particle-wall collisions

The ability to design a size reduction system prior to full scale experiments and to optimize existing systems has long been a goal of designers. Such a design and optimization could be achieved by correctly simulating any system under any operating condition. In this paper we present a new and innovative procedure to implement empirical comminution functions into DEM–CFD simulations. The paper is focused on the implementation procedures and not the DEM/CFD simulations, which deserve full attention. Therefore, this paper is not aimed to study any specific mill. The comminution functions include: initial strength distribution, selection function, breakage function and fatigue function. First, the traditional comminution functions (strength distribution, selection and breakage functions) and the recently investigated fatigue function are briefly described and modified. Then a procedure for implementing the functions into a DEM–CFD model or any other source to provide impact velocities and number of impacts, is described in detail. The implementation involves converting the probability comminution functions into individual particle properties by a random method and then converting the velocity dependent comminution functions into strength dependent ones. In this way, and mainly owing to the use of the fatigue function (which defines the weakening of those particles that are not breaking), a real size reduction system, in which each particle is subjected to multiple impacts at various velocities can be simulated. Three case studies for multiple impact conditions at the same average velocity (several impacts at the same velocity, various velocities at each impact and randomly selected velocities) are presented and analyzed in order to confirm qualitatively the procedure, although the comminution functions need to be further quantitatively modified. It should be emphasized that although the new procedure presents a step towards the final goal, some limitations do exist and some questions remain open.     

Numerical Study of Particle Motion in Jet Milling

Jet mills are common devices used in industry for fine milling of dry particulate materials. The size reduction is caused by repeated events of impacts between particles. Although many parameters affect the performance of a jet mill, only a few of them were investigated. Particles' motions in a jet mill have great influence on the comminution process and energy consumption. Therefore, as a first step for a full simulation of the jet-mill process, it was decided to investigate the particle motion inside the jet mill by neglecting particle-particle interaction and particle breakage. In this way, the numerical simulations provide a better understanding of the classification process. In the present study, three-dimensional numerical simulations of particle motion in an industrial full-scale jet mill were conducted. The predictions of the numerical simulations were compared with experimental data and used to analyze the flow field characteristics.     

Dynamic stiffness analysis of laminated beams using a first order shear deformation theory

In this paper the exact vibration frequencies of generally laminated beams are found using a new method, including the effect of rotary inertia and shear deformations. The effect of shear in laminated beams is more significant than in homogenous beams, due to the fact that the ratio of extensional stiffness to the transverse shear stiffness is high. The exact dynamic stiffness matrix is derived, and then any set of boundary conditions including elastic connections, and assembly of members, can be solved as in the classical direct stiffness method for framed structures. The natural frequencies of vibration of a structure are those values of frequency that cause the dynamic stiffness matrix to become singular, and one can find as many frequencies as needed from the same matrix. In the paper several examples are given, and compared with results from the literature.     

An analytical stiffness derivative extended finite element technique for extraction of crack tip Strain Energy Release Rates

An analytical approach combined with the extended finite element method (XFEM) is proposed to extract the Strain Energy Release Rates within the classical stiffness derivative technique. The proposed idea hinges on the following two XFEM properties: (i) the crack is mesh independent, i.e. there is no need for mesh perturbations in the vicinity of the crack and (ii) the asymptotic crack tip field is embedded in the mathematical formulation of the stiffness matrix. By employing these properties we show that the derivative of the stiffness matrix with respect to the crack extension can be computed in a closed form and on the fly during the analysis. Thus the virtual crack extension, and the error inherent in the finite difference scheme of the classical stiffness derivative technique is completely avoided. Numerical results on few benchmark problems show that this method is comparable to the J-integral method.     

Thermosiphon-based PCR reactor: experiment and modeling

A self-actuated, flow-cycling polymerase chain reaction (PCR) reactor that takes advantage of buoyancy forces to continuously circulate reagents in a closed loop through various thermal zones has been constructed, tested, and modeled. The heating required for the PCR is advantageously used to induce fluid motion without the need for a pump. Flow velocities on the order of millimeters per second are readily attainable. In our preliminary prototype, we measured a cross-sectionally averaged velocity of 2.5 mm/s and a cycle time of 104 s. The flow velocity is nearly independent of the loop's length, making the device readily scalable. Successful amplifications of 700- and 305-bp fragments of Bacillus cereus genomic DNA have been demonstrated. Since the device does not require any moving parts, it is particularly suitable for miniature systems.     

Fuzzy and probability vectors as elements of a vector space

The problem of defining vector space operations on fuzzy and probability vectors is discussed. It is shown that such a definition is equivalent to choosing a 1-1 and onto mapping from the unit interval into the real axis. Although such a mapping cannot be continuous, it is suggested that under certain approximations a continuous mapping can be chosen. A characterization of some useful mappings with applications to image processing is also given.     

A disposable,integrated loop-mediated isothermal amplification cassette with thermally actuated valves

An inexpensive, disposable, integrated, polymer-based cassette for loop-mediated isothermal amplification (LAMP) of target nucleic acids was designed, fabricated, and tested. The LAMP chamber was equipped with single-use, thermally actuated valves made with a composite consisting of a mixture of PDMS and expandable microspheres. The effect of the composite composition on its expansion was investigated, and the valve’s performance was evaluated. In its closed state, the valve can hold pressures as high as 200 kPa without any significant leakage. Both the LAMP chamber and the valves were actuated with thin film heaters. The utility of the cassette was demonstrated by carrying out LAMP of Escherichia coli DNA target and reverse transcribed loop meditated isothermal amplification (RT-LAMP) of RNA targets. The amplicons were detected in real time with a portable, compact detector. The system was capable of detecting as few as 10 target molecules per sample in well under 1 h. The portable, integrated cassette system described here is particularly suited for applications at the point of care and in resource-poor countries, where funds and trained personnel are in short supply.     

Nearest Common Ancestors: A Survey and a New Algorithm for a Distributed Environment

Several papers describe linear time algorithms to preprocess a tree, in order to answer subsequent nearest common ancestor queries in constant time. Here, we survey these algorithms and related results. Whereas previous algorithms produce a linear space data structure, in this paper we address the problem of distributing the data structure into short labels associated with the nodes. Localized data structures received much attention recently as they play an important role for distributed applications such as routing. We conclude our survey with a new simple algorithm that labels in O(n) time all the nodes of an n-node rooted tree such that from the labels of any two nodes alone one can compute in constant time the label of their nearest common ancestor. The labels assigned by our algorithm are of size O(log n) bits.