Treatment algorithm use to optimize management of symptomatic patients with a history of mania

BACKGROUND: While monotherapy has significant limitations in bipolar disorder, few published data addressing alternatives exist. Treatment algorithms have been proposed, but none have undergone empirical evaluation. This study provides a systematic prospective, open evaluation of the effectiveness and tolerability of a treatment algorithm for patients with histories of mania. METHOD: Twenty-eight symptomatic outpatients from a public mental health facility who were diagnosed as having either bipolar I or schizoaffective illness, bipolar type, entered the study. Minimum blood levels of lithium and divalproex sodium were defined. Medications were pushed to predetermined levels (as tolerated) before proceeding to the next algorithm step. Clinical symptoms were assessed monthly using the Brief Psychiatric Rating Scale (BPRS, 27 item) and Clinical Global Impressions scale. RESULTS: Pretreatment and posttreatment clinical symptoms were compared. Over 50% of patients attained 30% improvement from baseline BPRS after 4 months. Thirty-six percent of patients (N = 10) became mood stable, 46% (N = 13) remained mood unstable, and 18% (N = 5) dropped out before completing the algorithm. Although patients who finished the algorithm were taking more medication, either dosage and/or drugs, somatic complaints did not increase. CONCLUSION: The potential benefit of a defined treatment algorithm was demonstrated for these complex and persistently ill patients. Despite long treatment histories, patients improved with more frequent visits and addition of medication(s). A randomized controlled trial comparing a similar treatment algorithm with treatment-as-usual is warranted.     

Diagnosis and treatment of iatrogenic ureteral injury

Diagnosis and treatment of 17 patients who sustained 20 iatrogenic ureteral injuries were analyzed. Primary operations in which ureteral injury occurred are almost gynecologic procedures and general surgery. Injuries were managed by ureteroureterostomy in four, ureteral stent in one, removal suture ligation and ureteral double J-catheter in one, ureteroneocystostomy in ten, psoas-hitch technique and ureteroneocystostomy in one, nephrectomy in two. All patients with appropriate repair were followed-up periods of three to five years. Renal function of these patients had optimal results. When ureteral injury occurs, B-US, IVU, cystoscopy, retrograde ureterography or infusion of dye may be useful. An appropriate repair should be chosen according to length and position of ureteral injuries. Reoperation was optimal in two to three weeks. Immediate recognition of accidental ureteral injury provides optimal results. Patients with unrecognized injuries had suboptimal results.     

Ohmic contact and transport properties of II–VI Green/Blue laser diodes

The employment of the Zn(Se,Te) pseudo-graded contacting scheme to p-type ZnSe-based alloys contributes directly to the recent demonstration of room temperature continuous-wave operation of II– VI green-blue laser diodes. Contact ohmicity is maintained down to cryogenic temperatures which enabled the investigation of electrical transport properties associated with the p-type nitrogen-doped ZnSe, Zn(S,Se), and (Zn,Mg)(S,Se). The observation of both persistent photoconductivity and a metastable population of holes which are in thermodynamic equilibrium with hydrogenic acceptors having reduced activation energy suggests the presence of a DX-like behavior for holes in p-type (Zn,Mg)(S,Se).     

项目实训中的协同编程方法研究

在高职院校的软件项目实训环节中,大多项目需要团体协作进行编程。针对如果有效提高学生的协同编程效率、团队合作意识以及合作学习能力的问题,提出了基于Dillenbourg原则的协同编程方法。通过实践证明,该方法取得了良好的实训效果。     

Probability-confidence-kernel-based localized multiple kernel learning with lp norm

Localized multiple kernel learning (LMKL) is an attractive strategy for combining multiple heterogeneous features in terms of their discriminative power for each individual sample. However, models excessively fitting to a specific sample would obstacle the extension to unseen data, while a more general form is often insufficient for diverse locality characterization. Hence, both learning sample-specific local models for each training datum and extending the learned models to unseen test data should be equally addressed in designing LMKL algorithm. In this paper, for an integrative solution, we propose a probability confidence kernel (PCK), which measures per-sample similarity with respect to probabilistic-prediction-based class attribute: The class attribute similarity complements the spatial-similarity-based base kernels for more reasonable locality characterization, and the predefined form of involved class probability density function facilitates the extension to the whole input space and ensures its statistical meaning. Incorporating PCK into support-vectormachine-based LMKL framework, we propose a new PCK-LMKL with arbitrary l(p)-norm constraint implied in the definition of PCKs, where both the parameters in PCK and the final classifier can be efficiently optimized in a joint manner. Evaluations of PCK-LMKL on both benchmark machine learning data sets (ten University of California Irvine (UCI) data sets) and challenging computer vision data sets (15-scene data set and Caltech-101 data set) have shown to achieve state-of-the-art performances.     

The calcium-phosphorus and the simultaneous calcium-oxygen and calcium-sulfur equilibria in liquid iron

The equilibrium Ca₃P_2(s) = 3[Ca] + 2[P] was studied at 1600 ° by equilibrating liquid iron, saturated with Ca₃P₂, and contained in a TiN crucible, with Ca vapor. The source of Ca was liquid Ca contained in an Mo crucible, and the vapor pressure of Ca was varied by varying the position of the Mo crucible in the temperature gradient of a vertical tube furnace. A least-squares analysis of the data gave and. The simultaneous equilibria CaO_(s) = [Ca] + [O] and CaS_(s) = [Ca] + [S] were studied at 1600 ° by equilibrating liquid iron, contained in a pressed and sintered CaO-CaS crucible with Ca vapor. The advantage of this technique is that two equilibrium constants,K _cas andK _cao, and two interaction coefficients, and can be determined from one set of experiments. It was determined that, at 1600 °,K _cas = 5.9 × 10⁻⁸ K _cao = 5.5 × 10⁻⁹,, and. Formerly Graduate Students     

低电压氧化锌压敏电阻器的研究

研究了一种制造低电电压氧化锌压敏电阻器的方法。在基本成分的基础上适当加入二氧化钛可降低梯度电压（Ｖ１ｍＡ／ｍｍ），适量掺硼和改进热处理工艺可减小元件的漏电流和提高其稳定性。     

An Analytical Model Including Interface Traps and Temperature Effects in Negative Capacitance Double Gate Field Effect Transistor

Silicon - In this paper, an analytical model for negative capacitance double gate field effect transistor (NC-DG-FET) is proposed. This model includes interface traps and temperature effects, which...     

混合材对碱—碳酸盐反应的影响

利用快速测长法研究了混合材对碱—碳酸盐反应的影响。通过试验证明混合材能减缓碱—碳酸盐反应的速度,但不能有效地抑制碱—碳酸盐反应,并初步探讨了混合材不能有效地抑制碱—碳酸盐反应的机理。