An Apoptotic Body-based Vehicle with Navigation for Photothermal-Immunotherapy by Precise Delivery and Tumor Microenvironment Regulation

Tumor precision therapy and preventing tumor recurrence and metastasis are the main challenges to tumor eradication. Herein, an apoptotic body-based vehicle with imaging navigation is developed for precise tumor delivery and photothermal-immunotherapy by IR820-conjugated apoptotic body loaded with R848 nanoparticles. The apoptotic body serves as ammunition stores as well as vehicle drive engines, while IR820 acts as a fluorescence imaging navigation and photothermal controlling system. The apoptotic body vehicle can deliver the ammunition to tumor and achieve deep penetration by macrophage-hitchhiking. Fluorescence imaging navigation opens a control window for photothermal treatment, followed by photothermal triggering of in situ vaccine formation. Further, CD47 antibody loaded hydrogel strengthens innate and adaptive immunity, simultaneously the polarization of macrophages regulates the immunosuppressive microenvironment to further promote the combined antitumor immunotherapy. With breast tumor (4T1)-bearing mice model, the apoptotic body vehicle performs excellent therapeutic efficacy for primary tumor, distant tumor, tumor metastasis, and recurrence prevention.     

Finite-Sized Atom Reconstruction Enhanced High-Frequency Multi-Domain Magnetic Response

The technological advances in wearable electronics and military stealth have spawned extensive research into electromagnetic wave absorbents. Despite the rapid progress in the geometrical modulation of magnetic absorbents, the engineering strategy of microwave-responsive magnetic domains is underdeveloped and the response dynamics remain unclear. Herein, a surface finite-sized atom reconstruction procedure is proposed to accurately modulate the local magnetic topological domains, dramatically enhancing the magnetic loss capacity. Due to the selectivity of atom reconstruction, vortex and stripe domains are controllably hybridized around the porous surface to broaden the interactive domain region, significantly intensifying energy absorption of the microwave field. Meanwhile, the amorphous/crystalline interfaces around atom reconstruction regions can induce interfacial polarization, enabling the optimization of dielectric loss capacity. Therefore, a satisfactory magnetic–dielectric synergy is realized to demonstrate the strong absorption intensity of −31.2 dB and the broad absorption bandwidth of 5.9 GHz. Furthermore, the surface-based magnetic domain transformation and microwave energy attenuation mechanisms are thoroughly revealed to break the black box of structure–function through electron holography and micromagnetic simulation. These achievements demonstrate a promising solution to improve high-frequency magnetic properties and provide a feasible route to interpret the structure-relevant magnetic loss capacity.     

基于B/S架构的产品质量监督检验综合服务平台的探讨与开发

本文探讨在新的网络环境下,为适应企业、公众、政府等方面的新需求,对原有C/S结构下产品质量监督检验平台进行改进与提升,通过B/S架构的平台完整实现内部流程和业务的信息化管理,同时对外拓宽检验信息状态及时通知、查询及企业质量状况查询等内容,以适应于我国电子政务和现代管理发展的趋势,更好的建设服务型质检技术支撑机构。     

SGDBR型激光器的波长自动控制系统

根据取样光栅分布布拉格反射器(SGDBR)型激光器的波长调谐原理,设计出用于SGDBR型激光器的波长自动控制系统.利用该系统对自行研制的SGDBR型激光器进行了准确、快速的波长扫描,为器件的动态性能研究奠定了测试基础.     

一种改进的进程调度算法在机顶盒上的设计与实现

调度算法对操作系统中的实时性起着关键的作用.就此问题,深入分析了基于最小优裕度算法的内核进程调度算法,为更好地满足Linux系统对嵌入式系统实时可靠性的要求,对现有的LSF调度策略进行分析,指出LSF算法调度算法的不足.为了改进LSF算法的颠簸现象,基于抢占阈值的思想,提出适用于LSF算法的抢占阈值分配方法,动态地给每...     

Amplifying Nanoparticle Targeting Performance to Tumor via Diels–Alder Cycloaddition

Traditional targeting approach utilizing biological ligands has to face the problems of limited receptors and tumor heterogeneity. Herein, a two‐step tumor‐targeting and therapy strategy based on inverse electron‐demand [4+2] Diels–Alder cycloaddition (iEDDA) is described. Owing to the unique acidic tumor microenvironment, an intravenous injection of tetrazine modified pH (low) insertion peptide could efficiently target and incorporate onto various cell surfaces in tumor tissue, such as cancer cells, vascular endothelial cells, and tumor‐associated fibroblasts. The “receptor‐like” tetrazine groups with a large amount and homogeneous intratumoral distribution could then serve as the baits to greatly amplify the tumor‐targeting ability of indocyanine green (ICG)‐loaded and trans‐cyclooctene (TCO)‐conjugated human serum albumin (HSA) nanoparticles (TCO‐HSA‐ICG NPs) via iEDDA after the second intravenous injection. Compared with the passive enhanced permeability and retention (EPR) effect and traditional active targeting approaches, the targeting performance and photothermal therapeutic effect based on the two‐step strategy are significantly enhanced, while no notable toxicity is observed. As acidity is a characteristic of solid tumor, the two‐step strategy can serve as a universal and promising modality for safe and high‐performance nanoparticle‐based antitumor therapy.     

Study of proton irradiation effects on AlGaN/GaN high electron mobility transistors

AlGaN/GaN high electron mobility transistors (HEMTs) were exposed to 3 MeV protons at fluences of 6 × 10¹³, 4 × 10¹⁴ and 1 × 10¹⁵ protons/cm². The drain saturation currents decreased by 20% and the maximum transconductance decreased by 5% at the highest fluence. As the fluence increased, the threshold voltage shifted more positive values. After proton irradiation, the gate leakage current increased. The Schottky barrier height changed from 0.63 eV to 0.46 eV, and the ideality factor from 2.55 to 3.98 at the highest fluence. The degradations of electrical characteristics of AlGaN/GaN HEMTs are caused by displacement damages induced by proton irradiation. The density of vacancies at different proton fluence can be calculated from SRIM. Being an acceptor-like defect, the Ga vacancy acts as a compensation center. While N vacancy acts as a donor. Adding the vacancies model into Slivaco device simulator, simulation results match well with the trends of experimental data. Hall measurement results also indicate the concentration and mobility of 2DEG decrease after proton irradiation. It is concluded that the Ga vacancies introduced maybe the primary reason for the degradation of AlGaN/GaN HEMTs performance.     

CDMA与线性模拟调制通信质量的比较与分析

CDMA在无线移动通信中受到了“垂青”,得到了通信专家与用户的首肯。为此,笔者将古典的线性模拟调制通信方式与现代的CDMA的性能予以量化比较,得出CDMA的优值可达10以上,优于线性模拟调制。因此选择CDMA作为首选通信方式是有理论依据的。     

Bioinspired Supramolecular Slippery Organogels for Controlling Pathogen Spread by Respiratory Droplets

Surface-deposited pathogens are sources for the spread of infectious diseases. Protecting public facilities with a replaceable or recyclable antifouling coating is a promising approach to control pathogen transmission. However, most antifouling coatings are less effective in preventing pathogen-contained respiratory droplets because these tiny droplets are difficult to repel, and the deposited pathogens can remain viable from hours to days. Inspired by mucus, an antimicrobial supramolecular organogel for the control of microdroplet-mediated pathogen spread is developed. The developed organogel coating harvests a couple of unique features including localized molecular control-release, readily damage healing, and persistent fouling-release properties, which are preferential for antifouling coating. Microdroplets deposited on the organogel surfaces will be spontaneously wrapped with a thin liquid layer, and will therefore be disinfected rapidly due to a mechanism of spatially enhanced release of bactericidal molecules. Furthermore, the persistent fouling-release and damage-healing properties will significantly extend the life-span of the coating, making it promising for diverse applications.     

一种基于家宽网络故障与业务的精准关联技术

在运营商故障监控工作中,OLT退服告警对宽带业务影响范围、家宽实际影响用户数一直是家宽业务关联影响的重要环节,明确OLT退服影响是告警监控重要的目标。提出一种基于家宽网络故障与业务的精准关联技术,将家宽用户信息与告警相结合,实现故障与影响客业务的网络指标自动关联,完成对OLT退服对业务的影响、影响用户精准分析和用户投诉的分析关联,减少用户投诉,提升用户满意度,实现经济效益的提升。