Activation of extracellular matrix metalloproteinases in equine laminitis

Samples of connective tissue obtained from the hoof of six laminitic and eight non-laminitic adult horses were analysed zymographically to investigate whether connective tissue matrix metalloproteinases are activated or induced during laminitis. The activity or matrix metalloproteinases was substantially greater in the tissues from the laminitic horses than in the tissues from the non-laminitic horses. A comparison of the collagenolytic activity in the laminitic and control tissues showed that collagenolytic activities corresponding to the 92 kDa (P < 0.001), 72 kDa (P < 0.01) and 66 kDa (P < 0.01) bands were induced in the laminitic tissues.     

Solving applied general equilibrium models represented as a mixture of linearized and levels equations

General equilibrium moels are usually represented as a system of levels equations (e.g., in North America) or a system of linearized equations (e.g., in Australia). Either representation can be used to obtain accurate solutions. General-purpose software is available in both cases-GAMS or MPS/GE is typically used by levels modellers and GEMPACK by linearizers. Some equations (notably accounting identities) are naturally expressed in the levels while others (especially behavioural equations) are naturally expressed in a linearized form. This paper describes the new GEMPACK facility for solving models represented as a mixture of levels and linearized equations and discusses the advantages to modellers of using such a representation.     

Neuroleptic use and behavioral disturbance in nursing homes: a 1-year study

This article discusses a longitudinal study of change in disruptive behaviors among nursing home residents treated with neuroleptics compared with those not treated with neuroleptics. Observations were made of 201 participants on admission to and after 1 year in eight skilled nursing facilities. Nine disruptive behaviors were measured using the Psychogeriatric Dependency Rating Scale with nursing assistants. Neuroleptic use was documented from medication records. Odds ratios are reported for the association of behavior at baseline and use of neuroleptics on nine problem behaviors. For those who received neuroleptics during the year, there was greater change in both developing and resolving disruptive behaviors than for those not receiving neuroleptics. For both groups, restless or pacing behavior and belligerent behavior manifested by refusing instructions changed the most, both in developing and in apparently resolving. Our results show that change in disruptive behaviors occurs among nursing home residents regardless of neuroleptic use, but it occurs more frequently among those who receive neuroleptic medication. Knowledge of which disruptive behaviors are most likely to resolve or develop is important in training nursing home staff to cope with the behaviors as well as in planning interventions that may modify such behaviors.     

Adding sense to the Internet of Things

The Internet of Things (IoT) concept is being widely presented as the next revolution toward massively distributed information, where any real-world object can automatically participate in the Internet and thus be globally discovered and queried. Despite the consensus on the great potential of the concept and the significant progress in a number of enabling technologies, there is a general lack of an integrated vision on how to realize it. This paper examines the technologies that will be fundamental for realizing the IoT and proposes an architecture that integrates them into a single platform. The architecture introduces the use of the Smart Object framework to encapsulate radio-frequency identification (RFID), sensor technologies, embedded object logic, object ad-hoc networking, and Internet-based information infrastructure. We evaluate the architecture against a number of energy-based performance measures, and also show that it outperforms existing industry standards in metrics such as network throughput, delivery ratio, or routing distance. Finally, we demonstrate the feasibility and flexibility of the architecture by detailing an implementation using Wireless Sensor Networks and Web Services, and describe a prototype for the real-time monitoring of goods flowing through a supply chain.     

The interprocedural analysis and automatic parallelization of Scheme programs

Lisp and its descendants are among the most important and widely used of programming languages. At the same time, parallelism in the architecture of computer systems is becoming commonplace. There is a pressing need to extend the technology of automatic parallelization that has become available to Fortran programmers of parallel machines, to the realm of Lisp programs and symbolic computing. In this paper we present a comprehensive approach to the compilation of Scheme programs for shared-memory multiprocessors. Our strategy has two principal components:interprocedural analysis andprogram restructuring. We introduceprocedure strings andstack configurations as a framework in which to reason about interprocedural side-effects and object lifetimes, and develop a system of interprocedural analysis, using abstract interpretation, that is used in the dependence analysis and memory management of Scheme programs. We introduce the transformations ofexit-loop translation andrecursion splitting to treat the control structures of iteration and recursion that arise commonly in Scheme programs. We propose an alternative representation for s-expressions that facilitates the parallel creation and access of lists. We have implemented these ideas in a parallelizing Scheme compiler and run-time system, and we complement the theory of our work with snapshots of programs during the restructuring process, and some preliminary performance results of the execution of object codes produced by the compiler.This work was supported in part by the National Science Foundation under Grant No. NSF MIP-8410110, the U.S. Department of Energy under Grant No. DE-FG02-85ER25001, the Office of Naval Research under Grant No. ONR N00014-88-K-0686, the U.S. Air Force Office of Scientific Research under Grant No. AFOSR-F49620-86-C-0136, and by a donation from the IBM Corportation.     

The Interaction of Glymes with Surfactant Micelles

The critical micelle concentrations (CMC) values and counterion dissociation (α values) have been determined for a number of mixed micellar systems consisting of two typical ionic surfactants and glycol ethers (glymes) as cosurfactants, namely diethylene glycol dimethyl ether, diethylene glycol diethyl ether, triethylene glycol dimethyl ether, and tetraethylene glycol dimethyl ether. Conductance experiments were used to determine the CMC and α values of the mixed micelles as a function of glyme concentration in the aqueous mixed solvent. Favorable interactions between sodium dodecyl sulfate micelles and glyme cosurfactants were deduced from the decreases in the CMC values and the large increase in the α values of these systems as a function of increasing glyme concentration in the mixed solvents. In contrast to the anionic surfactant/glyme systems, in general, there appeared to be little favorable interactions between the surfactant and glymes when micelles of the cationic surfactant dodecyltrimethylammonium bromide were formed in water/glyme solvent systems containing an increasing amount of the glymes. The interaction of glymes with the surfactant micelles was examined closely via ¹³C nuclear magnetic resonance (NMR) chemical shifts for both surfactant and glyme carbons; these chemical shifts changes were interpreted in terms of the distribution and the localization of the glymes in the aggregates. Finally, partition constants, determined from two-dimensional diffusion-oriented spectroscopy (2D-DOSY) experiments, were used to calculate thermodynamic quantities of transfer of the glymes between the bulk phase and the self-assembled aggregates. All these results are interpreted in terms of the key contributions that both the glyme ethoxylated groups and alkyl endgroups make to the hydrophobic interactions.     

Optimal control and energy storage for DC electric train systems using evolutionary algorithms

Railway Engineering Science - Electrified railways are becoming a popular transport medium and these consume a large amount of electrical energy. Environmental concerns demand reduction in energy...     

X-ray photoelectron spectroscopic study of the oxidation and reduction of a cerium(III) oxide/cerium foil substrate

X-ray photoelectron spectroscopy has been used to examine the nature of the oxide overlayers on a passivated cerium metal foil as a function of a variety of oxidation and reduction treatments. Oxidation of a clean uncontaminated cerium(III) oxide surface is facile at room temperature and produces non-stoichiometric ceria (CeO_2–x) at oxygen doses as low as 10 L. At higher doses the overlayer thickens, and after a dose of 160 L the layer depth exceeds the Ce 3d photoelectron attenuation distance of about 20 Å. High pressure treatment of the foil in oxygen (0.5 bar at RT and 473 K) produces CeO₂ in a high degree of crystallographic order such that O 1s photoelectron intensities are increased above that expected from a randomly oriented powder. An attempt to reduce the CeO₂ layer formed by controlled oxidation with CO (633 K, 14 h, 0.6 bar) results in the formation of a carbonated surface layer. Results following attempts to reoxidise this layer are discussed.