Diamondoid Phosphines – Selective Phosphorylation of Nanodiamonds[1]

The diamondoids (nanodiamonds) diamantane and triamantane were selectively converted into diorganophosphinic acid chlorides by reacting them with phosphorus trichloride under Friedel–Crafts‐like conditions. The di‐diamondoid phosphinic acid chlorides were subsequently reduced with trichlorosilane to give the hitherto unknown corresponding di‐diamondoid phosphines. These diamondoid phosphinic acid chlorides and phosphines are of great utility as starting materials in organo‐element and coordination chemistry due to their extraordinary rigidity and steric bulk.     

Detection of colorectal adenoma and cancer based on transthyretin and C3a-desArg serum levels

Colorectal cancer is the second leading cause of cancer death, and it develops from benign colorectal adenomas in over 95% of patients. Early detection of these cancer precursors by screening tests and their removal can potentially eradicate more than 95% of colorectal cancers before they develop. To discover sensitive and specific biomarkers for improvement of pre‐clinical diagnosis of colorectal adenoma and cancer, we analysed in two independent studies (n = 87 and n = 83 patients) serum samples from colorectal cancer (stage III), colorectal adenoma and control patients using SELDI‐TOF‐MS. Extensive statistical analysis was performed to establish homogeneous patient groups based on their clinical data. Two biomarkers that were each able to distinguish control patients from either colorectal adenoma or colorectal cancer patients (p<0.001) were identified as transthyretin (pre‐albumin) and C3a‐desArg by MS/MS and were further validated by antibody‐based assays (radial immunodiffusion, ELISA). A combination of both proteins clearly indicated the presence of colorectal adenoma or carcinoma. Using a cut‐off of <0.225 g/L for transthyretin and >1974 ng/mL for C3a‐desArg, we found a sensitivity and specificity for colorectal adenoma of 96% and 70%, respectively.     

Novel Aerosol-Based Approach toward Mesoporous Silica Nanoparticles

This study introduces a novel gas-phase method for the synthesis of mesoporous silica nanoparticles (MSNs). The method is a two-step templating approach by first forming silicon-coated carbon structures in a hybrid microwave-plasma/hot-wall reactor followed by an annealing step to produce mesoporous silica with distinct nanostructure and porosity. Two different (sacrificial) carbonaceous templates have been prepared (plasma reactor) and coated (hot-wall reactor), 2D few-layer graphene (FLG) flakes and soot-like fractal aggregates. Results show that the wall thickness of the porous silica structures can be adjusted by changing the concentration of the silicon precursor (monosilane). High monosilane concentrations, however, result in solid silica particles after annealing. Using soot-like particle templates permitted to control of the shell thickness of the hollow porous particles, while the FLG template results in ultrathin silica sheets after heat treatment. The pore volume and specific surface area increase up to 263 m² g⁻¹ and 0.6 cm³ g⁻¹, respectively, by the formation of hollow porous particles. An adsorption study on carbamazepine reveals up to ≈86% removal. The gas-phase aerosol-based template method presented here offers scalability and versatility, and it is capable of producing MSNs with a controlled structure and porosity by modifying the carbonaceous templates.     

Effect of hot strip processing during direct charging of thin slabs on the properties of cold strip of LC-steel

Direct charging of thin slabs of low carbon steel (0.05%C) was investigated by using laboratory tests on a thin-slab-casting Simulator linked with the hot deformation Simulator (Wumsi). Starting with a different initial thickness of simulated thin slabs (45 down to 25 mm) the total strain ?∑ was varied. Hot deformation schedules (with and without roughing) with different finishing temperatures T_F lead to some differences in the hot strip microstructure. Nevertheless, after cold rolling and batch annealing, a rather uniform pancake-structure and a pronounced {111}-texture were achieved in the cold strip without any significant relation to the processing routs. The measurement of final mechanical properties proved that a good deep drawability of cold strip can be achieved with direct charging of thin slabs, well comparable to that after a conventional cold charging of thick slabs.     

Polymers containing formamidine groups

Summary Aliphatic polyformamidines have been synthesized by reaction of aliphatic diamines with triethyl orthoformate in presence of catalytic amounts of acetic acid. The reaction has been carried out in DMSO at 180°C. The polymer structure has been confirmed by IR and NMR spectroscopy. For determination of molecular weights ¹H NMR end group signals have been used.     

Endocrine disrupting nonylphenols are ubiquitous in food

4-Nonylphenols (NPs) are common products of biodegradation of a widely used group of nonionic surfactants, the nonylphenol ethoxylates (NPEs). These compounds are known to be persistent, toxic, and estrogen active. There is a worldwide scientific and public discussion on the potential consequences of human long term dietary exposure to such endocrine disrupters. Despite numerous determinations of NPs in environmental samples no systematical reports exist relating to concentrations of NPs in food. We analyzed NPs in 60 different foodstuff commercially available in Germany. The results indicate that NPs are ubiquitous in food. The concentrations of NPs on a fresh weight basis varied between 0.1 and 19.4 microg/kg regardless of the fat content of the foodstuff. Based on data on German food consumption rates and these first analyses of NPs in food, the daily intake for an adult was calculated to be 7.5 microg/day NPs. For infants exclusively fed with breast milk or infant formulas daily intakes of 0.2 microg/day and 1.4 microg/day NPs, respectively, can be estimated.     

Anisotropic plasticity model coupled with strain dependent plastic strain and stress ratios

It is necessary to describe properly anisotropic material behavior for realistic numerical analyses of sheet metal forming processes. The implementation of many yield criteria in finite element analysis is very complicated. Various material tests are also required to determine yield function coefficients. Stress ratios and anisotropy coefficients are not constant during forming processes due to deformation induced anisotropy. This paper introduces a yield function using strain dependent plastic strain ratios and stress ratios. The main advantage is to fully utilize the data of uniaxial tensile tests. The described material behavior shows a significantly improved agreement with experimental data.     

Modeling and querying moving objects in networks

Moving objects databases have become an important research issue in recent years. For modeling and querying moving objects, there exists a comprehensive framework of abstract data types to describe objects moving freely in the 2D plane, providing data types such as moving point or moving region. However, in many applications people or vehicles move along transportation networks. It makes a lot of sense to model the network explicitly and to describe movements relative to the network rather than unconstrained space, because then it is much easier to formulate in queries relationships between moving objects and the network. Moreover, such models can be better supported in indexing and query processing. In this paper, we extend the ADT approach by modeling networks explicitly and providing data types for static and moving network positions and regions. In a highway network, example entities corresponding to these data types are motels, construction areas, cars, and traffic jams. The network model is not too simplistic; it allows one to distinguish simple roads and divided highways and to describe the possible traversals of junctions precisely. The new types and operations are integrated seamlessly into the ADT framework to achieve a relatively simple, consistent and powerful overall model and query language for constrained and unconstrained movement.