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21.
弹复性是系统在失效或被破坏之后能够恢复正常工作的能力.弹复性工程是当今国际上研究的热点.本文提出了基于节点对间的独立路径可靠度和交通网络的弹复度的定量测算方法,提出了反映节点和路段对交通网络影响大小的易碎性的概念和测算方法.论文还就弹复度和易碎度的几个相关性质提出了几个重要定理.针对我国的铁路网络,计算了所有节点城市和路段的弹复度和易碎度,并对弹复度和易碎度高的节点的分布规律进行了探讨,得出了一些有益的结论. 相似文献
22.
Nikolina Plei Mirjana Babi Leko Ivana Gunja
a Thibaud Boutin Vesela Torlak Antonela Matana Ante Punda Ozren Polaek Caroline Hayward Tatijana Zemunik 《International journal of molecular sciences》2022,23(4)
Thyroglobulin (Tg) is an iodoglycoprotein produced by thyroid follicular cells which acts as an essential substrate for thyroid hormone synthesis. To date, only one genome-wide association study (GWAS) of plasma Tg levels has been performed by our research group. Utilizing recent advancements in computation and modeling, we apply a Bayesian approach to the probabilistic inference of the genetic architecture of Tg. We fitted a Bayesian sparse linear mixed model (BSLMM) and a frequentist linear mixed model (LMM) of 7,289,083 variants in 1096 healthy European-ancestry participants of the Croatian Biobank. Meta-analysis with two independent cohorts (total n = 2109) identified 83 genome-wide significant single nucleotide polymorphisms (SNPs) within the ST6GAL1 gene (). BSLMM revealed additional association signals on chromosomes 1, 8, 10, and 14. For ST6GAL1 and the newly uncovered genes, we provide physiological and pathophysiological explanations of how their expression could be associated with variations in plasma Tg levels. We found that the SNP-heritability of Tg is 17% and that 52% of this variation is due to a small number of 16 variants that have a major effect on Tg levels. Our results suggest that the genetic architecture of plasma Tg is not polygenic, but influenced by a few genes with major effects. 相似文献
23.
Phase equilibrium relations in the system Li2 O-GeO2 were determined using standard quenching techniques. In contrast to published literature five congruently melting compounds were found to exist. They are Li2 O·7GeO2 , 3Li2 O O·8GeO2 , Li2 O O·GeO2 , 3Li2 O O·2GeO2 , and 2Li2 O.-GeO2 . The melting points, respectively, are 1033°± 5°C, 953°± 5°C, 1245°± 15°C, 1125°± 15°C, and 1280°± 15°C. Simple binary eutectic relations exist among the compounds. The eutectic temperature between 1:7 and GeO2 is 1025°± 1h0°C at about 96.8 wt% GeO2 ; the eutectic temperature between the 1:7 and 3:8 compounds is 935°± 10°C at about 90.9 wt% GeO2 ; the eutectic temperature between the 3:8 and 1:1 compounds is 930°± 10 °C at about 89.8 wt% GeO2 . Liquidus data for compositions richer in lithia than the 1:1 compound are only approximate because of the difficulty of quenching them; the phase relations between the 1:1 and 3:2 and between the 3:2 and 2:l compounds, however, are found to be of the simple binary eutectic type. The glass–forming region was also determined. Melts allowed to cool in air crystallized. When, however, the melts were quenched, glasses containing as much as 8 wt% GeO2 could be prepared in 5–g quantities. Both the refractive index–composition and density–composition curves for the glasses showed maxi–mums at about 6 to 8 wt% Li2 O. 相似文献
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T. André V. Lévesque V. Hayward P. Lefèvre J.-L. Thonnard 《Journal of the Royal Society Interface》2011,8(64):1574-1583
The dynamics of fingertip contact manifest themselves in the complex skin movements observed during the transition from a stuck state to a fully developed slip. While investigating this transition, we found that it depended on skin hydration. To quantify this dependency, we asked subjects to slide their index fingertip on a glass surface while keeping the normal component of the interaction force constant with the help of visual feedback. Skin deformation inside the contact region was imaged with an optical apparatus that allowed us to quantify the relative sizes of the slipping and sticking regions. The ratio of the stuck skin area to the total contact area decreased linearly from 1 to 0 when the tangential force component increased from 0 to a maximum. The slope of this relationship was inversely correlated to the normal force component. The skin hydration level dramatically affected the dynamics of the contact encapsulated in the course of evolution from sticking to slipping. The specific effect was to reduce the tendency of a contact to slip, regardless of the variations of the coefficient of friction. Since grips were more unstable under dry skin conditions, our results suggest that the nervous system responds to dry skin by exaggerated grip forces that cannot be simply explained by a change in the coefficient of friction. 相似文献
26.
Killen Joel D.; Fortmann Stephen P.; Murphy Greer M. Jr.; Hayward Chris; Arredondo Christina; Cromp DeAnn; Celio Maria; Abe Laurie; Wang Yun; Schatzberg Alan F. 《Canadian Metallurgical Quarterly》2006,74(2):286
The authors present results of a randomized clinical trial of the efficacy of extended treatment with bupropion SR in producing longer term cigarette smoking cessation. Adult smokers (N = 362) received open-label treatment (11 weeks) that combined relapse prevention training, bupropion SR, and nicotine patch followed by extended treatment (14 weeks) with bupropion SR or matching placebo. Abstinence percentages were relatively high (week 11: 52%; week 25: bupropion, 42%; placebo, 38%; week 52: bupropion, 33%; placebo, 34%), but bupropion SR did not surpass placebo. Gender and baseline craving level were identified as significant, independent moderators of treatment response. Men were more likely to abstain than women (week 11: 59% vs. 43%, p = .001; week 25: 48% vs. 31%, p = .001; week 52: 39% vs. 27%, p = .01). Because most smokers suffer relapse with any current cessation treatment, the comparatively high abstinence percentages achieved in this trial are of interest. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
27.
Hayward G 《Accident; analysis and prevention》2000,32(3):329-335
This paper provides a review of a selection of recent papers, most of which derive from presentations given at the 4th World Conference on Injury Prevention and Control or the 6th International Conference on Product Safety Research, both of which took place in Amsterdam in May 1998. What all the accidents studied in these papers have in common is the absence of professional supervision. Everyone immediately involved in the incident--whether as injured party, unintended cause or informal supervisor is an 'amateur'. It is proposed that the term 'domestic and personal accidents' should be used to describe this group of accidents, the study of which has been neglected in comparison to transport and occupational injuries. It is argued that domestic and personal activities are more heterogeneous than ones with an element of professional supervision and are therefore more difficult to prevent. Nevertheless examples are given of where 'horizontal' approaches to analysis and prevention of these accidents have proved possible. 相似文献
28.
Heat inactivation of hepatitis A virus in dairy foods 总被引:4,自引:0,他引:4
Experiments were performed to determine the thermal resistance of hepatitis A virus (HAV) in three types of dairy products containing increased amounts of fat content (skim milk, homogenized milk; 3.5% MFG, and table cream; 18% MFG). HAV-inoculated dairy products were introduced into custom-made U-shaped microcapillary tubes that in turn were simultaneously immersed in a waterbath, using custom-made floating boats and a carrying platform. Following exposure to the desired time and temperature combinations, the contents of each of the tubes was retrieved and was tested by plaque assay to determine the reduction in virus titer. Our data indicated that < 0.5 min at 85 degrees C was sufficient to cause a 5-log reduction in HAV titer in all three dairy products, whereas at 80 degrees C, < or = 0.68 min (for skim and homogenized milk), and 1.24 min (for cream) were needed to cause a similar log reduction. Using a nonlinear two-phase negative exponential model (two-compartment model) to analyze the data, it was found that at temperatures of 65, 67, 69, 71, and 75 degrees C, significantly (P < 0.05) higher exposure times were needed to achieve a 1-log reduction in virus titer in cream, as compared to skim and homogenized milk. For example, at 71 degrees C, a significantly (P < 0.05) higher exposure time of 0.52 min (for cream) was needed as compared to < or = 0.18 min (for skim and homogenized milk) to achieve a 1-log reduction in virus titer. A similar trend of inactivation was observed at 73 and 75 degrees C where significantly (P < 0.05) higher exposure times of 0.29 to 0.36 min for cream were needed to cause a 1-log reduction in HAV in cream, as compared to < or = 0.17 min for skim and homogenized milk. This study has provided information on the heat resistance of HAV in skim milk, homogenized milk, and table cream and demonstrated that an increase in fat content appears to play a protective role and contributes to the heat stability of HAV. 相似文献
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30.
AC Ward MH Hermans L Smith YM van Aesch AM Schelen C Antonissen IP Touw 《Canadian Metallurgical Quarterly》1999,93(1):113-124
The granulocyte colony-stimulating factor receptor (G-CSF-R) activates multiple STAT proteins. Although the membrane-proximal cytoplasmic region of the G-CSF-R is necessary and sufficient for activation of STAT1 and STAT5, activation of STAT3 requires the membrane distal region that contains four tyrosines. Although one of these (Y704) has previously been shown to be involved in STAT3 activation from a truncated G-CSF-R derived from a patient with severe chronic neutropenia (SCN), this tyrosine is not required for STAT3 activation by the full-length G-CSF-R. To investigate possible alternative mechanisms of STAT3 activation, we generated a series of Ba/F3 cell transfectants expressing the wild-type G-CSF-R or mutant receptors that either completely lack tyrosines or retain just one of the four cytoplasmic tyrosines of the G-CSF-R. We show that, at saturating G-CSF concentrations, STAT3 activation from the full-length G-CSF-R is efficiently mediated by the C-terminal domain in a manner independent of receptor tyrosines. In contrast, at low G-CSF concentrations, Y704 and Y744 of the G-CSF-R play a major role in STAT3 activation. Both tyrosine-dependent and -independent mechanisms of STAT3 activation are sensitive to the Jak2 inhibitor AG-490, follow similar kinetics, and lead to transactivation of a STAT3 reporter construct, indicating functional equivalence. STAT3 activation is also impaired, particularly at nonsaturating G-CSF concentrations, in bone marrow cells from mice expressing a truncated G-CSF-R (gcsfr-triangle up715). These findings suggest that G-CSF-induced STAT3 activation during basal granulopoiesis (low G-CSF) and "emergency" granulopoiesis (high G-CSF) are differentially controlled. In addition, the data establish the importance of the G-CSF-R C-terminus in STAT3 activation in primary cells, which has implications for understanding why truncated G-CSF-R derived from SCN patients are defective in maturation signaling. 相似文献