Simulation and optimization of retention in ion chromatography using virtual column 2 software

A new software package, Virtual Column 2, is described for the simulation and optimization of the separation of inorganic anions by ion chromatography (IC). The software uses a limited amount of experimental retention data acquired according to a correct experimental design to predict retention times for analytes over a designated search area of eluent compositions. The experimental retention data are used to solve a new retention model, called the linear solvent strength model, empirical approach (LSSM-EA), which then enables prediction of retention times for all eluent compositions in the search area. The theoretical development of LSSM-EA and the processes used for solving the equations are discussed. Virtual Column 2 can be used for eluents containing one or two competing ions, and the software contains retention databases for up to 33 analytes on the Dionex AS9A-HC, AS4A-SC, and AS14A analytical columns with carbonate-bicarbonate eluents and the Dionex AS10, AS15, and AS16 analytical columns with hydroxide eluents (results for the AS10 and AS15 columns are not discussed in the present study). Virtual Column 2 has been evaluated extensively and is shown to give predicted retention times that in most cases agree with experimentally determined data to within 5%. The software has uses in practical IC method development, education and training in IC, and refinement of existing IC methodology. A free version of this program is available by download at www.virtualcolumn.com.     

An Efficient Mobile Data Gathering Method with Tree Clustering Algorithm in Wireless Sensor Networks Balanced and Unbalanced Topologies

Wireless Personal Communications - Electroencephalography (EEG) is a technique of Electrophysiology used in a wide variety of scientific studies and applications. Inadequately, many commercial...     

Design, modeling, and characterization of monolithically integratedInP-based (1.55 μm) high-speed (24 Gb/s) p-i-n/HBT front-endphotoreceivers

High-speed, long-wavelength InAlAs/InGaAs OEIC photoreceivers based on a p-i-n/HBT shared layer integration scheme have been designed, fabricated and characterized. The p-i-n photodiodes, formed with the 6000 Å-thick InGaAs precollector layer of the HBT as the absorbing layer, exhibited a responsivity of ~0.4 A/W and a -3 dB optical bandwidth larger than 20 GHz at λ=1.55 μm. The fabricated three-stage transimpedance amplifier with a feedback resistor of 550 Ω demonstrated a transimpedance gain of 46 dBΩ and a -3 dB bandwidth of 20 GHz. The monolithically integrated photoreceiver with a 83 μm p-i-n photodiode consumed a small dc power of 35 mW and demonstrated a measured -3 dB optical bandwidth of 19.5 GHz, which is the highest reported to date for an InAlAs/InGaAs integrated front-end photoreceiver. The OEIC photoreceiver also has a measured input optical dynamic range of 20 dB. The performance of individual devices and integrated circuits was also investigated through detailed CAD-based analysis and characterization. Transient simulations, based on a HSPICE circuit model and previous measurements of eye diagrams for a NRZ 2³¹-1 pseudorandom binary sequence (PRBS), show that the OEIC photoreceiver is capable of operation up to 24 Gb/s     

Dissipative H2/H∞ controller synthesis

In certain applications, such as the colocated control of flexible structures, the plant is known to be positive real. Hence, closed-loop stability is unconditionally guaranteed as long as the controller is also positive real. One approach to designing positive real controllers is the LQG-based positive real synthesis technique of Lozano-Leal and Joshi. The contribution of this paper is the extension of this positive real synthesis technique to include an H_∞-norm constraint on closed-loop performance     

A study of cerebral perfusion using single photon emission computed tomography in neonates with brain lesions

In this study we used a single photon emission computed tomography technique (SPECT) with radiolabelled 99mTcHMPAO to assess cerebral perfusion in newborn infants with documented cerebral lesions and to determine to what extent brain SPECT might be useful in the neonatal period. A total of 15 newborn infants with the following cerebral pathologies were enrolled: severe parietal bilateral periventricular leucomalacia (PVL, n = 6); moderate parietal bilateral PVL (n = 2); intraventricular haemorrhage grade II with unilateral parietal parenchymal extension (IHV + PE, n = 3); cerebral infarction (CI, n = 2) in the zone of middle cerebral artery; and post-haemorrhagic hydrocephalus (n = 2). Follow-up was available in all infants. Alterations in cerebral perfusion were seen in only 12 of 15 infants and at the location of severe PVL, PE and CI. We have noted that the regions of diminished perfusion extended beyond the apparent extent of cerebral pathology delineated by ultrasound or magnetic resonance imaging. Markedly diminished perfusion was seen in 1 infant with hydrocephalus, which recovered following placement of ventriculo-peritoneal shunt. Regarding outcome, SPECT data failed to provide additional information than that of neuroradiological investigations. We conclude that the use of SPECT, under these conditions, to assess alteration of cerebral perfusion in the neonatal period will not provide any additional information than that of neuroradiological investigations.     

Filtering image records using wavelets and the Zakai equation

Consider the problem of detecting and localizing a faint object moving in an “essentially stationary” background, using a sequence of 2D low S/N ratio images of the scene. A natural approach consists of “digitizing” each snapshot into a discrete set of observations, sufficiently (perhaps not exactly) matched to the object in question, then tracking the object using an appropriate stochastic filter. The tracking would be expected to make up for the low S/N ratio, thus allowing one to “coherently” process successive images in order to beat down the noise and localize the object. The problem then becomes one of choosing the appropriate image representation as well as the optimal (and necessarily nonlinear) filter. We propose exact and approximate solutions using wavelets and the Zakai equation. The smoothness of the wavelets used is required in the derivation of the evolution equation for the conditional density giving the filter, and their orthogonality makes it possible to carry out actual computations of the Ito- and change-of-gauge-terms in the algorithm effectively     

Breakdown voltage improvement in strained InGaAlAs/GaAs FETs

GaAs MESFETs with a surface layer of pseudomorphic InGaAlAs have been fabricated. The compressive strain and wide bandgap in the InGaAlAs layer reduce the impact ionization rate in this layer and improve the breakdown voltage of the device. A 1 μm×75 μm gate device with the pseudomorphic surface layer showed an improvement in gate-to-drain breakdown of over 55% and an improvement in channel breakdown of 50% as compared to a similar device without the pseudomorphic layer. Both devices had a peak transconductance of about 190 mS/mm and a saturation current of about 265 mA/mm     

Mechanistic Studies on the [2 + 2] Photocycloaddition of Deuterium-Labeled Olefins

The mechanism of intramolecular [2 + 2] photocycloaddition of 1b has been investigated. Structure determination of deuterium-labeled photoadducts was accomplished by ²H NMR.     

Laparoscopy for the impalpable testes. Initial experience of one center

Endoscopic treatment of acute pancreatitis has been proposed in different conditions: acute biliary pancreatitis, pancreatitis related to pancreas divisum or in case of pseudocysts. The efficacy of such endoscopic procedure is discussed.