Single agent activity of rhizoxin in non-small-cell lung cancer: a phase II trial of the EORTC Early Clinical Trials Group

In a multicentre trial of the EORTC-Early Clinical Trials Group (ECTG) we treated 31 chemotherapy-naive patients with advanced non-small-cell lung cancer (NSCLC) with rhizoxin, a novel tubulin-binding agent. The drug was given as an i.v. bolus injection at 2 mg m-2 once every 3 weeks in an outpatient setting. Prophylactic antiemetics were not routinely given. Of the 29 eligible patients, nine had been treated surgically and three had received radiotherapy. The main toxic effects observed were stomatitis (34% of cycles) and neutropenia (41% of cycles). Neutropenic fever was rare (3% of cycles). Twenty-seven patients were evaluable for response. There were four partial responses (15%), while 13 patients (48%) showed stabilisation of their disease. The median duration of response was 7 months (range 6.0-10.7 months) and median survival from the start of rhizoxin treatment was 6 months (range 2-14.7 months). Rhizoxin as single agent shows activity in patients with advanced NSCLC.     

Dye-Fibre Bond Stabilities of Some Reactive Dyes on Silk

57th Communication on Investigations in Textile Chemistry, for 56th Communication see ref. J. Silk was dyed with twelve reactive dyes containing various reactive groups. The dyeings were thoroughly extracted so that all non-covalently bonded dye was removed. The extracted dyeings were treated with buffer solutions in the pH range 1.89 to 10.65 at 70°C for 24 h. The exhaustion, fixation ratio and extent of reaction of the dyeings and the rate of hydrolysis of all dyed samples in six buffers were measured. The dye-fibre bond was found to be sufficiently resistant to hydrolysis for ail dyeings. The fixation ratio and wet fastness were particularly good for dyeings with α-bromoacrylamide groups and with difluorochloropyrimidine groups.     

Ermittlung der zum Überlaufen von Sauerstoffaufblaskonvertern führenden Aufblasgeschwindigkeiten sowie der Größe fluider Partikeln in Gasströmen

Analogien zwischen dem Schäumen im Sauerstoffaufblaskonverter und dem Verhalten von Wirbelschichten. Quantitative Untersuchung der Höhe der Schaumschlacke. Aufstellung eines Nomogramms zur Ermittlung der Schaumschlackenhöhe bei Vorgabe der Sauerstoffaufblasgeschwindigkeit oder umgekehrt. Angabe von Maßnahmen zur Verminderung der Gefahr des Überlaufens. Abschätzung der Partikelabmessungen unter Berücksichtigung von Gasströmen als Zerkleinerungsmittel. Erörterung des Einflusses des entweichenden Kohlenmonoxids auf die Größe der fluiden Tropfen in der Schaumschlacke. Aussagen über bei Blasbeginn durch den Sauerstoffstrahl erzeugte Partikeln, deren Größe mit denen des braunen Rauches vergleichbar ist. Die Erzeugung der ?richtigen? Größe der Fluidpartikeln in der Schaumschlacke als Optimierungsproblem.     

Untersuchungen zur Analogie zwischen Wärme- und Impulsaustausch bei der Kondensation in rotierenden Trockenzylindern

Zusammenfassung Ausgehend von jenen Ans?tzen, dieStuart verwendet hat, um den durch Taylor-G?rtler-Wirbel verbesserten Impulstransport im Ringspalt zweier koaxial instabil rotierender Zylinder zu beschreiben, wird auch der verbesserte W?rmetransport berechnet. Die Arbeit zeigt, wie man die daraus hergeleitete Analogiebeziehung in davon durchaus abweichenden F?llen anwenden kann: Obwohl der frei schwingende Kondensatfilm in einer rotierenden Trockentrommel nur lokal instabil geschichtet ist, zeigen sich geschlossene Taylor-G?rtler-Wirbel. Aus experimentellen Untersuchungen der Filmdickenverteilung des isothermen Filmes kann die Verbesserung des W?rmeüberganges abgelesen werden. Herrn Professor Dr.-Ing. Dr.-Ing. E.h.Hans Dieter Baehr zum 60. Geburtstag gewidmet Vorgetragen auf der GVC-Jahrestagung W?rme- und Stoffaustausch 1986 in Bad S?ckingen.     

Das verhalten von copolymeren aus styrol und acenaphthylen bei der einwirkung von licht,I

A series of styrene and acenaphthylene copolymers were prepared by thermal polymerization at 100°C. Films of copolymers with various contents of acenaphthylene were exposed to light in an apparatus (Xenotest) under the atmosphere of normal air and in some cases under nitrogen. The degradation of copolymers was followed by measurements of solution viscosity. Copolymers with small contents of acenaphthylene (4,2 mol-%) show slower degradation than polystyrene up to exposure times of about 80 h, but then a stronger degradation takes place with increased content of acenaphthylene. In the presence of oxygen the formation of benzene-insoluble particles besides degradation was observed. The amount of these “benzene-insoluble” particles, which have a specific absorption in the infrared at 1730 cm ^–1, depends upon the exposure time and the content of acenaphthylene. No such benzene-insoluble products were found if the films were exposed to light in the same apparatus under nitrogen atmosphere.