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61.
BM Chen LY Chan SM Wang MF Wu JW Chern SR Roffler 《Canadian Metallurgical Quarterly》1997,73(3):392-402
We examined the in vivo efficacy of targeting beta-glucuronidase (betaG) to activate a glucuronide prodrug (BHAMG) of p-hydroxyaniline mustard (pHAM) at hepatoma ascites in Sprague-Dawley rats. Injection i.p. of 500 microg RH1-betaG, a conjugate formed between recombinant betaG and monoclonal antibody RH1 with specificity for an antigen expressed on AS-30D rat hepatoma cells, into rats bearing AS-30D ascites resulted in the accumulation of 54 microg conjugate per 10(9) tumor cells after 2 hr. Ascites fluid and serum contained 0.53 and 0 microg/ml, respectively, RH1-betaG 2 hr after injection of the conjugate. Conjugate binding to AS-30D cells was heterogeneous and non-saturated, as determined by flow cytometry. BHAMG was less toxic than pHAM to SD rats based on measures of animal mortality, weight loss and hematological toxicity. Treatment of rats bearing established hepatoma ascites with 500 microg RH1-betaG followed 2 hr later with a single i.p. injection of 30 mg/kg BHAMG or 3 i.p. injections of 10 mg/kg BHAMG 2, 3 and 4 hr later resulted in the cure of 6/8 and 8/8 animals, respectively. Treatment with BHAMG or pHAM alone did not produce cures, whereas treatment with a control antibody-betaG conjugate and BHAMG produced significantly greater hematological toxicity compared to treatment with RH1-betaG and BHAMG. All cured rats were completely protected from rechallenge with 2 x 10(7) AS-30D cells, indicating that successful treatment of animals induced protective immunity. 相似文献
62.
用实验方法研究了Al_2O_3陶瓷缺口试件在循环载荷作用下的疲劳寿命。结果表明,缺口导致的应力集中效应显著降低了循环疲劳寿命;若用缺口根部最大应力为应力水平,则不同缺口半径陶瓷试件具有相同疲劳断裂规律,说明陶瓷材料的疲劳集中系数和理论应力集中系数相同。本文还分析讨论了陶瓷材料的循环疲劳寿命表达式和循环疲劳断裂机理。 相似文献
63.
把瞬态记录仪Biomation8l00与微型计算机IBM─pC/XT联接建成了一个高速数据采集系统,本文介绍了系统的硬件接口设计及软件设计。在超声分子束条件下,把它应用于环氧乙烷(C_2H_4O)的多光子电离与离解飞行时间(MPID─TOF)质谱的实验研究中,并给出了实验结果;本系统在微观基元化学反应动力学实验研究中广泛适用于对时间分辨微弱信号的探测。 相似文献
64.
Jan van Eijck 《Formal Aspects of Computing》1994,6(1):766-787
Presuppositions of utterances are the pieces of information you convey with an utterance no matter whether your utterance is true or not. We first study presupposition in a very simple framework of updating propositional information, with examples of how presuppositions of complex propositional updates can be calculated. Next we move on to presuppositions and quantification, in the context of a dynamic version of predicate logic, suitably modified to allow for presupposition failure. In both the propositional and the quantificational case, presupposition failure can be viewed as error abortion of procedures. Thus, a dynamic assertion logic which describes the preconditions for error abortion is the suitable tool for analysing presupposition. 相似文献
65.
66.
Weight smoothing to improve network generalization 总被引:2,自引:0,他引:2
A weight smoothing algorithm is proposed in this paper to improve a neural network's generalization capability. The algorithm can be used when the data patterns to be classified are presented on an n-dimensional grid (n>/=1) and there exists some correlations among neighboring data points within a pattern. For a fully-interconnected feedforward net, no such correlation information is embedded into the architecture. Consequently, the correlations can only be extracted through sufficient amount of network training. With the proposed algorithm, a smoothing constraint is incorporated into the objective function of backpropagation to reflect the neighborhood correlations and to seek those solutions that have smooth connection weights. Experiments were performed on problems of waveform classification, multifont alphanumeric character recognition, and handwritten numeral recognition. The results indicate that (1) networks trained with the algorithm do have smooth connection weights, and (2) they generalize better. 相似文献
67.
利用TM资料测量毛乌素沙地面积的方法和结果 总被引:1,自引:0,他引:1
利用1:25万陆地卫星TM资料和地形图,在GIS支持下,建立毛乌素沙地图形数据库,对毛乌素沙地目前流沙分布的范围进行了调查研究。重.资、介绍了利用陆地卫星TM资料对毛乌素沙地的面积进行测童计算的技术和方法,给出了最新测贡得到的毛乌素沙地全区总面积和分布于各旗县的沙地面积数据。 相似文献
68.
Shouhong Wang 《Information Systems Management》1994,11(2):36-43
Business reengineering requires new systems analysis tools for process modeling. An object-oriented (OO) approach may be better than the traditional data flow diagram method in modeling business processes. This article explains the development of an OO tool that may potentially benefit IS in reengineering business processes. 相似文献
69.
EEPROM的参数设置控制着系统的基本功能,设置的改变对系统的起动和运行起着重要作用。本文详细地列出了EEPROM的地址分配表,并通过上机实验对那些重要的地址了详细的说明。 相似文献
70.
The preembedding double immunoreaction method was used to study interrelations of enkephalinergic and GABAergic neuronal elements in the dorsal raphe nucleus of the Wistar albino rat. The enkephalin-like neuronal elements were immunoreacted by the peroxidase-antiperoxidase method and silver-gold intensified, which showed strongly and was specific. The GABA-like immunoreactive neurons were immunoreacted by the peroxidase-antiperoxidase method only. GABA-like neural somata were postsynaptic to both the enkephalin-like immunoreactive and the non-immunoreactive axon terminals. The enkephalin-like immunoreactive axon terminals were also found to synapse GABA-like immunoreactive dendrites. The GABA-like immunoreactive neuronal elements were also found to receive synapses from other non-immunoreactive as well as GABA-like immunoreactive axon terminals. Almost all of the synapses appeared to be asymmetrical. Possible functional activity of interactions among the enkephalinergic, GABAergic, and serotonergic neuronal elements in the dorsal raphe nucleus are discussed. 相似文献