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61.
Linda Kwai-Lin Lau Rajeev Jain Henry Samueli Henry T. Nicholas III Etan G. Cohen 《The Journal of VLSI Signal Processing》1992,4(2-3):213-226
This paper presents a functional compiler for the automatic design of Direct Digital Frequency Synthesizer (DDFS) integrated circuits (ICs) using a ROM based table look-up architecture. The compiler allows the user to specify high-level specifications such as the acceptable spurious response and it generates the IC architecture, floorplan, and layout. To construct the layout for different specifications, a library of parameterized macrocells has been developed in 1.2 m CMOS technology.A test chip with a quadrature DDFS module has been generated, using the compiler, and fabricated. The chip has two input signals: one is for frequency control while the other is for phase initialization. Input and output word lengths are 16 bits and 6 bits respectively. The chip complexity is approximately 12,000 transistors (DDFS core) and the die size is 4.8×2.9mm
2. A maximum sample rate of 80 MHz has been attained implying a maximum sine (cosine) output frequency of 40 MHz and a frequency resolution of 1.22 kHz. The maximum spurious level measured is –46 dB. 相似文献
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65.
Kin Kit Fong Inn Shi Tan Henry Chee Yew Foo Man Kee Lam Adrian Chiong Yuh Tiong Steven Lim 《中国化学工程学报》2021,33(5):297-305
The rising production of produced water from oilfields had been proven to bring detrimental environmental effects. In this study, an efficient, recyclable, and environmental-friendly reduced graphene oxide immobilized κ-Carrageenan hydrogel composite(κCa GO) was fabricated as an alternative sorbent for crude oil-in-water demulsification. Polyethyleneimine(PEI) was employed to form a stable hydrogel composite. The conditions for the immobilization of graphene oxide(GO) on PEI-modified κ-Carrageenan(κC) beads were optimized appropriately. An immobilization yield of 77% was attained at 2% PEI, 2 h immobilization activation time, and p H6.5. Moreover, the synthesized κCa GO is capable of demulsification with an average demulsification efficiency of 70%. It was found that the demulsification efficiency increases with salinity and κCa GO dosage, and it deteriorates under alkaline condition. These phenomena can be attributed to the interfacial interactions between κCa GO and the emulsion. Furthermore, the κCa GO can be recycled to use for up to six cycles without significant leaching and degradation. As such, the synthesized κCa GO could be further developed as a potential sorbent substitute for the separation of crude oil from produced water. 相似文献
66.
Alon M. Douek Mitra Amiri Khabooshan Jason Henry Sebastian-Alexander Stamatis Florian Kreuder Georg Ramm Minna-Liisa nk Donald Wlodkowic Jan Kaslin 《International journal of molecular sciences》2021,22(11)
Mucopolysaccharidosis IIIA (MPS IIIA, Sanfilippo syndrome type A), a paediatric neurological lysosomal storage disease, is caused by impaired function of the enzyme N-sulfoglucosamine sulfohydrolase (SGSH) resulting in impaired catabolism of heparan sulfate glycosaminoglycan (HS GAG) and its accumulation in tissues. MPS IIIA represents a significant proportion of childhood dementias. This condition generally leads to patient death in the teenage years, yet no effective therapy exists for MPS IIIA and a complete understanding of the mechanisms of MPS IIIA pathogenesis is lacking. Here, we employ targeted CRISPR/Cas9 mutagenesis to generate a model of MPS IIIA in the zebrafish, a model organism with strong genetic tractability and amenity for high-throughput screening. The sgshΔex5−6 zebrafish mutant exhibits a complete absence of Sgsh enzymatic activity, leading to progressive accumulation of HS degradation products with age. sgshΔex5−6 zebrafish faithfully recapitulate diverse CNS-specific features of MPS IIIA, including neuronal lysosomal overabundance, complex behavioural phenotypes, and profound, lifelong neuroinflammation. We further demonstrate that neuroinflammation in sgshΔex5−6 zebrafish is largely dependent on interleukin-1β and can be attenuated via the pharmacological inhibition of Caspase-1, which partially rescues behavioural abnormalities in sgshΔex5−6 mutant larvae in a context-dependent manner. We expect the sgshΔex5−6 zebrafish mutant to be a valuable resource in gaining a better understanding of MPS IIIA pathobiology towards the development of timely and effective therapeutic interventions. 相似文献
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68.
船舶用碳钢表面镀Zn及其耐蚀性 总被引:4,自引:0,他引:4
为了提高船舶舱内碳钢制品的使用寿命,以20#碳钢 为例对其表面采用无氨、无氰溶液镀Zn以及钝化处理.研究了镀Zn试样在中性盐雾以及含有 机物质气氛中的耐蚀性能.结果表明:有机物质气氛是造成船舶舱内碳钢制品腐蚀的主要 原因,而无氨、无氰溶液进行镀Zn能在很大程度上解决碳钢表面的电化学腐蚀问题. 相似文献
69.
Finite-element simulation of induction heat treatment 总被引:2,自引:0,他引:2
K. F. Wang S. Chandrasekar Henry T. Y. Yang 《Journal of Materials Engineering and Performance》1992,1(1):97-112
An efficient finite-element procedure has been developed for the analysis of induction heat treatment problems involving nonisothermal
phase changes. The finite-element procedure first simulates the magnetic field developed when currents flow through an induction
coil by solving Maxwell’s electromagnetic field equations; at the following step, it calculates the temperature distribution
in the workpiece due to eddy currents induced by the magnetic field. The final stage of the simulation involves the determination
of the distributions of residual stress, hardness, and microstructure in the workpiece. The finite-element analysis includes
temperature-dependent material properties, changes in permeability of the workpiece at the Curie temperature, a mixed hardening
rule to describe the material constitutive model, and the incorporation of time-temperature-transformation (TTT) diagram. The procedure was applied to the simulation of the induction hardening of 1080 steel bar. Firstly, the magnetic
field and temperatures developed in the workpiece during (a) the induction heating of an infinitely long 1080 steel cylinder
by a single encircling coil and (b) the induction heating of a semi-infinite half-space by a single coil suspended above it
were calculated using the finite-element procedures. These were validated by comparing them with analytical solutions derived
for these configurations using a Green’s function method. Finally, to demonstrate the predictive capability and practical
applicability of the current finite-element procedure, two examples pertaining to the induction heat treatment of an infinite
1080 steel bar of square cross section and a notched finite 1080 steel cylinder of circular cross section were analyzed to
predict the magnetic field, temperature, and residual stress distributions. The current finite-element procedure could be
used as a powerful design tool for linking induction heat treating parameters with the mechanical property attributes of the
heat treated component. 相似文献
70.
The mechanical property and phase structures of wheat proteins/polyvinyl alcohol blends studied by high-resolution solid-state NMR 总被引:1,自引:0,他引:1
The phase structures of thermally processed wheat proteins (WP) and polyvinyl alcohol (PVOH) blends were studied by solid-state high-resolution NMR spectroscopy. The intermolecular interactions among the multi-component systems and the behavior of each component in the blends on scales of nanometers were examined. The mechanical properties of the blends were also measured and related to the phase structure studies. The results indicated that the polymer chains of WP could be homogeneously mobilized when thermally processed with glycerol and water as plasticisers, but the glycerol predominately associated with WP rather than PVOH in the blends. The intermolecular hydrogen bonding interactions between WP and PVOH caused some extent of miscibility in the system on scales of nanometers especially when the PVOH content was low. The tensile strength and modulus of the blends were improved as compared to WP. However, the intermolecular interactions were relatively weak and could not be further enhanced by increasing PVOH component in the blends. The particle miscible WP/PVOH blends contained plasticised WP and PVOH phases in conjunction with the miscible WP/PVOH phase. Increasing the PVOH content in the blends did not result in an increase of the percentage of the miscible phase and the blends tented to be immiscible while the elongation of the blends was reduced when increasing the PVOH content in the blends. 相似文献