Burden and cost of gastroenteritis in a Canadian community

This study estimated the health burden and costs associated with gastroenteritis in the City of Hamilton (Ontario, Canada). The number of cases, number of different resource units used, and cost per resource unit were represented by probability distributions and point estimates. These were subsequently integrated in a stochastic model to estimate the overall burden and cost in the population and to depict the uncertainty of the estimates. The estimated mean annual cost per capita was Can dollar 115. The estimated mean annual cost per case was Can dollar 1,089 and was similar to other published figures. Gastroenteritis represented a significant burden in the study population, with costs high enough to justify prevention efforts. These results, currently the most accurate available estimates for a Canadian population, can inform future economic evaluations to determine the most cost effective measures for reducing the burden and cost of gastroenteritis in the community.     

Matrix-assisted laser desorption/ionization-ion mobility separation-mass spectrometry imaging of vinblastine in whole body tissue sections

During early-stage drug development, drug and metabolite distribution studies are carried out in animal tissues using a range of techniques, particularly whole body autoradiography (WBA). While widely employed, WBA has a number of limitations, including the following: expensive synthesis of radiolabeled drugs and analyte specificity and identification. WBA only images the radiolabel. MALDI MSI has been shown previously to be advantageous for imaging the distribution of a range of drugs and metabolites in whole body sections. Ion mobility separation (IMS) adds a further separation step to imaging experiments; demonstrated here is MALDI-IMS-MS whole body imaging of rats dosed at 6 mg/kg i.v. with an anticancer drug, vinblastine and shown is the distribution of the precursor ion m/z 811.4 and several product ions including m/z 793, 751, 733, 719, 691, 649, 524, and 355. The distribution of vinblastine within the ventricles of the brain is also depicted. Clearly demonstrated in these data are the removal of interfering isobaric ions within the images of m/z 811.4 and also of the transition m/z 811-751, resulting in a higher confidence in the imaging data. Within this work, IMS has shown to be advantageous in both MS and MS/MS imaging experiments by separating vinblastine from an endogenous isobaric lipid.     

Program development in the constructive set theory TK

We present a constructive theory of types and kinds designed with program development as the major desideratum. We show how this theory may be employed to derive programs from proofs of specifications (that is, demonstrations that specifications are satisfiable) and how the infrastructure of the theory supports the transformational development of programs in a natural way.     

Analysis of a diamond-shaped mechanical amplifier for a piezo actuator

Piezo actuators can produce high precision mechanical movement. The problem is that they can only produce very limited displacement. This paper firstly reviews the different mechanical amplifier mechanisms that increase the displacement of the piezo actuator. A mechanical analysis for one mechanism, the diamond shaped mechanical amplifier, is presented. The key design parameters of a prototype diamond amplifier for use in pneumatic valves are detailed. The results of testing the amplifier are given and compared with the theory. It is found that the displacement of the prototype amplifier does not deviate more than 7% from the theoretical value.     

Red light running and close following behaviour at urban shuttle-lane roadworks

Roadworks (work zones) are a common feature of our urban environment. They have a considerable impact on reducing roadway capacity, causing interruptions and imposing substantial delays to road users, which in turn adds to the cost to society and adverse impact on road safety. Shuttle-lane (alternate one-way working) is one of the most commonly used traffic management arrangements at urban roadworks as most of the urban road network is built up from single carriageway.     

Girls' relationship authenticity and self-esteem across adolescence.

Feminist psychologists have long posited that relationship authenticity (i.e., the congruence between what one thinks and feels and what one does and says in relational contexts) is integral to self-esteem and well-being. Guided by a feminist developmental framework, the authors investigated the role of relationship authenticity in promoting girls' self-esteem over the course of adolescence. Latent growth curve modeling was used to test the association between relationship authenticity and self-esteem with data from a 5-year, 3-wave longitudinal study of 183 adolescent girls. Results revealed that both relationship authenticity and self-esteem increased steadily in a linear fashion from the 8th to the 12th grade. Girls who scored high on the measure of relationship authenticity in the 8th grade experienced greater increases in self-esteem over the course of adolescence than girls who scored low on relationship authenticity. Further, girls who increased in authenticity also tended to increase in self-esteem over the course of adolescence. The importance of a feminist developmental framework for identifying and understanding salient dimensions of female adolescence is discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Semantic Provenance for eScience: Managing the Deluge of Scientific Data

Provenance information in eScience is metadata that's critical to effectively manage the exponentially increasing volumes of scientific data from industrial-scale experiment protocols. Semantic provenance, based on domain-specific provenance ontologies, lets software applications unambiguously interpret data in the correct context. The semantic provenance framework for eScience data comprises expressive provenance information and domain-specific provenance ontologies and applies this information to data management. The authors' "two degrees of separation" approach advocates the creation of high-quality provenance information using specialized services. In contrast to workflow engines generating provenance information as a core functionality, the specialized provenance services are integrated into a scientific workflow on demand. This article describes an implementation of the semantic provenance framework for glycoproteomics.