Pelvic ring reconstruction with a vascularized bone flap of femur

Three patients developed acute colitis, either de novo, or as an exacerbation of pre-existing colitis, following the use of oral acyclovir, prescribed for Herpes zoster or Herpes simplex infection. Rechallenge with oral acyclovir was performed in one patient, and resulted in a recurrence of colitic symptoms. It is speculated that acyclovir can have a direct irritant effect on large bowel mucosa.     

A New Lead Identification Strategy: Screening an sp3-rich and Lead-like Compound Library Composed of 7-Azanorbornane Derivatives

Although the advantages of sp³-rich, sterically complicated molecules in drug development have been pointed out, modern screening libraries are filled with planar, sp²-rich components. Compounds that are sp³-rich are difficult to synthesize, and thus we aimed to invent an efficient method to construct sp³-rich libraries. By modifying sp³-rich 7-azanorbornane scaffolds through click chemistry, we efficiently prepared a small set of compounds. These compounds were not only sp³-rich, but also had sufficient “lead-like” properties in view of molecular weights and hydrophobicity. Screening assays of this library provided weak κ opioid receptor agonists and growth hormone secretagogue receptor agonists with high hit rates. These results indicate that the 7-azanorbornane scaffold may be a “privileged structure” for lead identification in drug discovery.     

Application of magnetic nanoparticles to gene delivery

Nanoparticle technology is being incorporated into many areas of molecular science and biomedicine. Because nanoparticles are small enough to enter almost all areas of the body, including the circulatory system and cells, they have been and continue to be exploited for basic biomedical research as well as clinical diagnostic and therapeutic applications. For example, nanoparticles hold great promise for enabling gene therapy to reach its full potential by facilitating targeted delivery of DNA into tissues and cells. Substantial progress has been made in binding DNA to nanoparticles and controlling the behavior of these complexes. In this article, we review research on binding DNAs to nanoparticles as well as our latest study on non-viral gene delivery using polyethylenimine-coated magnetic nanoparticles.     

Melt-mixing by novel pitched-tip kneading disks in a co-rotating twin-screw extruder

Melt-mixing in twin-screw extruders is a key process in the development of polymer composites. Quantifying the mixing performance of kneading elements based on their internal physical processes is a challenging problem. We discuss melt-mixing by novel kneading elements called “pitched-tip kneading disk (ptKD)”. The disk-stagger angle and tip angle are the main geometric parameters of the ptKDs. We investigated four typical arrangements of the ptKDs, which are forward and backward disk-staggers combined with forward and backward tips. Numerical simulations under a certain feed rate and screw revolution speed were performed, and the mixing process was investigated using Lagrangian statistics. It was found that the four types had different mixing characteristics, and their mixing processes were explained by the coupling effect of drag flow with the disk staggering and pitched-tip and pressure flows, which are controlled by operational conditions. The use of a pitched-tip effectively controls the balance of the pressurization and mixing ability.     

Production of silk sericin/silk fibroin blend nanofibers

Silk sericin (SS)/silk fibroin (SF) blend nanofibers have been produced by electrospinning in a binary SS/SF trifluoroacetic acid (TFA) solution system, which was prepared by mixing 20 wt.% SS TFA solution and 10 wt.% SF TFA solution to give different compositions. The diameters of the SS/SF nanofibers ranged from 33 to 837 nm, and they showed a round cross section. The surface of the SS/SF nanofibers was smooth, and the fibers possessed a bead-free structure. The average diameters of the SS/SF (75/25, 50/50, and 25/75) blend nanofibers were much thicker than that of SS and SF nanofibers. The SS/SF (100/0, 75/25, and 50/50) blend nanofibers were easily dissolved in water, while the SS/SF (25/75 and 0/100) blend nanofibers could not be completely dissolved in water. The SS/SF blend nanofibers could not be completely dissolved in methanol. The SS/SF blend nanofibers were characterized by Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry, and differential thermal analysis. FTIR showed that the SS/SF blend nanofibers possessed a random coil conformation and ß-sheet structure.     

Derivation of equivalents for dynamic security assessment

A method is described by which the order of interconnected power systems is reduced. When the system under study is composed of a main system and several subsystems connected to the main system, the method gives an equivalent model to each subsystem with far fewer generators, even when each subsystem is connected to the main system at more than one point. The paper also discusses the data that needs to be sent from each subsystem when it is expressed by a reduced-order equivalent model. A numerical example of a 250-bus and 61-machine system shows that the method is effective and causes no loss of accuracy. Although the proposed method provides an accurate reduced-order model, it is rather time-consuming, because it is based on the linearized dynamic equations of the system, and their eigenvectors are needed. This problem must be solved before practical use of the method can proceed.     

Cylindrical linear pulse motor with interior permanent magnet mover

The advantages of the conventional cylindrical linear pulse motor (C-LPM), which has a ring permanent magnet between the A- and B-phase stators, are its simple magnet shape and small motor diameter; the disadvantages are the thrust imbalance resulting from the magnetic flux path of the outer poles being longer than that of the inner poles. This thrust imbalance decreases the pull-in thrust and increases the positioning error. In this paper, a new C-LPM with an interior permanent magnet mover which reduces this thrust imbalance is proposed. Steady and dynamic thrust are also examined and a magnetic equivalent circuit is discussed. It is shown that a C-LPM with an interior permanent magnet mover effectively improves the thrust imbalance and the dynamic thrust     

Wide-speed operation of interior permanent magnet synchronousmotors with high-performance current regulator

Interior permanent magnet synchronous motors can be applied to applications requiring wide-speed operation. The current vector control algorithm of an interior permanent magnet synchronous (IPM) motor for constant power operation over the base speed is proposed. As the available voltage controlling the armature current vector is small in the flux-weakening constant power region, the current vector sometimes becomes uncontrollable in transient operations because of the current regulator saturation. The high-performance current regulator is also proposed to improve the current responses in the flux-weakening region, which includes the decoupling current controller and the voltage command compensator. The control performances are confirmed by several drive tests with respect to the prototype IPM motor     

Electrical Properties of Silica-Based Nanocomposites with Multiwall Carbon Nanotubes

Fully dense multiwall carbon nanotubes (MWCNT)/SiO₂ nanocomposites with MWCNTs contents of 5 and 10 vol% have been processed by spark plasma sintering, and the electrical conductivities of the nanocomposites were evaluated at temperatures ranging from 5 to 300 K. It has been found that the incorporation of MWCNTs converted an insulating silica nanoceramic into metallically conductive composites. The room-temperature conductivities of the nanocomposites, with over 14 orders of magnitude compared with pure silica, are in the range of 8 and 65 S/m. Also, it was interestingly found that the conductivity increased linearly with temperature from 5 to 300 K.