Neuroelectric Mechanisms of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage

Delayed cerebral ischemia (DCI) remains a challenging but very important condition, because DCI is preventable and treatable for improving functional outcomes after aneurysmal subarachnoid hemorrhage (SAH). The pathologies underlying DCI are multifactorial. Classical approaches to DCI focus exclusively on preventing and treating the reduction of blood flow supply. However, recently, glutamate-mediated neuroelectric disruptions, such as excitotoxicity, cortical spreading depolarization and seizures, and epileptiform discharges, have been reported to occur in high frequencies in association with DCI development after SAH. Each of the neuroelectric disruptions can trigger the other, which augments metabolic demand. If increased metabolic demand exceeds the impaired blood supply, the mismatch leads to relative ischemia, resulting in DCI. The neuroelectric disruption also induces inverted vasoconstrictive neurovascular coupling in compromised brain tissues after SAH, causing DCI. Although glutamates and the receptors may play central roles in the development of excitotoxicity, cortical spreading ischemia and epileptic activity-related events, more studies are needed to clarify the pathophysiology and to develop novel therapeutic strategies for preventing or treating neuroelectric disruption-related DCI after SAH. This article reviews the recent advancement in research on neuroelectric disruption after SAH.     

A novel spherical carbon

We developed a novel spherical carbon material. The spherical carbon is composed of a high density of carbon nanotubes or nanofilaments, and includes an oxidized diamond particle as a core. Syntheses of this carbon in high volume with high selectivity may be possible. It is expected that this carbon will be useful as a catalyst material for fuel cells, electric double-layer capacitors, etc.     

Chemistry and melting characteristics of fireside deposits taken from boiler tubes in waste incinerators

Twenty-three tube deposits taken from seven heat-recovery boilers of municipal solid waste incinerators were examined by chemical analyses and X-ray diffraction. These deposits were measured by Differential Scanning Calorimeter (DSC) in N₂ to investigate their melting characteristics. Sixteen deposits were used to evaluate their corrosiveness to carbon steel by high-temperature corrosion test conducted at 400 °C for 20 h in 1500 ppm HCl – 300 ppm SO₂ – 7.5%O₂ – 7.5%CO₂ – 20%H₂O – N₂. Total heat of endothermic reactions of the deposits taking place between 200 and 400 °C can be related to the corrosion rate of carbon steel at 400 °C. Corrosion initiated at temperatures when the deposits started to melt, became severe when fused salt constituents increased, and alleviated when the majority of the deposits became fused. The corrosion can be interpreted as fused salt corrosion caused by chloride and sulfate salts.     

Evaluating a behavioral demand response trial in Japan: evidence from the summer of 2013

This paper presents results from a behavioral demand response trial targeted to both grid and residential peak hours, in which weekly feedback via paper-based reports, real-time feedback via an in-home display, 30-minute tiered rate, and email prompts are adopted to almost 230 residential customers of a condominium in Funabashi, a city located in Greater Tokyo. Through a randomized experiment, we find that the peak saving impact during grid peak hours (1–4 pm, weekdays only) was 11.6 %, given that all the four interventions provided all at once. In addition, the results show that the variation in peak saving effects by household characteristics exists, and the variation differs among packages of peak saving interventions. Furthermore, we analyzed how much informational elements in weekly reports are considered as useful by residential customers. These results suggest that feedback-based approaches for peak saving can promote households’ energy conservation behavior.     

Layered mixed-anion compounds: Epitaxial growth,active function exploration,and device application

Optoelectronic properties and device applications of layered mixed-anion compounds such as oxychalcogenide LaCuOCh (Ch = chalcogen) and oxypnictide LaT_MOPn (T_M = 3d transition metal, Pn = pnicogen) are reviewed. Several distinctive functions have been found in these materials based on our original material exploration concept. Fabrication of high-quality epitaxial films of LaCuOCh leads to clarifying the excellent electrical and optical properties such as high hole mobility of 8 cm²/(V s) and heavy hole doping at >10²¹ cm^?3 in LaCuOSe, and sharp and tunable-wavelength photoluminescence in the solid–solution systems in LaCuOCh. In addition, a room temperature operation of a light-emitting diode is demonstrated using LaCuOSe as a light-emitting layer. These results suggest that the layered oxychalcogenides have potential for light-emitting layers as well as transparent hole-injection layers in organic/inorganic light-emitting diodes. Furthermore, by extending the material system from the copper-based oxychalcogenides to isostructural compounds, transition metal-based oxypnictides LaT_MOP (T_M = Fe, Ni), we have found novel superconductors, LaFeOP and LaNiOP.     

Market micro-structure analysis by multiagent simulation in X-Economy -- comparison among technical indices

We are developing an agent and server library referred to as X-Economy, by which we can execute multiagent simulations and network games for financial and economic systems. To this end, we analyzed the characteristics of network games in a financial context and compared them with traditional ones. X-Economy has also provided a new research direction in market micro-structure analysis. We executed several kinds of multiagent simulations for technical traders (indices) and obtained non-trivial suggestions regarding the relationship between the market randomness and the effectiveness of technical indices. For instance, the performance of complex technical indices seemed to deeply depend on the characteristics and nature of a market when a market became complex, i.e. it moved far from the Wiener process.     

PID landing orbit motion controller for an indoor blimp robot

Blimp robots are attractive as indoor flying robots because they can float in the air, land safely with low energy, and stay in motion for a long time compared with other flying robots. However, controlling blimp robots is difficult because they have nonlinear characteristics, are influenced by air streams, and can easily be influenced by inertia. Therefore, a robust and adaptive control system is needed for blimp robots. The applied research that has studied the features of indoor flying robots in recent years has prospered. Operating an indoor blimp robot for a long time is difficult because the payload is small, multiple batteries cannot be stacked, and the design of a thruster that gives freedom to the entire blimp robot is difficult. Therefore, an autonomous charge that allows operation for a long time is needed. We have developed a method of landing with orbital control of the charge point that gives autonomy to a blimp robot. The possibility of landing with orbital control is shown. This work was presented in part at the 10th International Symposium on Artificial Life and Robotics, Oita, Japan, February 4–6, 2005 An erratum to this article is available at .     

Effects of water-soluble

The effect of the amount of a water-soluble, lactose, on cephalexin (CEX) release from bioactive bone cement consisting of bisphenol--glycidyl methacrylate (bis-GMA), triethylene-glycol dimethacrylate (TEGDMA) resin and apatite- and wollastonite-containing glass-ceramic (A–W GC) powder was investigated. A–W GC powder containing 5% CEX and lactose powders hardened within 5 min after mixing with bis-GMA/TEGDMA resin, and furthermore its compressive strength was expected to be higher than that of polymethylmethacrylate cement. In vitro CEX release from bioactive bone cement pellets in a simulated body fluid at pH 7.25 and 37°C continued for more than 2 wk. The drug-release rate increased with increasing amount of lactose powder in the mixture. CEX release profiles followed the Higuchi equation in the initial stage, but not in later stages. As hydroxyapatite was precipitated out on the cement surface, the CEX release rate decreased. The micropore distribution of the cements measured by mercury porosimetry also supported the variation in drug release due to cement porosity being mainly a result of the dissolution of lactose in the cements. These results suggest that the rate of CEX release from bioactive bone cement could be controlled by varying the amount of lactose in the cement system. © 1999 Kluwer Academic Publishers     

Observation of residual stress and defects in silicon induced by scribing

Residual stresses induced by three scribing methods, diamond point scriber, laser scriber and diamond blade saw, are studied quantitatively by infra-red photoelasticity. It is clear that diamond blade saw scribing is most desirable, for residual stress induced by it is several times smaller than the stress caused by the other methods. The stress gradient differs between the laser scribed sample and the others, probably because of the difference in stress generation mechanism. Removing the damaged layer by etching reduces residual stress. The three scribing methods are also studied by the observation of defects after annealing and the results are compared with those determined by photoelastic measurement.     

Stabilization of oscillating modes in a LiNdP4O12laser

Suppression of mode competition in a LiNdP4O12(LNP) laser is reported. The stabilization of the oscillating modes was achieved with a quartz quarter-wave plate placed within an optical resonator without any external modulation.