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31.
Poly(2,6-dimethyl-1,4-phenylene ether) (PPE) is an engineering plastic with high heat distortion temperature. Melt processing of neat PPE is usually accompanied with thermal degradation. The degradation problem is solved by blending with polystyrene to reduce the processing temperature. We propose an alternative using triallylisocyanurate (TAIC). TAIC is a low viscosity liquid that can be cured by peroxide, e.g. α,α′-bis(t-butylperoxy-m-isopropyl)benzene (PBP), to provide a thermoset. The PPE/TAIC mixture was shown to have the upper critical solution temperature (UCST) type phase behavior. At the single-phase regime above UCST and below the cure temperature (∼180°C for PBP), the mixture had a low viscosity, less viscous than a conventional thermoplastic such as PC and PP. That is, a nice window for injection molding was available, e.g., at 100°C to 160°C for a 50/50 blend. After injecting into a hot mold set at cure temperature, the blend cured in a short time (∼80% conversion in 5 min). Then the molded and partly cured material kept its shape and dimensions during post-cure in a hot chamber at higher temperature (e.g. 250°C). Using transmission electron microscopy and dynamic mechanical analyses, it was shown that the cured blend had a bicontinuous two-phase structure with periodic spacings of ∼30 nm, suggesting a structure formation via a spinodal decomposition driven by the increase in molecular weight of TAIC during cure. The cured material showed excellent flexural strength and high chemical resistance. 相似文献
32.
Shinji Miwa Norio Yamamoto Katsuhiro Hayashi Akihiko Takeuchi Kentaro Igarashi Hiroyuki Tsuchiya 《International journal of molecular sciences》2022,23(3)
Simple SummaryChondrosarcomas develop chemoresistance to standard anticancer drugs, making it difficult to control unresectable or metastatic chondrosarcomas. To improve the clinical outcomes of chondrosarcoma, new treatment approaches, such as molecule-targeting agents and immunotherapy, are needed. Recent research has revealed promising biomarkers and therapeutic targets for chondrosarcoma. In addition, several molecule-targeting agents have shown favorable antitumor activities in several clinical studies in patients with advanced sarcomas, including chondrosarcoma. This review summarizes recent basic studies on biomarkers and therapeutic targets and recent clinical studies on treating chondrosarcomas.AbstractDue to resistance to standard anticancer agents, it is difficult to control the disease progression in patients with metastatic or unresectable chondrosarcoma. Novel therapeutic approaches, such as molecule-targeting drugs and immunotherapy, are required to improve clinical outcomes in patients with advanced chondrosarcoma. Recent studies have suggested several promising biomarkers and therapeutic targets for chondrosarcoma, including IDH1/2 and COL2A1. Several molecule-targeting agents and immunotherapies have shown favorable antitumor activity in clinical studies in patients with advanced chondrosarcomas. This review summarizes recent basic studies on biomarkers and molecular targets and recent clinical studies on the treatment of chondrosarcomas. 相似文献
33.
Magdalena
miech Pawe Leszczyski Christopher Wardell Piotr Poznaski Mariusz Pierzchaa Hiroaki Taniguchi 《International journal of molecular sciences》2022,23(3)
The accumulation of mutations in cancer driver genes, such as tumor suppressors or proto-oncogenes, affects cellular homeostasis. Disturbances in the mechanism controlling proliferation cause significant augmentation of cell growth and division due to the loss of sensitivity to the regulatory signals. Nowadays, an increasing number of cases of liver cancer are observed worldwide. Data provided by the International Cancer Genome Consortium (ICGC) have indicated many alterations within gene sequences, whose roles in tumor development are not well understood. A comprehensive analysis of liver cancer (virus-associated hepatocellular carcinoma) samples has identified new and rare mutations in B-Raf proto-oncogene (BRAF) in Japanese HCC patients, as well as BRAF V600E mutations in French HCC patients. However, their function in liver cancer has never been investigated. Here, using functional analysis and next generation sequencing, we demonstrate the tumorigenic effect of BRAF V600E on hepatocytes (THLE-2 cell line). Moreover, we identified genes such as BMP6, CXCL11, IL1B, TBX21, RSAD2, MMP10, and SERPIND1, which are possibly regulated by the BRAF V600E-mediated, mitogen-activated protein kinases/extracellular signal-regulated kinases (MAPK/ERK) signaling pathway. Through several functional assays, we demonstrate that BRAF L537M, D594A, and E648G mutations alone are not pathogenic in liver cancer. The investigation of genome mutations and the determination of their impact on cellular processes and functions is crucial to unraveling the molecular mechanisms of liver cancer development. 相似文献
34.
Shin Irumagawa Keiko Hiemori Sayoko Saito Hiroaki Tateno Ryoichi Arai 《International journal of molecular sciences》2022,23(2)
Lectins, carbohydrate-binding proteins, are attractive biomolecules for medical and biotechnological applications. Many lectins have multiple carbohydrate recognition domains (CRDs) and strongly bind to specific glycans through multivalent binding effect. In our previous study, protein nano-building blocks (PN-blocks) were developed to construct self-assembling supramolecular nanostructures by linking two oligomeric proteins. A PN-block, WA20-foldon, constructed by fusing a dimeric four-helix bundle de novo protein WA20 to a trimeric foldon domain of T4 phage fibritin, self-assembled into several types of polyhedral nanoarchitectures in multiples of 6-mer. Another PN-block, the extender PN-block (ePN-block), constructed by tandemly joining two copies of WA20, self-assembled into cyclized and extended chain-type nanostructures. This study developed novel functional protein nano-building blocks (lectin nano-blocks) by fusing WA20 to a dimeric lectin, Agrocybe cylindracea galectin (ACG). The lectin nano-blocks self-assembled into various oligomers in multiples of 2-mer (dimer, tetramer, hexamer, octamer, etc.). The mass fractions of each oligomer were changed by the length of the linkers between WA20 and ACG. The binding avidity of the lectin nano-block oligomers to glycans was significantly increased through multivalent effects compared with that of the original ACG dimer. Lectin nano-blocks with high avidity will be useful for various applications, such as specific cell labeling. 相似文献
35.
Sho Kano Huilong Yang John McGrady Tomonori Ihara Hazuku Tatsuya Hiroaki Abe 《Journal of Nuclear Science and Technology》2019,56(3):300-309
The radiation-induced surface activation (RISA) effect will be applied to the core design in supercritical light water reactor (SCWR) in order to achieve a high performance with excellent economy and safety. The purpose of the present study is to investigate the RISA effect in the candidate fuel cladding materials in SCWR such as PNC1520. The change of weldability due to RISA effect and the related microstructure analysis were performed in oxidized PNC1520 and 304 stainless steel with various oxidization periods. The phases contained in the surface oxide layer of the present specimen were identified as Fe2CrO4, γ-Fe2O3, and Fe2O3. The lifetime of 13.8 days for wettability improving factor was confirmed in the ultraviolet (UV) irradiation. Meanwhile, the long life of 13.8 days and short life of 0.8 days for wettability improving factors were identified in the γ-ray irradiation. Based on the fact that the band gap energies of Fe2CrO4, γ-Fe2O3, and Fe2O3 were, respectively, 2.1, 2.0, and 2.2 eV, and the photo energies of UV and γ-ray irradiation were 4.48 eV and 13.3 MeV, it is therefore clarified that the hydrophilization on the oxide layer is ascribed to the RISA effect. 相似文献
36.
Hiromichi Gima Jun Adachi Masahito Katayama Hiroaki Muta Masayoshi Uno Shinsuke Yamanaka 《Journal of Nuclear Materials》2009,389(1):155-159
We prepared polycrystalline pellets of (U,Y)O2, containing YO1.5 up to 11 mol.%. We performed indentation tests on the pellets, and evaluated the Young’s modulus and hardness. We measured the heat capacity and the thermal diffusivity, and evaluated the thermal conductivity. We succeeded in evaluating the effect of Y content on the thermophysical properties of (U,Y)O2. We revealed that the Young’s modulus, hardness, and thermal conductivity of (U,Y)O2 decreased with increasing the Y content. 相似文献
37.
Xuan Lian Hiroaki Miyoshi Yuki Mitsuya Kenji Shimazoe 《Journal of Nuclear Science and Technology》2018,55(7):805-811
The liquid crystal display (LCD) technology allows several simple circuits to be built using thin film transistors, thus making fabrication of compact, integrated, large-area, and low-cost micro-pattern gaseous detectors possible. In this work, a single-grid-type micro-strip gas chamber (S-MSGC) using transparent electrodes based on the LCD technology was fabricated and successfully operated in several gas mixtures. The detector was coupled with a multi-pixel photon counter to detect an optical signal through the transparent substrate in Ar/CF4 gas. Both electrical and optical signals were measured and the light yield of the detector was acquired. Successful operation of the S-MSGC can be considered the very important first step for development of the next target of integrated devices. 相似文献
38.
Tadashi Inoue Takeo Onchi Hiroaki Kôyama Hiroshige Suzuki 《Journal of Nuclear Materials》1978,74(1):114-122
The paper describes radiation effects on 84C pellets used as control rod elements in the Enrico Fermi Fast Breeder Reactor. Pellet swelling (Δ) caused by irradiation was less than 1% in which crystal lattice swelling was less than 20%. Many microcracks, a main cause of pellet swelling, appeared in the irradiated pellets. The production of microcracks was related to graphite precipitation in the pellets before irradiation. Open pores which did not exist in the unirradiated pellets were formed in the irradiated ones. In a unit cell of B4C, the α-axis elongated by 0.025 Å and the shrank by 0.07 Å by irradiation. Moreover, we found three recovery stages which were from room temperature to 400°C, from 400 to 750°C and from 850 to 1100°C. The recovery mechanisms in the irradiated pellets are discussed in terms of the helium behavior. 相似文献
39.
Reversible crosslinking in cellulose. I. Determination of mercaptan and disulfide in modified cotton
Mercaptan and disulfide contents of modified cotton fabrics could be determined by application of Leach's polarographic method for wool, with minor modification. It was found that mercaptocellulose prepared by the reaction of tosyl cellulose and potassium thiolacetate followed by alkaline hydrolysis contained considerable amounts of disulfided in addition to mercaptain. Iodometric titration of mercaptocellulose gave a higher value of mercaptan than that obtained by the polarographic method. The mercaptan and disulfide contents and methylene blue uptake of the iodine-treated samples indicate that some of the mercaptan groups further undergo oxidation to acidic groups as a result of the iodine treatment. The spatial effect in the oxidation of mercapto groups in modified cotton is briefly discussed. 相似文献
40.
Masaaki Takehisa Sueo Machi Hiromasa Watanabe Takashi Ueno Seiichi Takahashi Ryoji Tsuchiya Kanji Otaguro Isao Motoda Yoshio Takasaka Kazukiyo Miyanaga Waichiro Kawakami Kouichi Yamaguchi Takanobu Sugo Hayato Nakajima Terutaka Watanabe Chuhei Hinachi 《应用聚合物科学杂志》1979,24(3):853-864
Radiation-induced bulk polymerization of ethylene was carried out with use of a pilot plant with a 10 liter reactor at pressures of 225–400 kg/cm2, temperatures of 30–95°C, ethylene feed rates of 5–28 kg/hr, and dose rate of 3.8 × 105 rad/hr. Characteristics of the process are mild polymerization conditions and capability of producing medium density polyethylene in powder form. The spacetime yield and molecular weight of polymer were in the range of 3.5 to 13.1 g/liter hr and 2.2 × 104 to 14 × 104, respectively. The space-time yield increased with mean residence time and 2.4 powders of pressure, and decreased with temperature. Molecular weight changed similarly with the reaction conditions. These results were consistent with those of the bench plant experiment and the scale effect was small. Polymer deposit to the reactor wall limited a period of continuous operation of the plant. The amount of deposited polymer was increased with the square of reaction time. The rate of polymer deposit was proportional to polymer concentration and to the cube of pressure. The polymer deposit cannot be solved in the bulk process. 相似文献