Metal-free phthalocyanine (H2Pc) molecule adsorbed on the Au(111) surface: formation of a wide domain along a single lattice direction

Using low-temperature scanning tunneling microscopy (STM), we observed the bonding configuration of the metal-free phthalocyanine (H₂Pc) molecule adsorbed on the Au(111) surface. A local lattice formation started from a quasi-square lattice aligned to the close-packed directions of the Au(111) surface. Although we expected the lattice alignment to be equally distributed along the three crystallographically equivalent directions, the domain aligned normal to the ridge of the herringbone structure was missing in the STM images. We attribute this effect to the uniaxial contraction of the reconstructed Au(111) surface that can account for the formation of a large lattice domain along a single crystallographical direction.     

Effects of midazolam and propofol on dopamine release from rat striatal slice using a fast-cyclic voltammetry system

In order to evaluate the difference in pharmacological mechanism between midazolam and propofol, we focused on the interaction between dopaminergic and GABAergic neurons in the striatum because of its important role in the regulation of motor system and arousal response, and examined these inhibitory effects on dopamine (DA) release induced by high-K from the rat striatal slice using the fast-cyclic voltammetry method. Between 0.1 and 200 nmol, the standard curve of DA was linear. The peak and the sensitivity of DA oxidation were different from those of norepinephrine and DA main metabolites. The dosages between 0.1 and 10 micro M of propofol significantly blocked the high-K evoked DA release, although the dosage of larger than 50 micro M of propofol potentiated DA release. In case of midazolam, the dosages between 0.1 and 50 micro M markedly suppressed DA release induced by high-K in a dose-dependent manner. The recovery time of DA release after removal of midazolam from incubation medium was longer than that seen in the treatment of propofol. In conclusion, propofol and midazolam inhibited high-K evoked DA release from striatal slice, although these efficacies were dissimilar. Furthermore the pharmacological effects of larger dosage of propofol was different from those obtained by its smaller dosages. These results suggest that the anesthetic actions of propofol and midazolam are partially related to inhibition of DA neuron A1 activity and that the excitatory symptom induced by a larger dose of propofol may be related to its potantiation of DA release.     

Planar TJS lasers fabricated in semi-insulating GaAs substrates for optoelectronic integrated circuits

TJS lasers with a planar structure were fabricted by growing GaAs-AlGaAs double heterstructures in reverse-mesa-etched shapes in semi-insulting GaAs substrates. Continuous single-mode operation was achieved at temperatures up to 110°C. The minimum threshold current was 25 mA at 25°C.     

Prenatal diagnosis and fetal pathology of Tay-Sachs disease

1. The influence of the anorectic drugs fenfluramine, mazindol, mefenorex, phentermine and R 800, an experimental compound, on pulmonary vascular resistance has been studied in the isolated, perfused rat lung. 2. R 800 caused a strong vasoconstriction, which was not antagonized by methysergide of phentolamine; the other drugs listed did not alter vascular resistance. 3. Mazindol and phentermine significantly prolonged the vasoconstrictive effect of serotonin due to inhibition of its metabolic breakdown. 4. Although fenfluramine inhibited serotonin metabolism it also prevented the vasoconstrictive effect of serotonin, due to its ability to act as a serotonin antagonist. 5. Mefenorex did not affect pulmonary vascular resistance, either directly or indirectly via a serotoninergic mechanism.     

Hand-scan OCR with a one-dimensional image sensor

We have developed a hand scanning type OCR, an optical character reader, which is applicable to POS terminals, etc. It uses a one-dimensional image sensor for small size and low cost. We developed a new recognition method which can overcome the irregularity of the hand scanning. Our method has two kinds of counters to extract the horizontal line features. One is a black occurrence counter and the other is a front shape counter. Normalizing these data reduces the influence of pattern variation. The method has been tested widely all over the world as a commercial OCR-A font reader.     

Sliding Dynamics of the Wigner Crystal on Liquid He

The Wigner crystal on liquid He accompanies with periodic corrugation of the He surface; dimples. The dynamics of the crystal is coupled with the motion and the deformation of the dimples. Nonlinear phenomena found in AC Corbino conductivity are attributed to the collective sliding of the electrons out of the dimples. In order to inspect the dynamical transition to the sliding state, we have developed a novel experimental method using a so-called t² pulse, whose leading and trailing edges change in proportion to the square of time; V t². Since the force exerting upon the crystal is proportional to the time derivative of the input voltage, dv/dt, the t²-pulsed method is expected to realize a continuous sweep of the driving force, resulting in the real-time observation of the sliding transition. The observed response shows clearly the sliding, revealing that the external force to the crystal determines the sliding transition.     

Ten-thousand-hour operation of crank transverse-junction-stripe lasers grown by metal-organic chemical vapor deposition

For over 10 000 h, crank transverse-junction-stripe (TJS) laser diodes, grown by metal-organic chemical vapor deposition (MOCVD) maintain low and quite stable operating currents in the automatic-power-control aging with output power of 5 mW/facet at 55°C and 70°C. These MO-CVD lasers have excellent initial characteristics and small distributions of the characteristics. The reason for this excellent result is discussed in relation to the crystalline quality and the uniform growth of MO-CVD wafers.     

Liquid membrane operations in a microfluidic device for selective separation of metal ions

A three-phase flow, water/n-heptane/water, was constructed in a microchannel (100-microm width, 25-microm depth) on a glass microchip (3 cm x 7 cm) and was used as a liquid membrane for separation of metal ions. Surface modification of the microchannel by octadecylsilane groups induced spontaneous phase separation of the three-phase flow in the microfluidic device, which allows control of interfacial contact time and off-chip analysis using conventional analytical apparatus. Prior to the selective transport of a metal ion through the liquid membrane in the microchannel, the forward and backward extraction of yttrium and zinc ions was investigated in a two-phase flow on a microfluidic device using 2-ethylhexyl phosphonic acid mono-2-ethylhexyl ester (commercial name, PC-88A) as an extractant. The extraction conditions (contact time of the two phases, pH, extractant concentration) in the microfluidic device were examined. These investigations demonstrated that the conventional methodology for solvent extraction of metal ions is applicable to solvent extraction in a microchannel. Finally, we employed the three-phase flow in the microchannel as a liquid membrane and observed the selective transport of Y ion through the liquid membrane. In the present study, we succeeded, for the first time, in the selective separation of a targeted metal ion from an aqueous feed solution to a receiving phase within a few seconds by employing a liquid membrane formed in a microfluidic device.     

Purification of Cu by hydrogen plasma-arc zone melting and characterization of trace impurities by secondary ion mass spectrometry

Purification of 4N (99.99%) and 6N (99.9999%) purity Cu rods by hydrogen plasma-arc zone melting was carried out. Weight loss in the 4N and 6N Cu rods as a function of number of zone refined passes revealed a higher rate of impurity removal by vaporization in 4N Cu when compared to 6N Cu. Purification effect was studied by analyzing major impurities like Mg, Si, Ca, Ti, Cr, Ni and Fe by O₂⁺ ions and C, O, As, Cl, P and S by Cs⁺ ion sources using secondary ion mass spectrometry. A remarkable decrease of Si, Ti and Fe impurity concentrations in Cu at x/L = 0.03 after 10 zone passes was observed, but no similar purification effect along the remaining length of the zone refined copper rod was observed. Mg, Se and Ca in the Cu rods were reduced faster by a high evaporation effect due to P_i/P_Cu > 10². On the other hand, removal of O, C, S and Se was expectedly dominated by vaporization in the form of H₂O, CH_4, H₂S, and H₂Se through thermodynamically favored reactions. The overall segregation rate of the individual impurity elements was decreased with an increase in the purity from 4N to 6N of Cu rods. SIMS analysis of trace impurities was successfully carried out on HPZM Cu for quantitative estimation.